Op 22 januari kwam een panel van internationale experts op het gebied van nucleaire afschrikking bijeen op de Campus Den Haag om de toekomst van nucleaire afschrikking in Europa te bespreken. Het panel besprak de belangrijke aspecten van nucleaire strategie en de impact van Russische nucleaire retoriek…

Plant exudates appeared long time ago in the history line of life in the early Devonian. They are typical saps produced by specialized cells.

Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.

Thomas Bakkum en Tom van der Wel, promovendi bij het Leids Instituut voor Chemisch Onderzoek, winnen poster awards bij de EMBL Chemical Biology Conference 2018 in Heidelberg.

Wij richten ons op natuurlijke producten van onderzoek, de traditionele geneeskunde, etnobotanie en fytochemie.

Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…

This thesis highlights the significant role of surface geometry and oxidation state in determining CO adsorption behavior on copper surfaces.

De uitgeverij American Chemical Society’s Publication Division (ACS) en de Nederlandse universiteiten, verenigd in de VSNU, hebben een akkoord bereikt om open access publiceren op te nemen als onderdeel van het uitgeverscontract. Vanaf 2017 worden alle nieuwe artikelen die een auteur, verbonden aan…

Promotor: Prof.dr.ir. J.G.E.M. Fraaije, Co-promotor: A. Kros

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.

This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…

Bijna 1,8 miljoen kijkers zaten er zondagavond klaar voor: het RTL Verkiezingsdebat. Voor de eerste keer in dit verkiezingsseizoen kruisten zes lijsttrekkers op televisie de degens. Hoogleraar Journalistiek en retorica-expert Jaap de Jong maakt de balans op: ‘Geen grote grandeur, geen grote misère,…

De laatste jaren zijn er veel spectaculaire archeologische vondsten aangespoeld op de Nederlandse stranden. Zo ook bijna duizend spitsen van been en gewei uit het Mesolithicum (11,000-8000 v. Chr.). Tot nu toe was het niet bekend welke dieren de mesolithische jager-verzamelaars gebruikten om spitsen…

In 2019 brak de Nederlandse hotelmarkt nog alle records. Nu hebben hotels massaal de deuren gesloten vanwege het coronavirus. Als dit maanden gaat duren, komen hotels onverminderd in zwaar weer.

In dit artikel bespreekt Susanne Kamerling welke maatregelen de Europese democratie beschermen tegen Chinese invloed en inmenging.

Francesca Albanese, VN-rapporteur voor de mensenrechten in de bezette Palestijnse gebieden, bezocht op 8 december de rechtenfaculteit van de Universiteit Leiden in het kader van de Internationale Dag van de Rechten van de Mens.

This thesis investigates the relations between metabolism and anatomy through the use of Magnetic Resonance Imaging (MRI).

Onderwijsminister Jet Bussemaker kreeg op de Dag van de Excellentie op 20 juni een exemplaar van ‘Chemistry in Conflict’, een educatief boek over de rol van chemie in oorlogsvoering. Ludo Juurlink, directeur van het Junior Science Lab, overhandigde het boek.

This thesis investigates the evolution and fate of gaseous exoplanets, which are continuously shaped by stellar activity across both short and long timescales.

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

Na 2,5 jaar als minister van Defensie is het tijd voor Kajsa Ollongen om het stokje over te geven. Voor een volle zaal gaf ze dinsdag haar afscheidsspeech bij de Universiteit Leiden in Den Haag met daarin persoonlijke lessen en herinneringen, van slapen op de grond bij de premier tot de oorlog in Oe…

By growing in a soil plants change the biotic and abiotic properties of the soil in which they grow.

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Multicopper oxidase, laccase, can efficiently reduce oxygen to water and are mostly used in the enzymatic biofuel cells.

This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.

This dissertation combines the use of defined microenvironments, high-resolution fluorescence microscopy, and time-resolved analysis, to study intracellular and cellular motility.

This thesis focuses on developing new chemical synthesis strategies to produce native ADP‑ribosylated biomolecules with precise structural control.

Het onzichtbare zichtbaar maken, dat doet hoogleraar Moleculaire Immunologie Sander van Kasteren. In zijn oratie vertelt hij er meer over.

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

Promotor: A.P.IJzerman Co-promotor: A. Bender

Wetenschappers van de Universiteit Leiden hebben een doorbraak bereikt in de bestudering van de erfelijke stofwisselingsziekte van Pompe. Samen met hun Yorkse collega’s ontwierpen zij een molecuul dat zich bindt aan het enzym dat aan de basis staat van het ziekteverloop. De bevindingen zijn gepubliceerd…

The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.

As a contribution to the changing legislation and evolving societal attitudes concerning environmental issues, this project aims to enhance and manipulate the plants’ own natural defense mechanisms against western flower thrips (WFT).

This dissertation was to develop effective graphene-based nanofluidic devices by developing scalable fabrication methods and elucidating proton transport mechanisms.

Promotor: J. Schaye

This thesis focuses on developing wafer-scale two-dimensional (2D) materials by combining synthesis, transfer, characterization, and device integration of graphene, hexagonal boron nitride (h-BN), and BN-doped amorphous carbon.

Promotor: B. van de Water

Our modern society thrives on chemicals, and demand is only growing with novel chemicals being introduced onto the market. However, with increasing demand, so come potentially increasing ecological consequences of these man-made chemicals.

The first steps are made in personalised cancer vaccination strategies, which aim to induce a more specific immune response with fewer side effects. The activation of cytotoxic T cells is crucial for an effective immune response.

Biopolymer sequencing with graphene edge-based tunnel junctions has the potential to overcome current limitations with the third generation of sequencing based on biological nanopores.

Humanity stands at a pivotal juncture, facing the dual challenge of environmental sustainability and rapid population growth, projected to exceed 11 billion by century’s end.

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

Promotor: H.V.J. Linnartz

This thesis focuses on the design and synthesis of activity-based probes and inhibitors targeting enzymes involved in the degradation of specific plant glycans.

This thesis provides an overview of the development of the Pair Configuration to Molecular Activity Coefficient (PAC-MAC) model.

The cellular metabolism of immune cells constitutes an important part of their proper function and activation. Using T cells as an example, this phenomenon is highlighted by the metabolic reprogramming that occurs in these cells upon activation.