527 zoekresultaten voor “experience safety” in de Publieke website
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The ins and outs of ligand binding to CCR2
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman
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Reverse engineering of drug induced QT(c) interval prolongation: Towards a systems pharmacology approach
Promotor: M. Danhof Co-promotor: O.E. Della Pasqua
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Getting personal: Advancing personalized oncology through computational analysis of membrane proteins
Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.
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The good? The bad? The mutant! Characterization of cancer-related somatic mutations and identification of a selectivity hotspot in adenosine
G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.
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Dynamics and regulation of the oxidative stress response upon chemical exposure
The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…
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Advanced in vitro models for studying drug induced toxicity
Promotor: B.van de Water, Co-promotor: L.S.Price
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Unraveling multifaceted roles of Grainyhead-like transcription factor-2 in breast cancer
Breast cancer is the most common cancer in women worldwide. Metastasis, the process by which cancer cells spread to other parts of the body, makes treatments less effective. It is important to unravel the mechanism of metastasis.
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Non-target effects of GM potato: an eco-metabolomics approach
Promotores: P.G.L. Klinkhamer, P.M. Brakefield, Co-Promotor: M. Bruinsma
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Acquired resistance in pancreatic cancer: characterization and exploration of actionable targets of a multifactorial disease
Pancreatic ductal adenocarcinoma (PDAC) is among the cancers with the highest mortality rate, despite a relatively low incidence.
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Lipid nanoparticle technology for mRNA delivery: Bridging vaccine applications with fundamental insights into nano-bio interactions
Lipid nanoparticles (LNPs) have enabled the success of mRNA vaccines but remain limited in broader therapeutic use by challenges in delivery efficiency, targeting, and mechanistic understanding.
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Blueprints of Disease: Precision Platforms for Modelling Breast Cancer
Breast cancer (BC) is a clinically and biologically heterogeneous disease.
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Filosofie en religie
Het collegeaanbod op het gebied van de filosofie, levensbeschouwing en religie.
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Voorlichtingsactiviteiten
Ontdek de voorlichtingsactiviteiten rond de MSc Nederlandse Politiek aan Universiteit Leiden: master open dagen, webinars, virtuele rondleidingen en Q&A-sessies.
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Nederlandkunde/Dutch Studies (BA)
Is jouw moedertaal een andere dan het Nederlands, ben je geïnteresseerd in het leren van de Nederlandse taal, cultuur en geschiedenis – én vind je het leuk om te studeren in een internationale omgeving? Dan is de Engelstalige opleiding Dutch Studies aan de Universiteit Leiden een bijzondere kans. In…
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English Language and Culture (BA)
Hou je van de Engelse taal, literatuur en cultuur? Droom je ervan om vloeiend Engels te spreken en de verhalen, geschiedenis en invloeden achter deze wereldtaal echt te begrijpen? Dan is de Engelstalige bacheloropleiding English Language and Culture aan de Universiteit Leiden een perfecte keuze voor…
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Schrijf je in voor de Experience Day | Master Population Health Management
Studievoorlichting, Experience Day
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Lived Experience Matters: On the Healing Power of Peer Support and Mental Health Experiences of Professionals
Promotie
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Iber Kasehatan in Sukamiskin: Utilisation of the Plural Health Information and Communication System in the Sunda Region of West Java, Indonesia
This study has been carried out in the community of Sukamiskin, a kelurahan (‘village’) in Bandung, the Capital of West Java Province, located in the Sunda Region of Indonesia.
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Introduction to Network Theory Using Gephi
Workshop
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Geschiedenis
Het collegeaanbod op het gebied van archeologie en geschiedenis.
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Beschrijvende taalkunde
Het documenteren en beschrijven van de talen van de wereld.
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Human Evolution
This multidisciplinary minor provides students with knowledge on how and why humans became the way they are. The minor focuses on the evolution of the species Homo sapiens from other hominin lineages and animal ancestors, and on the various factors shaping this process. Not only is human evolution of…
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Voorlichtingsactiviteiten
Lees meer over informatieve activiteiten voor de MSc International Politics aan Universiteit Leiden, zoals webinars, online Q&A-sessies en evenementen voor toekomstige studenten.
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Exploring big data approaches in the context of early stage clinical
Als gevolg van de grote technologische vooruitgang in de gezondheidszorg worden in toenemende mate gegevens verzameld tijdens de uitvoering van klinische onderzoeken.
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Het tegengaan van online gewelddadige extremistische inhoud: een multidisciplinaire benadering
Dit project verkent innovatieve strategieën om online extremistische inhoud tegen te gaan, met de nadruk op het integreren van traditionele tactieken voor inhoudsmoderatie met gerichte online interventies. Door middel van onderzoek, workshops en data-gedreven experimenten streven we ernaar de volgende…
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Cancer chess: molecular insights into PARP inhibitor resistance
The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…
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Allosteric modulation by sodium ions and amilorides of G protein-coupled receptors
Promotor: A.P. IJzerman
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To explore the drug space smarter: Artificial intelligence in drug design for G protein-coupled receptors
Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…
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Time is of the essence: investigating kinetic interactions between drug, endogenous neuropeptides and receptor
Promotor: A.P. IJzerman Co-promotor: L.H. Heitman
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Quality-driven multi-objective optimization of software architecture design: method, tool, and application
Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M.R.V. Chaudron, Co-Promotor: M.T.M. Emmerich
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Clavis Aurea? Structure-enabled approaches of identifying and optimizing GPCR ligands
Promotores: A.P. IJzerman, H.W.T. van Vlijmen
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Extracellular Matrix Mechanics in the Regulation of the early steps of the Metastatic Cascade
Metastasis is responsible for over 90% of cancer-related deaths and arises from the ability of a small subset of tumor cells to detach from the primary tumor, overcome multiple biochemical and mechanical barriers, disseminate through the body, and colonize distant organs.
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Allosteric modulation and ligand binding kinetics at the Kv11.1 channel
Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman
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Docenten
Prof.dr. Bibi van den Berg is aangesloten bij de leergang Cybersecurity. Zij is hoogleraar Cybersecurity Governance en hoofd van de onderzoeksgroep Cybersecurity Governance.
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Onderwijs
Het Institute of Security and Global Affairs (ISGA) biedt onderwijsprogramma’s aan op bachelor- en masterniveau. Tevens zijn er minoren, wordt er online onderwijs aangeboden en is er onderwijs voor professionals.
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Tessa Hagens -
Britt Duijndam -
Mick van Schaick -
Xiaobing Zhang -
Marije Niemeijer -
Tamara Danilyuk -
Lukas Wijaya -
Linglu Xu -
Serkan Aslan -
Lucy Sinke -
Natasha Tahir -
Kirsten Veltman -
Chantal Pont -
Linda van den Berk -
James Stevens