Promotor: Prof.dr. A.G.G.M. Tielens

To study how planetary systems come into existence we study much younger systems still in formation.

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Arithmetic geometry concerns the number-theoretic properties of geometric objects defined by polynomials. Mathematicians are interested in the rational solutions to these geometric objects.

There are many interpretations of quantum mechanics, and ultimately experiments are needed to verify or falsify these interpretations.

In this thesis, I study the formation of large-scale structure and the physics of particle acceleration at large scales (~Mpc).

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

Science is typically a patchwork of research contributions without much coordination. Especially in clinical trials, the follow-up studies that we do fail to be the most promising.

In this thesis we study the landscape of gravitational models which modify GR by introducing an additional scalar degree of freedom (d.o.f.) to source Cosmic Acceleration.

Molecular materials have been a subject of interest in fundamental research and applications for decades, and have been studied as bulk crystals, (thin) films and as individual molecules, due to the large variety in their properties. This dissertation explores pentacene crystals near the two-dimensional…

Promotor: Prof.dr. B.R. Katzy, Prof.dr. J. de Vries

In the early universe, the dynamics of the Higgs field can give rise to many interesting phenomena.

Binnen dit instituut wordt veel gevangenisonderzoek verricht. Detentie is de strengste sanctie die in de strafrechtstelsels van de Europese landen wordt toegepast.

Studievoorlichting

Studievoorlichting

Dit op casestudies gebaseerde Engelstalige boek over multivariate analyse voor gevorderde studenten in de geesteswetenschappen legt de nadruk op beschrijvende, exploratieve analyses van verschillende soorten datasets uit een breed scala van subdisciplines, waarbij het gebruik van multivariate analyse…

Promotor: Prof. dr. A.G.G.M. Tielens

Binnen het brede netwerk van de Universiteit Leiden neemt het instituut deel aan onderzoek binnen de volgende profileringsgebieden:

The thesis is about the study of shell evolution of the Hydrocenidae of the genus Georissa. This thesis started with a general overview on the evolutionary process of animals due to ecological changes.

This dissertation is part of a broader research project that revolves around unraveling the evolution of balanced lethal systems.

The European Council and the European Commission have a similar role in agenda setting. Both place issues on the EU agenda. However, these institutions have distinct designs. They have different political attributes (the European Council has considerably more political authority) and information-processing…

This dissertation is a collection of four research articles devoted to the study of Kummer theory for commutative algebraic groups.

In this thesis we study products of linear error correcting codes.

The Low Frequency Array enables studies of low-frequency carbon radio recombination lines with unprecedented sensitivity, spectral and spatial resolution.

De toekomst van islam in Nederland

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

To get an idea of the science communication products and research that is possible, a few examples of student projects of recent years are shown below.

The mission of our group is understanding how science communication works to improve the interaction between science and society. We believe better science communication can improve our society and engage many different groups with science, also improving science.

Learning from small data sets in machine learning is a crucial challenge, especially when dealing with data imbalances and anomaly detection. This thesis delves into the challenges and methodologies of learning from small datasets in machine learning, with a particular focus on addressing data imbalances…

Promotores: Prof.dr. J. Zaanen, Prof.dr. K.E. Schalm

Religious Studies at Leiden University allows you to study a broad spectrum of religions and their manifestations.

Een lijst met wetenschappelijke publicaties samengesteld door het team van het TRIXY Expertisecentrum.

Een chemokuur die niets doet, totdat je hem met licht bestraalt. Voor de ontwikkeling daarvan ontving Sylvestre Bonnet een Vici-beurs van 1,5 miljoen euro. Hiermee 'bouwt' de Leidse chemicus een nieuw molecuul om tumoren te bestrijden die nu nog lastig te behandelen zijn.

Het Leids Studiesysteem biedt goede begeleiding bij je studiekeuze én tijdens je studie. Samen maken we van jouw studie een succes.

Promotor: G.P. van Wezel

DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.

This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…

The plant hormone auxin regulates plant growth and development through polar cell-to-cell transport-generated maxima and minima. PIN FORMED (PIN) auxin efflux carriers determine the direction of this auxin flow through their asymmetric placement on the plasma membrane (PM).

Leerlingen uit de bovenbouw van het vwo binden de strijd met elkaar aan op het Max Havelaar Toesprakentoernooi. Het doel: een topspeecher worden, je verdiepen in fairtrade én het werk van Multatuli beter leren kennen.

In the last decade, the redox interconversion between metal thiolate and disulfide compounds has been extensively investigated for copper, but not for other transition metal ions.

Promotores: Prof.dr. G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij

De universitaire Visie op Studentenwelzijn geeft richting aan de manier waarop de universiteit het welzijn van haar studenten de komende jaren wil bevorderen.

This thesis focuses on enhancing predictions of central nervous system drug exposure using the LeiCNS-PK3.0, a physiologically based pharmacokinetic model.

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

Despite the history of studies on methanol formation from CO2, the dominant elementary reaction steps that constitute the chemical mechanism for this catalyzed process are not determined.

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…