Promotor: Prof.dr. G.P. van Wezel

Vinasse is a major by-product generated by the sugarcane biofuel industry. It is a source of microbes, nutrients and organic matter and often it is recycled as fertilizer.

Cardiovascular syndromes are the major cause of death in Western societies.

Heart failure is a major health care problem with high mortality.

Advanced UHF MRI techniques provide powerful tools for studying the zebrafish brain, an emerging model in neurological research. In this work, various MRI and localized MRS methods are optimized and employed for UHF strength for studying the zebrafish brain.

Promotor: J.A. van Veen, Co-promotor: E.E. Kuramae

Promotor: Prof.dr. J. den Hertog

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals.

Promotor: S.M. Verduyn Lunel, Co-promotor: O. van Gaans

Promotor: Prof.dr. T. Schmidt

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

Optimization tasks in practice have multifaceted challenges as they are often black box, subject to multiple equality and inequality constraints and expensive to evaluate.

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

Enzymes are innately sensitive to changes in the amino acid sequence, which largely constrains their evolutionary potential, i.e., evolvability. This evolutionary burden can be alleviated in the presence of stabilizing mutations, which increase the buffering capacity of enzymes to tolerate mutations…

This thesis discusses several questions regarding the double ramification cycle as a Chow class on the moduli space of stable n-pointed genus g curves using tools from so-called logarithmic geometry.

Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.

Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…

Promotor: Prof.dr. E. F. van Dishoeck

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

For each living organism health is ensured by correct functioning of its cells. Cells therefore have elaborate methods for regulation of their proteins.

Promotor: Prof.dr. W.Th.F. den Hollander, Co-promotor: R. Fernandez.

Standaard schooltesten als de CITO-toets laten vooral zien wat kinderen al goed kunnen. Dynamische testen geven juist inzicht in hun potentieel om te leren, ontdekte Mirjam de Vreeze in haar promotieonderzoek. Vooral bij kinderen met leerproblemen als dyslexie of faalangst biedt dat perspectief.

De ziekte van Parkinson is een neurodegeneratieve aandoening die niet alleen wordt gekenmerkt door motorische symptomen, maar vaak ook gepaard gaat met cognitieve problemen. In deze pilotstudie zal worden onderzocht in hoeverre digitale thuistesten een haalbare en effectieve aanvulling kunnen zijn op…

This course explains the functions of each international court and tribunal in The Hague. On the basis of cases and interviews with judges and lawyers, this course explores the role of these courts and tribunals and their potential to contribute to global justice.

The aim of this thesis is to present novel techniques for proving cryptographic schemes secure against quantum adversaries. Most results are within the context of an idealized model called the ‘quantum random-oracle model’.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

Artificial intelligence algorithms govern in subtle, yet fundamental ways, the way we live and are transforming our societies. The promise of efficient, low‐cost or ‘neutral’ solutions harnessing the potential of big data has led public bodies to adopt algorithmic systems in the provision of public…

Beneficial plant-associated microbiota, particularly those inhabiting the rhizosphere, contribute substantially to plant health through pathogen suppression, stimulation of plant defence responses, and enhanced nutrient acquisition.

Geldzorgen hebben impact op je brein. Wie denkt eigen schuld, dikke bult, heeft het mis. Gedrags- en neurowetenschapper Mirre Stallen legt in een video van Universiteiten van Nederland uit waarom schulden niet altijd je eigen schuld zijn.

Deze serie benadert begrijpend lezen vanuit een cognitief perspectief. We beschrijven hoe lezers tot begrip komen. Dat wil zeggen: hoe zij coherente mentale representaties opbouwen tijdens het lezen van tekst.

In twee afleveringen van Radio Zwammerdam vertelt hoogleraar cognitieve gedragsecologie Karline Janmaat over voedselzoekgedrag van chimpansees. Met touchscreens en voedselpuzzels onderzocht ze samen met Max Boot hoe apen naar voedsel leren zoeken.

Larissa Mendoza Straffon en collega's onderzochten visuele aandachtsbiases ten opzichte van zelfgemaakte kunstwerken, die de neiging hebben om bevoordeeld, herinnerd, gewaardeerd en gerangschikt te worden boven en boven objecten die geen verband houden met het zelf. Hun bevindingen bevestigen dat aandacht…

Onderzoekers van de Universiteit Leiden werken samen met Ouwehands Dierenpark om beter inzicht te krijgen in de emoties en intelligentie van orang-oetans. Het publiek van de dierentuin kan nu zien hoe orang-oetans zich uitleven op computer-touchscreens.

The studies in this thesis are focused on the physical effects in the flat band materials. The results contain the discovery of strong enhancement of RKKY spin-spin interactions with specific geometric arrangement and dynamical generation of excitonic order parameter with high magnitude.

The thesis explores how interstellar chemistry evolves as a function of time and changing physical architectures during the formation of stars.

Promotores: Prof.dr. J. Schaye, Prof.dr. S.D.M. White (MPA Garching)

Evolution acts via mutations in amino acid sequences. Substitution of essential amino acids leads to a nonfunctional protein. l.

Het onderzoek van het Resilience Center gaat over geestelijke gezondheidsrisico's en veerkracht bij jongeren. We doen dit door culturele, sociale, cognitieve en neurobiologische factoren en hun interacties te integreren.

Het REViVE-subproject richt zich op de periode waarin vrouwen overgaan van hun vruchtbare jaren naar de menopauze: de perimenopauze.