Doorstroomprogramma speciaal voor tweedegraadsbevoegde docenten Duits.

Doorstroomprogramma speciaal voor tweedegraadsbevoegde docenten Engels.

Promotor: P.M. Brakefield

De vakken die het VVI aanbiedt zijn onderdeel van het bredere onderwijsprogramma van de Faculteit der Rechtsgeleerdheid, dat programma’s aanbiedt op bachelor- (LLB) en masterniveau (LLM, Advanced Studies, PhD). Het instituut geeft een in Europa uniek MSc programma Law and Society: Governance and Global…

In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

What are the pressing issues of our time, and how can different disciplines come together to address them? Studium Generale and Leiden University College (LUC) present the Global Challenges series: events that bring together researchers from LUC and experts from other disciplines to tackle a shared…

We have examined sequences from the ligand-binding domain of the nicotinic acetyl choline receptor (nAChR) in 148 vertebrate species. We are in interested in this receptor because the α-neurotoxins of many venomous snakes binds to this receptor in its location at the neuromuscular junction in all ve…

Promotores: Prof.dr. H Lenstra, Prof.dr. A Facchini (Padova University)

Promotores: R. Cramer, A.K. Lenstra, Co-Promotor: B.M.M. de Weger

Over the last decades, aviation safety has improved strongly. As a downside, airline pilots do not have as many opportunities to develop through experience the competencies that they need in critical situations.

Promotor: Prof.dr. E.F. Smets. Co-promotores: B. Gravendeel, F. Pupulin

Promotor: J. Zaanen, Co-Promotor: V. Juricic

Promotor: Christoph U. Keller, Co-promotores: Matthew A. Kenworthy, Frans Snik

Promotor: S.M. Verduyn Lunel

There is concern about the threat that nanoplastics (NPs) may pose to both wildlife and humans. This thesis explores the mechanisms of toxicity of polystyrene nanoparticles (PS-NPs) in chicken embryo.

Stars like the sun are born in large molecular clouds existing from gas and dust. During the formation process, the chemical composition of the material can be altered drastically by the changing physical conditions.

The complexity of an intelligence problem determines to a great extent the certainty that can be provided by intelligence and security services.

Azië en Europa hebben in toenemende mate met elkaar te maken. Om een duurzame samenwerking te bevorderen is het belangrijk elkaar op economisch, sociaal-cultureel, historisch, en juridisch gebied beter te begrijpen. Leidse wetenschappers leveren al decennia een belangrijke bijdrage aan de verwerving…

Investigating the intercultural connections that shaped practices of knowledge production in colonial Dutch Brazil.

Urbanisation is steadily increasing with estimates expecting that 68% of the global population will live in cities by 2050. To accommodate the rural to urban transition, large quantities of land are transformed from natural to urban lands.

This thesis contains results on the arithmetic and geometry of del Pezzo surfaces of degree 1.In Chapter 1 we give the necessary background, assuming the reader is familiar with algebraic geometry.

In this thesis, single-cell approaches were applied to characterize the impact of aging on the immunological B cell landscape in different models of atherosclerotic cardiovascular disease, with the goal to identify and study new B cell-associated biomarkers and therapeutic targets to halt atherosclerosis…

In this thesis we study the moduli space of genus g curves, and the differential forms that occur naturally on this moduli space.

This thesis is is made of three parts. The first part describes a generalization of the Chabauty's method, that can be used to determine the rational points of a curve such that s+g>r+1, where g is the genusof the curve, r is the rank of the Mordell-Weil group of the jacobian of the curve and s is…

This thesis describes how different colours of light affect various aspects of the growth and development of Arabidopsis and tomato plants⁠.

Promotor: A. Doelman, Co-promotores: P.J.A. van Heijster; A. Zagaris

In this thesis, we have used numerical approaches to study the effects of translational symmetry breaking on strange metallic systems as realised by the holographic duality⁠.

Prof.dr. P. Stevenhagen, Prof.dr. K. Belabas (Universite Bordeaux I)

Promotores: H.W. Lenstra, A. Lucchini

Although plant domestication has significantly altered crop genetics and phenotypes, its effects on the taxonomic and functional diversity of plant-associated microbiomes are not well understood.

This thesis is dedicated to the exploration of the primordial dark ages: unknown physics during the earliest stages of the Universe’s expansion that have not yet been directly probed by observations. Cosmic inflation is a burst of exponential expansion of space after the “Big Bang”.

Binnen het brede netwerk van de Universiteit Leiden neemt het instituut deel aan onderzoek binnen de volgende profileringsgebieden:

Commerciële bedrijven die gebruik willen maken van de expertise en faciliteiten worden doorverwezen naar LAB , de commerciële eenheid die verantwoordelijk is voor gespecialiseerd laboratoriumwerk.

In vroegmiddeleeuws Engeland was er belangstelling voor de geschiedenis van het Romeinse Rijk en koningen namen imperiale titels als 'imperator' en 'basileus' over. Hoe kunnen we deze interesse verklaren en welke functies hadden imperiale ideeën en de ontvangst van de klassieke wereld in vroegmiddeleeuws…

To contribute to the body of knowledge aiming at a better coverage of ecosystem service assessment in LCA studies, this thesis dives into the challenges of incorporating existing ecosystem service methods within the impact assessment phase of the conventional LCA framework.

When a star gets too close to a supermassive black hole, it is torn apart by strong tidal forces in a tidal disruption event (TDE).

Promotor: J. N. Kok, Co-promotor: A. J. Knobbe

In astronomy, the interpration of observations and measurements plays a crucial role: we rely purely and fundamentally on the information that reaches us as observers. And 80% of all matter in the universe is undetectable directly.

This dissertation presents the synthesis and evaluation of antibody recognition for various capsular polysaccharide (CP) fragments of Staphylococcus aureus (S. aureus).

Pulsars were first discovered in 1967 and since then the population has grown and expanded over several wavelengths.

Solar energy is used by photosynthetic organisms to drive energy required cellular processes. Is absorbed by two groups of pigments, located in the LHCs.

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

The physical origin of the dozens of stellar-mass binaries, the mergers of which have been detected by the LIGO-Virgo-KAGRA collaboration via gravitational waves, is still unknown.

This dissertation presents new cryptographic protocols, which can be divided into two families.

Promotor: J.W.M. Frenken

Plants, are sessile organisms, have developed strategies to adapt to changes in their environment, in part by altering their growth and development.

If X is a locally compact Hausdorff space, then a representation of the complex C* algebra C_0(X) on a Hilbert space $H$ is given by a spectral measure that takes its values in the orthogonal projections on $H$.

Humans can see the world through the eyes of other humans and imagine what they know, want, and intend. This competence is known as Theory of Mind.