Human civilization consumes a huge amount of fossil fuels, which has resulted in an atmospheric CO2 level which has not been higher in over 800 millennia.

Overzicht van de belangrijkste papyrologische websites

In deze bundel wordt verslag gedaan van onderzoek op het gebied van duurzaamheid, uitgevoerd aan de Leidse rechtenfaculteit.

Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi

Ethiopian wolves are endangered diurnal Afroalpine rodent hunters. I investigated the interaction between wolves, rodents and human land use in Borena Sayint National Park (BSNP), Abune Yosef and Aboi Gara in Ethiopia.

Promotores: G.R. de Snoo, W.T. de Groot, Co-promotor: C.J.M. Musters

Promotores: F.H. van Lunteren, F.P. Israel

Obesity may alter how a person absorbs, distributes, metabolizes or excretes medication. This thesis describes how obesity affects drug levels in the blood for antimicrobial agents, such as ciprofloxacin and fluconazole.

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

Where does the urge to collect come from? What are the explicit or underlying reasons for gathering large amount of objects?

Promotores: G. Persoon, R. Schefold

Het doel van het RAISE Onderzoek is om te onderzoeken hoe veerkrachtige mensen omgaan met stress. We kijken specifiek naar hoe belangrijke biologische systemen, zoals de HPA-as en het immuunsysteem, samenwerken met de hersenen en de sociale omgeving om veerkrachtig functioneren na moeilijkheden in de…

Promotor: J. Kuiper

Dit project gaat over hoe gebarentalen in de loop van de tijd veranderen en zich verspreiden, en hoe dit wordt beïnvloed door hun overdrachtsgeschiedenis.

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

Op zaterdag 25 mei wordt in het Museon in Den Haag de internationale, reizende tentoonstelling Caribbean Ties geopend. De tentoonstelling vertelt het onbekende verhaal van inheemse bewoners in het Caribisch gebied, en over hun leven vóór, tijdens en na de Europese kolonisatie. Caribbean Ties is gelijktijdig…

Lezing

Wereldwijd zijn er ruim 7000 talen; meer dan de helft van de wereldbevolking is meertalig. Maar hoe gebruiken al die mensen hun taal? En op welke vlakken verschillende deze taken van elkaar? Onder het motto ‘Interconnecting linguistic diversity’ zijn de onderzoekers van het Leiden University Centre…

Gedeelde identiteit, de vorming van onze jeugd en toekomst, ontwikkeling van wetenschap en techniek: over zulke gevoelige onderwerpen gaat het in het onderzoek naar 100 jaar Ministerie van Onderwijs, Cultuur en Wetenschap (OCW).

We verwelkomen gastwetenschappers wier onderzoek aansluit bij onze uiteenlopende expertisegebieden. De tekst gaat verder in het Engels.

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

Met ons onderzoek en onderwijs dragen we bij aan een betere wereld. We mengen ons in het wetenschappelijke en publieke debat, en zoeken antwoorden voor economische en maatschappelijke vraagstukken. Zowel lokaal en regionaal als mondiaal.

To contribute to the body of knowledge aiming at a better coverage of ecosystem service assessment in LCA studies, this thesis dives into the challenges of incorporating existing ecosystem service methods within the impact assessment phase of the conventional LCA framework.

Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: M.R. Hogerheijde

In this thesis,

Promotor: Prof.dr. S. Haring

In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

Graphene nanoribbons (GNRs) are used as a current carrying substrate in investigation of current-induced forces in a low-temperature STM (chapter 2).

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

Promotor: Prof.dr. A.G.G.M. Tielens

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Promotor: P.D. Grünwald

Promotor: A. Achúcarro, Co-promotor: A. Boyarsky

The theoretical explanation of cosmic acceleration is nowadays one of the biggest puzzles in cosmology.

Scattering of light in the presence of nano-structured materials, i.e. with features in the order of the wavelength of the light or smaller, reveals details of how light interacts with matter at the nanoscale.

The expedition commanded by Nicolas Baudin to Tenerife, Mauritius, Australia, Timor and South Africa in 1800-1804 is fully researched in regard to ornithology.

Vinasse is a major by-product generated by the sugarcane biofuel industry. It is a source of microbes, nutrients and organic matter and often it is recycled as fertilizer.

This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…

Trigonostemon Blume is a plant genus in the family Euphorbiaceae comprising 59 species.

Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.

A new publication on changes in the relationship between news and their public in Chile

Promotor: Prof.dr. C.W.J. Beenakker

The explosive radiation and diversification of the advanced snakes (superfamily Colubroidea) was associated with changes in all aspects of the shared venom system. Morphological changes included the partitioning of the mixed ancestral glands into two discrete glands devoted for production of venom ormucous…

The prevalence of obesity (BMI >40 kg/m2) has increased rapidly over the recent years, not only in adults, but also in children and adolescents.

Glucocorticoids are potent anti-inflammatory drugs widely used clinically to treat various inflammatory and immune conditions. However, two main clinical problems limit their use. GCs trigger severe side effects and they induce acquired glucocorticoid resistance, especially during chronic systemic treatment…

Cardiovascular syndromes are the major cause of death in Western societies.

Promotor: Prof.dr. J.M. van Ruitenbeek, Prof.dr. R.M. Tromp

Healthy aging is one of the prime goals in today's society and atherosclerosis is among the greatest causes of morbidity in elderly. Cardiovascular disease patients receiving treatment are often of advanced aged and have an aged immune system, which limits translating experimental findings to the pa…