633 zoekresultaten voor “er al treatment” in de Publieke website
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Symposium en receptie ter ere van afscheid Rikki Holtmaat
Formele gelijkheid vormt sinds lange tijd het hart van EU en internationaal non-discriminatierecht. Daarnaast is materiële gelijkheid door de jaren heen een wettelijke norm geworden, onder meer door middel van de ontwikkeling van de concepten van indirecte discriminatie en doeltreffende aanpassingen…
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Towards the Prevention of Cancer Treatment Related Hearing Loss
Promotie
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Diagnosis, prevention, and treatment of acute respiratory viral infections
Promotie
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Insights into gastric cancer: towards tailored surveillance and treatment strategies
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On preoperative systemic treatment of muscle-invasive bladder cancer
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Novel pharmacometric techniques to quantify the pharmacodynamics of analgesics
The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.
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Chemical tools to monitor and control proteasome activities
Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea
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Regulation of actomyosin contraction as a driving force of invasive lobular breast cancer
In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).
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From data to models: reducing uncertainty in benefit risk assessment: application to chronic iron overload in children
Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua
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Systems pharmacology of the endocannabinoid system
In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).
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Macrophages inhibit human osteosarcoma cell growth after activation with the bacterial cell wall derivative liposomal muramyl tripeptide in combination
CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…
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Structural characterization of bacterial proteins involved in antibiotic resistance and peptidoglycan biosynthesis
This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.
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Development of kinase inhibitors and activity-based probes
Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt
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Tolerant migrant cities? The case of Holland 1600-1900
This pioneering project will answer this question by examining migrants through the eyes of the courts between 1600 and 1900. It aims to reveal patterns of continuity and change in: 1. Treatment of migrants by criminal courts; 2. Violence and conflicts between migrants and native born.
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EU JudgeCo Platform
The ultimate aim of this project is to improve cooperation between courts in different Member States.
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Development of novel anti-cancer strategies utilizing the zebrafish xenograft model
In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…
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KibA Testen App
Kinderen met een specifieke fobie zijn overmatig bang voor bepaalde voorwerpen, dieren of situaties. Specifieke fobieën komen regelmatig voor in de kindertijd en kunnen het leven thuis, op school en daarbuiten best moeilijk maken. Samen met een groot internationaal team hebben we het KibA-programma…
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Ubar Kampung
The Sundanese people, the largest ethnic group in West Java, have been using traditional medicine for a long time. Known as ubar kampung, Sundanese indigenous knowledge, beliefs and practices of traditional medicine are based on local people’s knowledge and use of Medicinal, Aromatic, and Cosmetic (MAC)…
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The aging B cell landscape in atherosclerosis
In this thesis, single-cell approaches were applied to characterize the impact of aging on the immunological B cell landscape in different models of atherosclerotic cardiovascular disease, with the goal to identify and study new B cell-associated biomarkers and therapeutic targets to halt atherosclerosis…
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Mutation-Driven Modulation of GPCR Pharmacology: Insights from Adenosine and Serotonin Receptors
This thesis seeks to investigate how cancer-associated mutations affect the pharmacological properties of selected GPCRs—primarily A2AAR and 5-HT2CR—through a combination of ligand binding assays, signaling readouts, kinetic profiling, and cellular functional assays.
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Stap 2: verkennen
Wat is er al bekend?
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TRIXY Expertisecentrum
TRIXY is een nationaal expertisecentrum, waar clinici en wetenschappers samen werken in de zorg voor kinderen met X en Y chromosoom trisomieën (47,XXY, 47,XXX en 47,XYY). TRIXY is een samenwerking tussen de Universiteit Leiden en het Leids Universitair Behandel- en Expertise Centrum (LUBEC). Lees meer…
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Waarom Universiteit Leiden?
De masteropleiding Farmacie wordt aangeboden door de Universiteit Leiden en gegeven in het Leids Universitair Medisch Centrum.
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Opioid and cannabis utility, effects and side effects in the treatment of chronic pain
Promotie
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Automated tactile stimulation to improve the treatment of Apnea of Prematurity
Promotie