The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

Promotor: Prof.dr. A.W. van der Vaart

Carbon dioxide capture and utilization technologies are necessary to create a truly circular economy. The electrochemical reduction of carbon dioxide to formate is an appealing carbon utilization method as it can be performed at room temperature and pressure, it only requires two electrons, and it has…

In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.

Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi

Promotor: Prof.dr. M. Danhof

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

Promotor: W. Jiskoot, Co-promotor: A. Hawe

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua

Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.

Op 6 oktober 2021 heeft Simone van der Hof een lezing gegeven over age verification and age appropriate design.

Stimulerende drugs als khat en cocaïne hebben negatieve impact op dagelijkse handelingen als autorijden, werk of sociaal gedrag. Dat komt door beschadiging van controlefuncties in de hersenen. Psycholoog Manuel Ruiz draagt bij aan beter begrip en behandeling van drugsmisbruik. De Spanjaard Ruiz promoveert…

Op 7 oktober 2021 was Simone van der Hof te gast bij een online talkshow in het kader van de Dutch Media Week met als thema het onderzoek waaraan zij werkt met Tony van Rooij van het Trimbos Instituut en Max Birk van de TU Eindhoven: Behavioral Design in Video Games.

Op 17 november 2017 gaf professor Simone van der Hof een duo-lezing met haar collega Professor Eva Lievens van de Universiteit Gent tijdens de ‘Children and Digital Rights’ conferentie aan het Information Law and Policy Centre, dat onderdeel is van het Institute of Advanced Legal Studies (University…

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

Promotor: Prof.dr. M. Ubbink

Simone van der Hof, hoogleraar Recht en Digitale Technologie bij eLaw, is als expert toegetreden tot de EU Special Group on Code of Conduct for age-appropriate design.

Over the last decades, aviation safety has improved strongly. As a downside, airline pilots do not have as many opportunities to develop through experience the competencies that they need in critical situations.

This thesis addresses the problem of designing performance and energy efficient embedded streaming systems, that is, systems which process a stream of input data coming from the environment and generate a stream of output data going into the environment.

Promotors: Prof.dr. T.H.W. Bäck, Prof.dr. B. Sendhoff (Technische Universität Darmstadt)

Lipid formulations have demonstrated strong potential for nucleic acid delivery,particularly with the success of COVID-19 vaccines. Despite these advances, manyaspects of lipid formulations remain unclear.

Membrane fusion is a vital process in living organisms and is mediated by zipper-like proteins.

Promotores: W. Jiskoot, F. Ossendorp

Nanodiscs are small, disc-shaped structures designed to mimic biological cell membranes, composed of a lipid bilayer stabilized by scaffold proteins. Membrane proteins play crucial roles in essential processes such as nutrient and waste transport, molecular recognition, and cell signalling, making them…

Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot

Op de eerste dag van jouw nieuwe baan heb je zweethanden, ben je nerveus en onzeker, maar een paar maanden later zijn die gevoelens al weer verdwenen. Je hebt jouw nieuw rol eigen gemaakt en je bent nu onderdeel van de organisatie. Het proces dat daar naar toe leidt heet

A framework for prospective/ex-ante life cycle assessment (LCA) and ecological risk assessment (ERA) of emerging technologies is developed and applied to a case study of III-V/silicon photovoltaic panels.

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

Promotor: E. Bouwman, Co-promotor: S. Bonnet

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

Drug development critically depends on preclinical models that mimic human physiology, yet traditional two-dimensional cultures and animal models often lack predictive power.

This thesis aims to address offshore wind energy (OWE)-related environmental impacts.

This thesis focuses on addressing four research problems in designing embedded streaming systems.

Tijdens de jaarlijkse Wetenschappelijke Dag van de Sectie Farmacochemie van de KNCV in Weesp werd de Nederlandse Farmacochemieprijs uitgereikt aan Dr. Tom Wennekes, voor zijn proefschrift, getiteld: ‘Lipophilic iminosugars: synthesis and evaluation as inhibitors of glucosylceramide metabolism’.