Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

Workshop

Workshop

Promotor: S.M. Verduyn Lunel, Co-promotor: O.W. van Gaans

We have examined sequences from the ligand-binding domain of the nicotinic acetyl choline receptor (nAChR) in 148 vertebrate species. We are in interested in this receptor because the α-neurotoxins of many venomous snakes binds to this receptor in its location at the neuromuscular junction in all ve…

Galaxies form and live inside dark matter haloes. As a consequence, they are exposed to the tidal fields generated by the surrounding matter distribution: this imprints a preferential direction to the galaxy shapes, which leads to a coherent alignment on physically close galaxies, called intrinsic a…

With an emphasis on developing novel miktoarm star polymers termed PeptoMiktoStars, this thesis leverages asymmetric polymeric polypept(o)ide frameworks to advance their effectiveness in delivering hydrophobic drugs and nucleic acids.

The main research question of this thesis was: Can nitrogen cycling on dairy farms on peat soil in the Dutch Green Heart area be improved by adapting management to the nitrogen supply from soil and by using other grassland species and crops without affecting milk production?

Dit boek neemt je stapsgewijs mee in het schrijven van een scriptie, met (voornamelijk) een focus op experimenteel onderzoek, dat het meest veel voorkomt. Door de stappen van experimenteel onderzoek in chronologische volgorde op te splitsen en bij elke stap tips te geven, hopen de auteurs enig houvast…

Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea

The subject of this thesis, ‘Approach to Markov Operators on Spaces of Measures by Means of Equicontinuity’, combines an analytical and probabilistic approach to Markov operators.

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Indigenous Latin American artifacts have attracted the interest of Europeans since the earliest moment of contact between Europeans and the Indigenous peoples of the Americas. The ERC-funded BECACO project uses an innovative multidisciplinary framework to investigate the provenance of ethnographic and…

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

Hybrid Symposium: Medieval miniatures from Byvanck to the RKD. 18 March 2025, Den Haag.

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors.

Promotor: Ronald Cramer, Co-promotor: Serge Fehr

Hydrocarbonylation of alkenes with carboxylic acids in synthesis of carboxylic acid anhydrides is relatively less explored. We herein present a study and optimization of a palladium-catalyzed hydrocarbonylation reaction of alkenes using carboxylic acids as the nucleophile, by which acid anhydrides can…

The marine shipping industry is one of the strongest emitters of nitrogen oxides (NOx), a pollutant detrimental to ecology and human health. Over the last 20 years, the pollution produced by power plants, the industry sector, and cars has been decreasing.

Promotores: Prof.dr. M. Franx, Prof.dr. P.G. van Dokkum (Yale University)

Consequences for sediment stability and seston trapping

Op 11 november 2021 verdedigde Evelien Campfens het proefschrift 'Cross-border Claims to Cultural Objects'. Het promotieonderzoek is begeleid door prof.dr. N.J. Schrijver en prof.dr. W.J. Veraart (VU Amsterdam).

Almost three years after receiving her honorary doctorate, Dr Graça Machel returned to Leiden University. Over the course of two days she spoke with students, researchers, and other interested persons, about human rights – particularly those of women and children – in a world in which these are continually…

The class-imbalance problem is a challenging classification task and is frequently encountered in real-world applications. Various techniques have been developed to improve the imbalanced classification performance theoretically and practically.

Carbon dioxide capture and utilization technologies are necessary to create a truly circular economy. The electrochemical reduction of carbon dioxide to formate is an appealing carbon utilization method as it can be performed at room temperature and pressure, it only requires two electrons, and it has…

Promotores: E. van Dijk, G.R. de Snoo. Co-promotor: H. Staats

Promotores: Prof.dr. M. Franx, Prof.dr. M. Kriek (Univ. of California at Berkeley)

In this thesis, we study different curved single crystals because of the diversity of surface structures across their curvature.

One of the key discoveries in exoplanet research over the past decade is the abundance of small planets in our Milky Way. Despite their high numbers, our understanding of their atmospheres remains limited, and it is unknown if they possess atmospheres at all.

Sorghum (Sorghum bicolor) is a major cereal crop that millions of subsistence farmers in Sub-Saharan Africa (SSA) rely on. However, the scourging impact of the root parasitic weed Striga (Striga hermonthica, a.k.a. “witch-weed”) has remained a major constraint hampering the productivity of sorghum in…

Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…

In our research protein translocation from Agrobacterium into yeast and plant cells is studied to obtain fundamental insights in the translocation process

Wat doe je als je iets te weten wilt komen? Tegenwoordig gebruikt men voornamelijk het internet om informatie te verkrijgen. Een lezer moet deze informatie vaak uit meerdere bronnen halen en die bronnen met elkaar in verband brengen, om zo een compleet plaatje te vormen van het onderwerp. Soms is de…

Despite being the second largest transmembrane protein family after GPCRs, the SLC superfamily has only gained significant attention in early drug development over the past decade.

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

Errors are everywhere, and mechanical failures are especially common: buckled grain silos and cracked support columns are, justly, seen as an issue to be avoided.

To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.

Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

We kunnen ons de conceptuele discussie tussen beide begrippen wel voorstellen. Soms komt bij het horen van deze termen een Hollywood beeld naar voren, soms actualiteit of wetenschappelijk onderzoek. Beide fenomenen worden veelal onderscheiden door hun verschil in doel van de organisatie, modus operandi…

Er verandert wat in de plannen voor de ontwikkeling van de Humanities Campus. De Universiteit Leiden moet kosten besparen vanwege de financiële uitdagingen bij de Faculteit Geesteswetenschappen en de bezuinigingen in het hoger onderwijs. Dit betekent onder meer dat het Lipsius-gebouw na de sloop in…

In this research I assess the impact of the recently discovered gas reserves south off Cyprus on the escalation of the Cyprus conflict.

Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

Ontwerpbureau Inbo en JHK Architecten hebben hun definitieve structuurontwerp voor de nieuwe bèta-campus van de Universiteit Leiden gepresenteerd. In samenwerking met een aantal andere adviseurs wordt vanaf september gestart met het voorlopig ontwerp van de eerste bouwfase.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver