946 zoekresultaten voor “origins of human mijn” in de Publieke website
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based toxicity assessment: towards quantitative risk prediction in humans
Promotor: Prof.dr. M. Danhof
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Hard power and the European Convention on Human Rights
Op 18 juni 2019 verdedigde Peter Kempees zijn proefschrift 'Hard power and the European Convention on Human Rights'. Het promotieonderzoek is begeleid door promotoren prof. dr. R.A. Lawson en prof. dr. H. Duffy.
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José Joordens op BNR over het gedrag van oudste voorouder Lucy
Archeologe José Joordens reageert in het BNR radioprogramma Wetenschap Vandaag op de ontdekking dat onze oudste voorouders meer in bomen leefden dan gedacht.
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Human Rights Elephants in an Era of Globalisation: Commodification, Crimmigration, and Human Rights in Confinement
Op 21 januari 2020 verdedigde Patrick van Berlo zijn proefschrift 'Human Rights Elephants in an Era of Globalisation: Commodification, Crimmigration, and Human Rights in Confinement'. Het promotieonderzoek is begeleid door promotoren prof.dr. J.P. van der Leun en prof.mr.dr. M.A.H. van der Woude.
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Transformation and sublimation of interstellar ices: insights from laboratory experiments and astronomical observations
Stars and planets form within cold, dense clouds of gas and dust drifting through interstellar space. Although dust makes up only a small fraction of this material, it plays a key role in shaping the chemical evolution of these environments.
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pharmacokinetic models to the prediction of local CNS drug concentrations in human
Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.
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Design of selective inhibitors for human immunoproteasomes
The thesis describes the development, synthesis and biological evaluation of several proteasome inhibitor designs. Mainly, this work focusses on designing proteasome inhibitors that selectively inhibit the immunoproteasome, while leaving the constitutive proteasome mostly, if not completely, untouch…
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Targeting Human Proteasomes: Substrates, Inhibitors and Prodrugs
Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.
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The Encyclopedia of Global Human Migration
The Encyclopedia of Global Human Migration biedt een complete verkenning van de prominente thema's, gebeurtenissen en theoretische onderbouwingen van de verplaatsingen van menselijke bevolkingsgroepen van de prehistorie tot heden.
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Online Course Introduction to Comparative Indo-European Lingistics
Indo-European is the name of the language family to which English belongs, along with many sub-families such as Germanic languages and Romance languages. In this course, you will delve into the structure and origins of these branches, the oldest languages belonging to the language family, linguistic…
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Towards an effective biodiversity conservation and governance in the Pontocaspian region
Freshwater and brackish water ecosystems are arguably the most vulnerable ecosystems on earth, due to concentrated human developments in and around them. The Pontocaspian (PC) region located at the border of Europe and Asia contains a variety of brackish water ecosystems and unique inhabitants, known…
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Transfer of "goods" from plants to humans: Fundamental and applied biochemical investigations on retaining glycosidases
The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.
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Vroege jager-verzamelaars veranderden ver voor de eerste landbouw al de ecosystemen van Europa
Een nieuw onderzoek van de Leidse archeologe Anastasia Nikulina en een internationaal team uit Frankrijk, Denemarken, het Verenigd Koninkrijk en Nederland, weerlegt het idee dat jager-verzamelaars vóór de opkomst van de landbouw een verwaarloosbare impact hadden op hun leefomgeving.
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ecology of lion (Panthera leo Linnaeus 1975) populations and human-lion conflicts in Pendjari Biosphere Reserve, North Benin
Promotores: G.R. de Snoo, B. Sinsin, Co-Promotor: H.H. de Iongh
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Impact of land use changes on the human-elephant conflict
Promotor: G.R. de Snoo, W. Kustiawan, Co-promotor: H.H. de Iongh
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Collaborative Meaning-Making
Humans share meaning through language. Over time, repeated interactions have shaped languages into forms that match our cognitive preferences, making them structured, expressive, easy to learn, and ultimately, meaningful.
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Genetic and cellular origins of histiocytic neoplasms
Promotie
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Catecholamine function, brain state dynamics, and human cognition
Het onderzoek in dit proefschrift kijkt naar de rol van het locus ceuruleus - noradrenalinesysteem in verscheidene aspecten van menselijke cognitie, en de modulatie van de staat van het brein.
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The music of language: exploring grammar, prosody and rhythm perception in zebra finches and budgerigars
Promotor: C.J. ten Cate
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structure solution and crystallographic studies of the Sso10a2 and human C1 inhibitor protein
Promotor: Prof.dr. J.P. Abrahams, Co-Promotor: N.S. Pannu
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North Sea noise in the Anthropocene: an impact study of human-made impulsive sounds on free-ranging cod
Sound is everywhere in the marine environment and hearing is therefore a very important for stimuli for fish. They use sound for orientation and communication, during migration, aggregation and spawning, but also for detection of prey and predators.
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Prediction of brain target site concentrations on the basis of CSF PK: impact of mechanisms of blood-to-brain transport and within brain distribution
Promotor: M. Danhof, Co-promotor: E.C.M. de Lange
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NATO Allies and the Protection of Civilians
In dit artikel bespreken Joachim Koops en Christian Patz de uitgebreide beoordeling van de Duitse gereedheid op het gebied van 'Protection of Civilians' (PoC).
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Studies on the Pathogenesis of Chronic Kidney Disease
In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…
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Inextricable ties between chemical complexity and dynamics of embedded protostellar regions
Promotor: E. F. van Dishoeck, Co-promotor: C. Walsh
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Orion's Dragon and Other Stories
Stellar feedback is a crucial ingredient in the evolution of galaxies.
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The European Court of Human Rights reading between the lines
Lezing
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Wil RoebroeksFaculteit Archeologie
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Neanderthaler at ook planten op de koude steppe
Neanderthalers in koude gebieden consumeerden vermoedelijk veel meer plantaardig voedsel dan tot nu toe is aangenomen. Dat ontdekte archeoloog Robert Power dankzij nieuw tandsteenonderzoek. Promotie op 1 november.
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Ethiopian wolf (Canis simensis Rüppell 1835) in a changing landscape: Human carnivore interactions in Afroalpine ecosystems of Ethiopia
Ethiopian wolves are endangered diurnal Afroalpine rodent hunters. I investigated the interaction between wolves, rodents and human land use in Borena Sayint National Park (BSNP), Abune Yosef and Aboi Gara in Ethiopia.
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Ingrid Leijten spreekt bij Centre for Human Rights Erlangen-Neurenberg
Op 21 juni gaf Ingrid Leijten een lezing bij het Centre for Human Rights van de Friedrich-Alexander Universität Erlangen-Nürnberg (CHREN) in Duitsland. Bij het interdisciplinaire CHREN hoort een Masterprogramma in Human Rights waar studenten uit de hele wereld aan deelnemen.
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Fusing Electrical Stimulation and Wearable Robots with Humans to Restore and Enhance Mobility (Hoofdstuk)
Eduard Fosch-Villaronga, universitair hoofddocent bij eLaw, heeft bijgedragen aan 'Cyber–Physical–Human Systems', een boek waarin de nieuwste ontwikkelingen in interacties tussen cyberfysische systemen en mensen worden onderzocht.
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Intentionality: Balance, Complexity, and Organisation in Artworks by Humans and Apes
Heb je ooit voor een abstract kunstwerk gestaan en gedacht: “Dat had een aap ook kunnen maken!”? Nou, dat heb je mis.
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of COVID-19 on international organisations, humanitarian action, and human rights
Dit onderzoek toont hoe internationale organisaties reageerden op humanitaire en mensenrechtenuitdagingen tijdens de COVID-19-pandemie.
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Overlapping institutions in the UN human rights system: Mutually strengthening or undermining?
In dit artikel onderzoekt Valentina Carraro de relatie tussen overlappende VN-mensenrechteninstellingen, met name de verdragsorganen en de Universal Periodic Review (UPR).
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From Biofabrication to Multi-Organ Platforms: Engineering the Human Heart-Kidney Axis In Vitro
Promotie
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International courts in an era of smartphones and social media – improving human rights accountability?
Wat zijn de effecten van digitalisering op de internationale rechtspraak?
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Child Marriage as a Choice: Rethinking agency in international human rights
Op 18 maart 2020 verdedigde Hoko Horii haar proefschrift 'Child Marriage as a Choice: Rethinking agency in international human rights'. Het promotieonderzoek is begeleid door promotoren prof.dr. A.W. Bedner en prof.dr. G.A. van Klinken (UvA).
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models to uncover genes driving tumorigenesis and therapy resistance in human breast cancer
To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.
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Tracing Players Playing Traces: Non/Human Music in Modern and Contemporary Literature
Muziekinstrumenten zijn meerdere dingen: het zijn objecten, maar ook communicatiemiddelen; ze zijn technologisch en ook diep verbonden met belichaming via de speler; en ze laten bepaalde culturele sporen na (Ricoeur 1975/1984). Dit onderzoeksproject onderzoekt hoe literaire teksten van de 19e eeuw tot…
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Anastasia NikulinaFaculteit Archeologie
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Development of a Kidney-on-a-Chip Model for Compound Screening and Transport Studies
Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…
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Interaction with sound for participatory systems and data sonification
This thesis deals with the use of sound in interactions in the context of participatory systems and data sonification. We investigate an interactive environment where participants perceive information of the data through sound elements.
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Modulation of leukocyte homeostasis in atherosclerosis
Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel
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Humans of Honours: Marleen Fleers
In 'Humans of Honours' staat telkens een medewerker, student of alumnus van de Honours Academy centraal. Deze keer: Marleen Fleers (24), student-assistent internationalisering.
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Automated de novo metabolite identification with mass spectrometry and cheminformatics
Promotor: T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier
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Exploring chemical space in covalent and competitive glycosidase inhibitor design
Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency
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Fluorescence Polarization Activity-Based Protein Profiling on Retaining Glycosidases
Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.
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Unravelling the Developmental Origins of Disease: The Power of Mesenchymal Stromal Cells and Monochorionic Twins
Promotie