De publieksdag van het Leiden Institute of Brain and Cognition (LIBC) is de afgelopen jaren uitgegroeid tot een van de meest geliefde populairwetenschappelijke evenementen van Leiden. Ook voor de aankomende publieksdag op vrijdag 11 oktober in de Leidse Stadsgehoorzaal lopen de aanmeldingen weer als…

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

Hoe leren we taal? Er valt veel te leren van zangvogels, zo is gebleken. Maar nog nooit zijn baby’s en zangvogels direct met elkaar vergeleken terwijl ze een niet-bestaande taal leren. Taalkundige Claartje Levelt, bioloog Carel ten Cate en informaticus Jelle Zuidema gaan het uitvoeren.

Promotor: A.W. van der Vaart

Promotor: Prof.dr. G.P. van Wezel

Vinasse is a major by-product generated by the sugarcane biofuel industry. It is a source of microbes, nutrients and organic matter and often it is recycled as fertilizer.

Cardiovascular syndromes are the major cause of death in Western societies.

Heart failure is a major health care problem with high mortality.

Promotor: J.A. van Veen, Co-promotor: E.E. Kuramae

Promotor: Prof.dr. J. den Hertog

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals.

Promotor: S.M. Verduyn Lunel, Co-promotor: O. van Gaans

Promotor: Prof.dr. T. Schmidt

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

Optimization tasks in practice have multifaceted challenges as they are often black box, subject to multiple equality and inequality constraints and expensive to evaluate.

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

Enzymes are innately sensitive to changes in the amino acid sequence, which largely constrains their evolutionary potential, i.e., evolvability. This evolutionary burden can be alleviated in the presence of stabilizing mutations, which increase the buffering capacity of enzymes to tolerate mutations…

This thesis discusses several questions regarding the double ramification cycle as a Chow class on the moduli space of stable n-pointed genus g curves using tools from so-called logarithmic geometry.

Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.

Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…

Promotor: Prof.dr. E. F. van Dishoeck

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

For each living organism health is ensured by correct functioning of its cells. Cells therefore have elaborate methods for regulation of their proteins.

Promotor: Prof.dr. W.Th.F. den Hollander, Co-promotor: R. Fernandez.

Yearly, the LIBC organizes a public event to share scientific research in the field of brain & cognition These public days are organized in collaboration with the municipality of leiden in the City Auditorium.

This course explains the functions of each international court and tribunal in The Hague. On the basis of cases and interviews with judges and lawyers, this course explores the role of these courts and tribunals and their potential to contribute to global justice.

The aim of this thesis is to present novel techniques for proving cryptographic schemes secure against quantum adversaries. Most results are within the context of an idealized model called the ‘quantum random-oracle model’.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

Artificial intelligence algorithms govern in subtle, yet fundamental ways, the way we live and are transforming our societies. The promise of efficient, low‐cost or ‘neutral’ solutions harnessing the potential of big data has led public bodies to adopt algorithmic systems in the provision of public…

Beneficial plant-associated microbiota, particularly those inhabiting the rhizosphere, contribute substantially to plant health through pathogen suppression, stimulation of plant defence responses, and enhanced nutrient acquisition.

Eveline Crone is lang niet de enige professor puberbrein op het internationale FLUX-congres. Leiden was vier dagen lang het centrum van onderzoek naar hersenontwikkeling. Opvoeders en beleidsmakers ontmoetten wetenschappers tijdens het publiekssymposium op 18 september.

Cognitieve psychologie is de studie van mentale functies, waaronder aandacht, geheugen, bewustzijn, emotie, taal en actiecontrole. Het doel is om de complexe relaties tussen brein, cognitie en gedrag te begrijpen.

Promotor: S.M. Verduyn Lunel

We developed the bitterling as a unique, well-studied model organism in the area of the evolutionary ecology of brood parasitism. The bitterling-mussel relationship, interspecific mussel host preference, and mussel gill structure are studied in detail, to help understand the developmental adaptation…

Neurodegenerative diseases pose a large medical and societal challenge. The etiology of these diseases is still poorly understood, which makes drug discovery for these diseases difficult.

Lezing

Samen met breinwetenschapper Rebecca Schaefer kijken naar het effect van muziek op het brein van een proefpersoon. Daarvoor komen mensen naar de LIBC-publieksdag, en voor meer verhalen van topwetenschappers over hun onderzoek naar muziek. De vijf rietblazers van Calefax stelen de show, het Nederlands…

The studies in this thesis are focused on the physical effects in the flat band materials. The results contain the discovery of strong enhancement of RKKY spin-spin interactions with specific geometric arrangement and dynamical generation of excitonic order parameter with high magnitude.

The thesis explores how interstellar chemistry evolves as a function of time and changing physical architectures during the formation of stars.

Promotores: Prof.dr. J. Schaye, Prof.dr. S.D.M. White (MPA Garching)

Evolution acts via mutations in amino acid sequences. Substitution of essential amino acids leads to a nonfunctional protein. l.

Het identificeren van veranderingen in de hersenen die verband houden met suïcidale gedachten en gedragingen (STB's) bij jongeren is van cruciaal belang om de ontwikkeling ervan te begrijpen en vroegtijdige interventie en preventie te verbeteren.