Chinese materia medica (CMM), comprising a diverse array of natural substances from plants, animals, and minerals, has been integral to Traditional Chinese Medicine (TCM) throughout history. This study investigates the dynamic evolution of CMM, noting shifts in species for improved therapeutic effects…

A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

Biological cells, the basic building blocks of all life forms, are surrounded by a lipid membrane. More than half of the membrane is occupied by membrane proteins, which can regulate the cell functionality through specific arrangements.

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…

Over het gedrag van mensen valt ontzettend veel te leren en dat ga je tijdens je bacheloropleiding ook volop doen. Je bestudeert de theorie, je leert hoe je psychologisch onderzoek doet en je schrijft een bachelorscriptie.

Overstappen naar bachelor Psychologie aan Universiteit Leiden

Woensdag 11 december 2019 heeft de tweede bijeenkomst van Pre-Study Programme (PSP) plaatsgevonden. Zowel in Leiden als in Den Haag kwamen de teams voor het eerst bij elkaar in subgroepjes.

Promotor: A.P.IJzerman, Co-Promotor: L.H. Heitman

Een goede taalontwikkeling is van belang voor de cognitieve en sociale ontwikkeling, om te kunnen communiceren en om te kunnen leren. Als de taalontwikkeling niet verloopt zoals verwacht, kan dit allerlei consequenties hebben. Kinderen met een extra X of Y chromosoom hebben een verhoogd risico op problemen…

Promotor: M. Ubbink, Co-promotor: G. Siegal

The Copenhagen interpretation of quantum mechanics states that a measurement collapses a wavefunction onto an eigenstate of the corresponding measurement operator.

In this thesis the combinatorial use of bioorthogonal labelling and Electron Microscopy (EM)-based imaging techniques is explored to enable observations of specific molecular targets in their ultrastructural context within the cell.

Lezing, Lezingenreeks vergelijkende Indo-Europese taalwetenschap (VIET)

Hoe beheren humanitaire responsorganisaties (HRO's) en virtuele en technische gemeenschappen (V&TC's) gezamenlijk de processen voor het bepalen van de betekenis van rampen, en welke uitdagingen vormen de effectiviteit van deze samenwerkingen tussen 2010 en 2016?

Een vergelijkende analyse van legitimeringsstrategieën in drie landen: Rusland, Venezuela en de Seychellen.

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

This thesis presents the first synthetic peptides ADP-ribosylated on serine, threonine, tyrosine, arginine and cysteine.

Op 19 september 2019 verdedigde Lynette Janssen zijn proefschrift 'EU Bank Resolution Framework: A comparative study on the relation with national private law'. Het promotieonderzoek is begeleid door promotoren prof.mr. W.A.K. Rank en prof.mr. M. Haentjens.

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

Op 10 juni 2021 verdedigde Merinda Stewart haar proefschrift 'Freedom of Overflight: A Study of Coastal State Jurisdiction in International Airspace'. Het promotieonderzoek is begeleid door promotoren prof.dr. P.M.J. Mendes de Leon en prof.dr. J.J. Rijpma.

Op 26 september promoveert Cosmas Rai Amenorvi. Het Leiden University Centre for Linguistics feliciteert Cosmas!

On the largest scale, the Universe resembles a cosmic spiderweb. Most galaxies coexist in small groups within the threads of this web. At the nodes of the threads are enormous groups of galaxies forming the largest structures in the universe still held together by gravity: clusters of galaxies.

In dit artikel heeft Lianne Visser bijgedragen aan het begrip rondom samenwerkend bestuur als uitdagende aanpak voor hardnekkige problemen.

This thesis focuses on the development of sample-preparation methods for small amounts of samples and applying the developed methods to muscle tissues to investigate the mechanisms involved in sarcopenia.

The demand for neodymium-iron-boron (NdFeB) magnets is rapidly growing, while the neodymium supply chain is under pressure. Recycling can alleviate these issues. This thesis investigates the potential for deploying novel magnet recycling technologies and their environmental consequences.

Promotie

Solar energy harnessed by plants and algae has great potential to be converted into biofuels for future generations.

This thesis investigated miniaturized mass spectrometry (MS)-based analytical methods to address challenges in analyzing biomass-restricted biological samples.

Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi

Centraal in dit proefschrift staan de perspectieven van docenten met betrekking tot zelfstandig leren.

Like a mixture of oil and water, lipid membranes separate into two liquid phases.

Including modelling as part of software development appears to have various benefits.

n this PhD thesis, the recombination of different atomic lattices in stacked 2D materials such as twisted bilayer graphene is studied. Using the different possibilities of Low-Energy Electron Microscopy (LEEM), the domain forming between the two atomic layers with small differences is studied.

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

Promotie

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Promotores: Prof.dr. C.A.M.J.J. van den Hondel, Prof.dr. V. Meyer (Technische Universität Berlin)

In this project of the Center for Public Values & Ethics (CPVE) ongoing research is conducted on the history of advice to Dutch central government by so-called State committees from 1814 to 2014. State committees have been installed by Dutch central government since 1814 to provide expert advice, research…

Neuraminidases are enzymes that cleave glycosidic linkages of sialic acid. These enzymes are involved in influenza infections as well as in many cellular processes in mammals and micro-organisms.

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

Criminologen houden zich bezig met het onderzoek naar wat criminaliteit is, wat de oorzaken en gevolgen ervan zijn, en hoe je criminaliteit het beste kunt bestrijden.

Bij onze rechtenstudie ontwikkel je je tot een veelzijdige jurist. Je werkt aan een academische houding en ontwikkelt juridische vaardigheden. Bekijk meer

This thesis examines enzyme domain architecture and engineering to improve the breakdown of lignocellulose and starch, abundant biopolymers crucial for sustainable biofuel and biochemical production. Carbohydrate-active enzymes (CAZymes) facilitate this degradation, but the structural complexity of…

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

The Datini Institute has launched a call for research papers for its 54th Study Week (14-18 May 2023). Deadline for submission: 10 April 2022.

A framework for prospective/ex-ante life cycle assessment (LCA) and ecological risk assessment (ERA) of emerging technologies is developed and applied to a case study of III-V/silicon photovoltaic panels.

Op 1 december 2020 verdedigde Bernadette Muscat haar proefschrift 'Insolvency Close-out Netting: A comparative study of English, French and US laws in a global perspective'. Het promotieonderzoek is begeleid door promotoren prof.mr.drs. M. Haentjens en prof.mr. B. Wessels.

Dit proefschrift omvat vier deelstudies naar de inhoud en structuur van de opvattingssystemen van natuurkundedocenten over het leren en onderwijzen van natuurkunde in het voortgezet onderwijs (VO) in Nederland.