Large carnivores and humans, along with their livestock, have co-existed for thousands of years. However, human population growth and an increase in economic activities are modifying the landscape for large carnivores and their prey.

Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.

This thesis applies data mining in commercial settings in the telecommunications industry.

Natural vanilla flavor is one of the most important in the world. However, the cost of this flavor is expensive. Production of this flavor by alternative methods, could reduce the cost.

Promotor: J. A. Bouwstra

Plants produce an astonishing variety of secondary metabolites (SMs) which are thought to play vital roles in the fitness of plants through ecological interactions.

De eerste Nederlandse bijdrage aan de toekomstige European Extremely Large Telescope (E-ELT) is succesvol getest. Het gaat om de 'chopper', een zeer wendbaar spiegeltje dat is ontwikkeld door een samenwerkingsverband van universiteiten, technologische instituten en het bedrijfsleven. Het high techspiegeltje…

Promotor: G.R. de Snoo, Co-promotor: H.H. de Iongh, C.J.M. Musters

CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

Lezing, Haags Actualiteitencollege

Op 4 december werd de exoplaneet aan de astronomische wereld gepresenteerd, die eind vorig jaar door drie Leidse studenten onder leiding van Ignas Snellen is ontdekt. Het blijkt een uniek object te zijn, een stuk groter dan Jupiter, en met bijna vijf keer zijn massa.

This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors.

Promotor: E. Bouwman, Co-Promotor: S. Bonnet

This thesis describes the implementation and on-sky demonstration of high-resolution integral-field spectroscopy for extreme adaptive optics systems that are used to find and characterize exoplanets.

This thesis presents the results of a study on the interfaces of insulating oxides with and without the insertion of a magnetic layer.

The research described in this thesis centered on retaining exo-β-glucosidases implicated in health and disease, in particular the human inherited lysosomal storage disorder, Gaucher disease (GD).

The main research question of this thesis was: Can nitrogen cycling on dairy farms on peat soil in the Dutch Green Heart area be improved by adapting management to the nitrogen supply from soil and by using other grassland species and crops without affecting milk production?

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

Mycoheterotrophy is a particular mode of life in which plants obtain carbohydrates from their associated fungal partners, instead of by using photosynthesis.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Traditionally, vaccines are administered intramuscularly using conventional hypodermic needles, which cause pain and distress. Microneedles are very short needles (smaller than 1 mm) that are practically invisible to the naked eye.

This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.

Promotor: T. Hankemeier, Co-promotor: T.H. Reijmers

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

Promotor: A.P.IJzerman Co-promotor: A. Bender

In this thesis, we address two problems concerning the tautological rings of the moduli space of curves.

Wil je meer weten over globalisering? In de Engelstalige bachelor International Studies van Universiteit Leiden kies je een wereldregio en bestudeer je hoe regionale thema’s en gebeurtenissen in een mondiale context geplaatst kunnen worden. Hiervoor gebruik je kennis en vaardigheden uit de disciplines…

We have examined sequences from the ligand-binding domain of the nicotinic acetyl choline receptor (nAChR) in 148 vertebrate species. We are in interested in this receptor because the α-neurotoxins of many venomous snakes binds to this receptor in its location at the neuromuscular junction in all ve…

This thesis describes the synthesis, analysis of various tetrazine bearing compounds and use in bioorthogonal chemistry.

Japan kent niet alleen een rijke geschiedenis en eeuwenoude tradities, maar is ook één van de grootste economieën ter wereld. Bij Japanstudies verdiep je je intensief in het heden en het verleden van het land en de Japanse maatschappij, met kennis van de taal als jouw basis. Leer de wereld áchter de…

Promotores: W.J.G.M. Peijnenburg, G.R. de Snoo, Co-promotor: M.G. Vijver

The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…

This thesis explores interfacial conductance and electric field-effects in LaAlO3/SrTiO3 heterostructures.

Promotor: Prof.dr. M. Ubbink

The International Course on Water Use and Management in Cagayan Valley The Philippines (2011-2015)

This thesis presents the systematics, epidermal defense, and bioprospecting of wild orchids.

Promotor: F.J. van Lunteren, E. Jorin

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

To gain more insight into the evolutionary development of orchid flowers and fruits, the orchid species Erycina pusilla was studied. The evolutionary origin of the median petaloid sepal, the callus on the labellum, and the stelidia was studied.

Het is de grootste structuur in het heelal: een duizelingwekkend web van materie dat sterrenstelsels zoals de Melkweg onderling verbindt. De Leidse Joop Schaye en Michael Maseda waren twee van de astronomen die hielp een piepklein stukje van dit 'kosmische spinnenweb' in beeld te brengen. In de Volkskrant…

Wil jij meer weten over Japanstudies aan Universiteit Leiden? Bekijk de opleidingsvideo over deze bachelor.

Niet altijd werd in Japan Japans gesproken. Wetenschappers verbinden de komst van de taal naar Japan met de migratie van boeren rond 400 v. Christus. Taalkundige Elisabeth de Boer gaat met een ERC Starting Grant onderzoek doen naar de verdere verspreiding van de taal in Japan.

In de bachelor Japanstudies leer je het land vanuit verschillende wetenschappelijke disciplines te bestuderen, namelijk: antropologie, film en media, geschiedenis, internationale betrekkingen, literatuur, kunst en materiële cultuur, politieke economie en sociologie. Ook leer je de Japanse taal en het…

The formation and evolution of galaxies is fundamentally driven by the formation of new stars out of cold gas.

I have studied the hot, diffuse gas around and between galaxies. Specifically, I have used the EAGLE numerical simulations of galaxy formation to predict the properties of this gas, and I have used those properties to predict specific observables: soft X-ray absorption and emission lines.