Promotor: K.J. Batenburg, Co-promotor: A.W. van der Vaart, B. de Smit

Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe

Natural vanilla flavor is one of the most important in the world. However, the cost of this flavor is expensive. Production of this flavor by alternative methods, could reduce the cost.

Cristina Grasseni’s project

This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.

This thesis provides an overview of the development of the Pair Configuration to Molecular Activity Coefficient (PAC-MAC) model.

The thesis focuses on synthesis strategies in oligosaccharide campaigns, and the influence of protecting groups.

The idea of citizens and public professionals collaborating to provide public services has widely spread in several countries around the globe. Co-production is often presented as the go-to solution for challenges like a legitimacy crisis of both the government and the market, and financial concerns.…

Why do sexual violence policies still fail to systematically address men and masculinities, when the need for cultural change among men has been central in public debates since #MeToo?

Material circularity and energy efficiency are highly relevant and intertwined issues for the transition towards a carbon-neutral and circular built environment. In the Netherlands, the building sector has been rendered a priority towards a circular and low-carbon society.

Promotor: Prof.dr. M. Ubbink

Dit project onderzoekt de professionalisering van universiteitsbibliotheken in de negentiende en vroege twintigste eeuw, door de lens van het middeleeuwse handschriftenbezit. Met de Leidse Universiteitsbibliotheek als uitgangspunt werpt het licht op de veranderende praktijken rond het conserveren, behandelen…

Het Leiden University Centre for Digital Humanities (LUCDH) heeft per 1 februari een nieuwe directeur. Universitair hoofddocent Angus Mol wil in zijn nieuwe rol mensen en kennis verbinden.

Traditional hypothesis testing requires researchers to set a fixed sample size in advance. After collecting data, the test determines whether to reject the null hypothesis.

In this book liposomes are explored as delivery system for allergen-specific immunotherapy. Both cationic and anionic formulations are prepared with Bet v 1, one of the allergens in birch pollen.

Promotor: Prof.dr. M. Ubbink, Co-promotor: G. Siegal

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

In this thesis,

Promotor: P.D. Grünwald

In meta-analysis, heterogeneity often exists between studies. In such cases, it is essential to investigate the sources of heterogeneity and understand the relationship between effect size and study characteristics (i.e., moderators).

Image segmentation is a fundamental task in computer vision, with applications ranging from medical diagnostics to archaeological research.

Throughout the history of computer science, a major challenge has been how to assert that software is free of bugs and works as intended. Software bugs can lead to serious negative impacts on any software system. Throughout the main body of the thesis, we implemented a series of studies on exploring…

This thesis studies the geometry of representation varieties and character stacks. These are spaces parametrizing the representations of a finitely generated group, typically the fundamental group of a compact manifold, into an algebraic group G.

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

Novel entities may pose risks to humans and the environment. The small particle size and relatively large surface area of micro- and nanoparticles (MNPs) make them capable of adsorbing other novel entities, leading to the formation of aggregated contamination.

In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.

Building a Deep Cross-media Transfer Network to extract visual relations that relieve the problem of insufficient training data for visual tasks.

Predictive maintenance (PdM) is a maintenance policy that uses the past, current, and prognosticated health condition of an asset to predict when timely maintenance should occur.

Promotor: W.Th.F. den Hollander Co-Promotor: F.M. Spieksma

Promotor: R. Verpoorte, Co-promotores: Y.H.Choi, N.R. Mustafa

Promotor: J.N. Kok, P.E. Slagboom Co-promotor: J.F.J. Laros

In some condensed matter systems, such as the surface of a 3D topological insulator, the electrons are effectively massless and we must necessarily use the massless Dirac equation to describe them.

In my research, we developed a method to distinguish knots. A knot is a mathematical depiction of the everyday knot that occurs in ropes and cords.

Promotor: Thomas Hankemeier, Co-promotores: Heiko van der Linden, Paul Vulto

In the first part of this thesis we study the geometry of folding patterns.

African oral literatures, new media and technologies: challenges for research and documentation

This thesis covers various applications of topology in condensed matter physics and quantum information.

Onderzoekers van meer dan 30 landen namen deel in het Europese onderzoeksnetwerk E-READ om de veranderingen in het lezen door digitalisering te bestuderen. Adriaan van der Weel, universitair hoofddocent, sprak over het succes van het netwerk met de Duitse krant Frankfurter Allgemeine Zeitung.

John Boy en zijn collega's van het d12n-onderzoekscluster krijgen een beurs van het Digital Infrastructure Insights Fund D//F.

Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…

Freshwater biodiversity has been threatened by eutrophication due to excessive nutrients in the environment. Releasing the freshwater species from such pressures requires efforts from industry and manufacturers to avoid emissions to vulnerable and high-risk regions.

This thesis mainly focuses on cross-modal retrieval and single-modal image retrieval via deep learning methods, i.e. by using deep convolutional neural networks.

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

This thesis covers several aspects of quantum algorithms for near-term quantum computers and its applications to quantum chemistry and material science.

In this thesis, we have studied cell images from two types of cells, including pollen grains and the immune cells, neutrophils. These images are captured using a bright field microscope and a confocal microscope.

Teaching the Future: AI-Enhanced Education for Student Engagement and Ethical Learning.

The main theme of this thesis is the theoretical study of Gaussian processes as a tool in Bayesian nonparametric statistics.