In dit interdisciplinaire onderzoeksprogramma werken onderzoekers uit vijf verschillende disciplines met elkaar samen. Zij stellen zich hieronder (in het Engels) aan u voor.

Het Brain and Education Lab-team verzorgt verschillende vakken in het veld van Mind, Brain, and Education.

Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

This thesis consists of two main parts. The first part (Chapters 2 and 3) deals with a class of Markov process called Quasi-Skipfree (QSF) processes.

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

Promotor: A.P. IJzerman

This thesis takes steps toward understanding the interaction between gas-phase and solid-state molecules in star- and planet-forming regions.

De traditionele indeling van hersengebieden volstaat niet. Dat ontdekten promovenda Fatemeh (Simeen) Tabassi Mofrad en professor Niels Schiller in testen met proefpersonen die van taal wisselden. Hun onderzoeksresultaten werden gepubliceerd in het wetenschappelijke tijdschrift NeuroImage.

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

Hoe leren we taal? Er valt veel te leren van zangvogels, zo is gebleken. Maar nog nooit zijn baby’s en zangvogels direct met elkaar vergeleken terwijl ze een niet-bestaande taal leren. Taalkundige Claartje Levelt, bioloog Carel ten Cate en informaticus Jelle Zuidema gaan het uitvoeren.

Over the past two centuries, socioeconomic development has improved material living standards but has also intensified environmental pressures, including climate change and biodiversity loss.

This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.

This thesis comprises the development of reproducible synthesis procedures for two-dimensional materials (composed of boron, nitrogen and carbon) on different metallic surfaces.

Waarom is er zoveel informatie over ‘puberende hersenen’ voor ouders en leerkrachten, maar zo weinig voor jongeren zelf?

De Leiden Institute for Brain and Cognition (LIBC) Publieksdag, met als thema 'geheugensporen', trok ruim 700 bezoekers.

Stellar feedback is a crucial ingredient in the evolution of galaxies.

Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.

Dit artikel biedt een systematisch literatuuronderzoek van de belangrijkste principes, normen en strategieën van Security by Design en Privacy by Design.

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri

It is a common technique in global optimization with expensive black-box functions to learn a surrogate-model of the response function from past evaluations and use it to decide on the location of future evaluations.

Promotor: W. T. F. den Hollander, F. H. J. Redig

Constraint multi-objective optimization with a limited budget for function evaluations is challenging. This thesis tackles this problem by proposing new optimization algorithms. These algorithms are applied on holistic ship design problems. This helps naval architects balance objectives like cost, efficiency,…

A common method to solve expensive function evaluation problem is using Bayesian Global Optimization, instead of Evolutionary Algorithms.

Promotor: J. A. Bouwstra

Het Leiden Institute for Brain and Cognition (LIBC) neemt op 29 september de vernieuwde MRI-scanner in gebruik. Het apparaat is sneller en beter dan de huidige opstelling.

Hoe worden nachtruimtes verbeeld, geproduceerd, ervaren en verteld door migrantengemeenschappen in Europa? Dit onderzoeksproject onderzoekt deze vraag in acht Europese steden: Aarhus, Amsterdam, Berlijn, Cork, Galway, Lissabon, Londen en Rotterdam.

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.

The majority (80%) of e-waste generated globally are recycled informally in developing countries.

Positieve herinneringen ophalen kan helpen om je beter te voelen over jezelf. Daarmee wil Charlotte van Schie mensen met een borderline persoonlijkheidsstoornis sterker maken. Ze publiceert over haar onderzoek in Human Brain Mapping en geeft op de LIBC-publieksdag 11 oktober de flashtalk: 'Gekleurde…

Het Brain and Education Lab is gevestigd in de Faculteit der Sociale Wetenschappen van de Universiteit Leiden.

In 2009-2010 ontstond in het westerse discours het idee van een meer ‘assertief’ China, een opvatting die China krachtig van de hand wijst. Niettemin is, vooral sinds Xi Jinping in 2012 aan de macht kwam, duidelijk dat China zijn lang gehanteerde buitenlandse beleidsdoctrine van ‘een lage profilering…

In this work we describe three methods to improve the performance of Quantum Field Theory calculations.

Microglia support the central and peripheral nervous system by forming the first line of defense against hazardous events. Microglia are increasingly acknowledged as critical players in neurodegenerative diseases, highlighting them as potential therapeutic targets.

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

Although plant domestication has significantly altered crop genetics and phenotypes, its effects on the taxonomic and functional diversity of plant-associated microbiomes are not well understood.

OB associations are loose groups of young, massive stars. They constitute the last stage of the massive starformation process, and the context in which new stars are formed.

Congres/symposium

I have Aspergers and that means I’m sometimes a bit different from the norm. And – given the right circumstances – being different is a superpower’, zo twitterde de jonge klimaat-activiste Greta Thunberg. Zij is het voorbeeld van de dynamiek die autisme historisch laat zien. Een beter begrip hiervan…

Samen met wetenschappers van over de hele wereld streeft de ENIGMA-Anxiety Werkgroep ernaar om meer inzicht te krijgen in de neurobiologische karakteristieken van angststoornissen.

The experiments described in this thesis employ local lentiviral knockdowns in brain areas of female zebra finches followed by behavioural assays consisting of preference and Go/Nogo tasks.

This thesis focuses on enhancing predictions of central nervous system drug exposure using the LeiCNS-PK3.0, a physiologically based pharmacokinetic model.

Onder vindt u de wetenschappelijke publicaties van het Navigatie Lab Leiden

Promotor: S.M. Verduyn Lunel, Co-Promotores: S.C.Hille, O.W. van Gaans

Why do sexual violence policies still fail to systematically address men and masculinities, when the need for cultural change among men has been central in public debates since #MeToo?

The dissertation offers new tools and insights to computation and modelling of topological phases, with an emphasis on the aperiodic setting.

Material circularity and energy efficiency are highly relevant and intertwined issues for the transition towards a carbon-neutral and circular built environment. In the Netherlands, the building sector has been rendered a priority towards a circular and low-carbon society.