Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.

This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.

Promotor: T. Hankemeier, Co-promotor: R.J. Vreeken

Patients share valuable advice and experiences with their peers in online patient discussion groups.

Promotor: A.P.IJzerman Co-promotor: A. Bender

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

Hoewel bacteriën meestal niet met het blote oog te zien zijn, vormen ze de stille kracht achter veel processen in ons dagelijks leven.

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

This dissertation investigates the energy and material related impacts of the transition towards a low-carbon heating system in the Netherlands, in the context of its 2050 climate and circular economy policy goals.

Promotor: G.P. van Wezel, Co-Promotor: E. Vijgenboom

Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…

The thesis is about the study of shell evolution of the Hydrocenidae of the genus Georissa. This thesis started with a general overview on the evolutionary process of animals due to ecological changes.

Dit boek onderzoekt de impact van het VN-Verdrag inzake de Rechten van het Kind (IVRK) op nationale en internationale rechtspraak, sinds de aanname van dit verdrag in 1989. Het boek verschaft inzicht in de functies, uitdagingen en beperkingen van het IVRK in nationale, regionale en internationale juridische…

This thesis presents pioneering work on the panchromatic emission of some of the most luminous galaxies in the early Universe: star forming galaxies and active galactic nuclei.

High-angular-resolution observations of the circumstellar material have uncovered numerous and very diverse substructures in protoplanetary discs, raising the question of whether they are caused by forming planets or other mechanisms.

Promotor: S.J. Edixhoven, L.D.J. Taelman

The Minor Computational Approaches to Disease, Signaling and Drug Targets (CADSDT) is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs.

Promotor: W. Jaffe, Co-promotor: K. Meisenheimer

Promotor: Johan Kuiper, Co-promotor: Saskia C.A. de Jager

Promotor: Prof.dr. M. Ubbink

Hoe zetten belangenorganisaties in Nederland strategisch procederen in om politieke, maatschappelijke of juridische veranderingen te realiseren, en hoe verhoudt deze strategie zich tot andere klassieke vormen van beleidsbeïnvloeding?

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

The haplolepideous mosses (Dicranidae) comprise about 4000 species distributed over a wide range of habitats, with great gametophytic and sporophytic morphological variation. Their monophyly is well supported by the results of several molecular phylogenetic studies, which shed light on their relationships…

Explore "Surgical anatomy of the leg in relation to nerve injuries" at Boerhaave Nascholing. Read more here.

Promotor: P. T. de Zeeuw, Co-promotor: N. Neumayer; G. van de Ven

Trigonostemon Blume is a plant genus in the family Euphorbiaceae comprising 59 species.

Promotor: Prof.dr. W.T.F. den Hollander

All crested and marbled newts (the genus Triturus) suffer from an unusual genetic abnormality, called a balanced lethal system, that kills exactly half of their offspring. How can a trait so disadvantageous have survived millions of years of natural selection?

Subproject of the ERC project 'Challenging the Liberal World Order from Within: The Invisible History of the United Nations and the Global South'.

Elk jaar nodigt het Netherlands Institute of Governance (NIG, de Nederlands-Vlaamse onderzoeksschool voor Bestuurskunde en Politicologie) promovendi van alle universiteiten in Nederland en Vlaanderen uit om hun promotor(en) voor te dragen voor de NIG Supervisor of the Year Award. De reden voor de award…

Dissochaeta Blume (Melastomataceae, tribe Dissochaeteae) is well-known as a scrambling plant genus found in Southeast Asia, where it is an inhabitant of the tropical rainforests or evergreen forests.

Op 11 mei 2016 ontving het Hazelhoff Centre for Financial Law Robert Pickel voor de elfde Hazelhoff Guest Lecture, getiteld ‘The Deadliest Sin of the Financial Crisis’.

Promotor: Prof.dr. W.J.G.M. Peijnenburg

Op 11 november 2021 verdedigde Mariana Gkliati het proefschrift 'Systemic Accountability of the European Border and Coast Guard'. Het promotieonderzoek is begeleid door promotoren prof.dr. P. Rodrigues en prof.dr. L. Besselink (UvA).

Het jaar 2017 was het Leiden Asia Year. Leiden heeft al eeuwenlang banden met en kennis over het continent, en het afgelopen jaar werden daar de spotlights op gezet.

Promotor: Prof.dr. M.T.M. Koper, Co-Promotor: F. Calle-Vallejo

Universiteit Leiden is op 28 september met twee projecten aanwezig bij het Discovery Festival, een nachtfestival dat draait om de kick die je krijgt als je nieuwe dingen ontdekt. Antibiotica Gezocht! laat de festivalgangers meewerken in het tijdelijke laboratorium en iSPEX: ‘Meet fijnstof met je smartphone’…

De Leidse Sterrewacht gaat deelnemen aan de activiteiten van het International Year of Light (IYL). Het jaar 2015 is door de Verenigde Naties uitgeroepen tot het International Year of Light and Light-based Technologies. IYL 2015 zal aan de wereld laten zien hoe belangrijk licht en optische technologie…

Een goede taalontwikkeling is van belang voor de cognitieve en sociale ontwikkeling, om te kunnen communiceren en om te kunnen leren. Als de taalontwikkeling niet verloopt zoals verwacht, kan dit allerlei consequenties hebben. Kinderen met een extra X of Y chromosoom hebben een verhoogd risico op problemen…

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

The increasing resistance of pathogenic bacteria to antibiotics necessitates the discovery of new medicines.

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Dit artikel blikt vijf jaar na dato terug op de lessen van de COVID-19-pandemie. De crisis legde kwetsbaarheden bloot in zorgsystemen, bestuur en sociale samenhang.

Masterclass

Promotores: Prof.dr. M. Franx, Prof.dr. M. Kriek (Univ. of California at Berkeley)

Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.

Over the past years it has been discovered that the population of extra-solar planets is large and diverse.