Promotor: H.J.A. Röttgering, Co-promotor: M. Haverkorn

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

Deelproject van

The NWO-funded research project ‘The Multilingual Dynamics of the Literary Culture of Medieval Flanders, c. 1200- c. 1500’ is hosting a series of e-workshops on the topic of ‘Multilingual Literary Cultures in the Middle Ages’. The program is now available online.

In this Yearbook you will find some fascinating examples of what was done in 2021, not only by ourselves, but also by our international colleagues.

Hifadhi ya Dijiti ya Ustadh Mau

uman skin equivalents (HSEs) are in vitro 3D-skin models that mimic many aspects of the native human skin (NHS) and can be a valuable tool.

Fokelien Kootstra verdedigde haar proefschrift op 23 april 2019

Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua

The global agri-food system plays a critical role in food security and environmental issues.

This multidisciplinary minor provides students with knowledge on how and why humans became the way they are. The minor focuses on the evolution of the species Homo sapiens from other hominin lineages and animal ancestors, and on the various factors shaping this process. Not only is human evolution of…

Jessica Barr and Barbara Zimbalist invite essays that examine any aspect of race and religion in medieval culture and society for a special issue on race and religion in the Middle Ages. Deadline for submission: 1 February 2021.

Death in all types of melanomas is generally caused by metastasis. Uveal melanoma (UM) is the most common intraocular melanoma, there are currently no (patient-derived) animal models that faithfully recapitulate metastatic dissemination of UM.

From the 1920s on, popular music in Southeast Asia was a mass-audience phenomenon that drew new connections between indigenous musical styles and contemporary genres from elsewhere to create new, hybrid forms. This book presents a cultural history of modern Southeast Asia from the vantage point of popular…

With an emphasis on developing novel miktoarm star polymers termed PeptoMiktoStars, this thesis leverages asymmetric polymeric polypept(o)ide frameworks to advance their effectiveness in delivering hydrophobic drugs and nucleic acids.

De onstuitbare opmars van de N.V. Zuid-Korea

Actinobacteria are well known for the production of bioactive natural products, many of which have applications in the fields of human, animal and plant health. Subject of this thesis are the anthracyclines, glycosylated aromatic polyketides with potent anticancer activity.

Humans can see the world through the eyes of other humans and imagine what they know, want, and intend. This competence is known as Theory of Mind.

This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.

Stars and planets form within cold, dense clouds of gas and dust drifting through interstellar space. Although dust makes up only a small fraction of this material, it plays a key role in shaping the chemical evolution of these environments.

Onder welke omstandigheden beperken paramilitaire groepen hun gebruik van politiek geweld? Dit artikel onderzoekt het gebruik hiervan door de PIRA.

Dit artikel gaat in op de onderzoekskloof door te onderzoeken hoe deze instanties hun personeel zo kunnen inzetten dat ze maximale prestaties leveren met het personeel dat ze hebben.

Of all the mass in our Universe, 80% is thought to consist of a hypothetical and invisible substance called dark matter (DM).

The aim of this thesis was to study phage infection in Streptomyces, focused on cell wall-deficient cells. Bacteriophages (or phages in short) attach to the cell wall of bacteria after which they replicate and lyse the host cell.

Dit artikel levert een bijdrage aan een groeiend aantal onderzoeken naar radicalisering. Het richt zich specifiek op het onderscheid tussen individuen die radicalisering en daardoor betrokken raken bij terroristisch geweld en individuen die radicaliseren maar niet betrokken raken bij geweld.

The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.

Streptomyces are filamentous bacteria that produce more than two-thirds of known antibiotics.

De auteurs onderzoeken de afhandeling van cybermisdaadzaken door rechtshandhavers.

Self-assembly offers a promising route to create complex structures and materials using simple building blocks. Through, colloidal self-assembly, we can understand the governing principles of the self-assembly process and unlock its potential in diverse applications in materials science, photonics and…

Om de klimaatcrisis het hoofd te bieden, kan een bepaalde nederigheid van de mens ten aanzien van de natuur van groot belang zijn. Tegelijkertijd kan nederigheid ook politieke overheersing in de hand werken. Hoe kunnen mensen zich op een bescheidener manier tot de natuur verhouden zonder hun vrijheid…

The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

The origin and evolution of galaxies are closely linked to many different physical phenomena.

In this thesis, we present new laboratory data of interstellar dust analogues.

Jan van den Berg heeft zij proefschrift op 8 november 2018 verdedigd.

Ramesh Ganohariti onderzoekt de juridische identiteit in drie post-Sovjet aspirant-lidstaten en schetst in dit artikel vier veelvoorkomende scenario's.

In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

The increasing resistance of pathogenic bacteria to antibiotics necessitates the discovery of new medicines.

Freshwater is an important resource, but at a great risk of species decline due to habitat loss, pollution and over-exploitation, and invasive alien species.

In deze publicatie worden problemen met betrekking tot de grensoverschrijdende afwikkeling van financiële instellingen onderzocht.

By growing in a soil plants change the biotic and abiotic properties of the soil in which they grow.

Op 2 juli promoveert Jiaqi Wang. Het Leiden University Centre for Linguistics feliciteert Jiaqi!

The thesis describes experimental steps towards reduction of friction on the macroscopic scale by scenarios of thermo- and superlubricity well-known on the nanoscale.

Innovation plays an essential role in firms' competitiveness and long-term success. It varies from different types, ranging from run-of-the-mill innovation that brings incremental changes to existing technologies to radical innovation that breaks from existing trajectories.

Nowadays, it is well known that hydrogen and helium (and small traces of lithium and beryllium) were created shortly after the Big Bang, while the heavier elements are created in the cores of stars at different evolutionary stages. When these stars explode as supernovae, they expel metals synthesised…

This thesis investigates the application of deep learning techniques in image analysis across various domains, focusing on four main themes: feature extraction, classification, segmentation, and integration, demonstrating the transformative potential of these technologies.

Promotor: Prof.dr. J.W.M. Frenken

This study seeks to analyse how job stress could be the result of performing administrative tasks

Religion and ethnicity are inextricably linked in discourse within and about Central Asia. One common narrative suggests that as a result of differences between historically sedentary and nomadic populations, ethnic Tajiks and Uzbeks are naturally more religious and more likely to radicalise than their…

This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.