Heterogeneous catalysis is one of the fundamental processes of modern life, being common in industrial refinery and hydrogen vehicles, all the way to the living cell. The dissociation of H2 on Cu(111) is an important benchmark system for studying heterogeneous catalysis, with a large and varied amount…

This thesis aims to improve the detection from ultra-weak single emitter by enhancing their emission properties with plasmonic nanostructures. We exploit the wet-chemically synthesized single crystalline gold nanorods (GNRs) as our basic frameworks in the whole studies, simply because of their unique…

Promotor: D. Bouwmeester, Co-promotor: D. Kraft

Metals surfaces form a group of effective catalysts for the reaction of small molecules such as hydrogen (H2).

Veel belangrijke onderwerpen in de informatica, zoals de juistheid van software, de efficiëntie van algoritmen en de modellering van gecompliceerde systemen, zijn afhankelijk van een goede theoretische onderbouwing. In de Theoriegroep bestuderen we deze fundamentele bouwstenen en ontwikkelen we verificatiemethoden…

In the thesis we demonstrated an 85% state transfer efficiency between two mechanical modes coupled to a common optical mode via stimulated Raman adiabatic passage (STIRAP) in the classical regime. We also showed possibilities to manipulate quantum states of the mechanical modes via STIRAP.

De biomedische wetenschap heeft een steeds grotere behoefte aan beeldmateriaal van biologisch materiaal op het niveau van cellen en eiwitten. Tjerk Oosterkamp, hoogleraar Experimentele natuurkunde, is gespecialiseerd in het ontwikkelen en gebruiken van tastmicroscopen om biologisch materiaal te bestuderen.…

De quantumfysica ontstond ongeveer 100 jaar geleden in Europa en bracht een ware technologische revolutie teweeg door middel van halfgeleiders, lasers, glasvezel en vele andere technologieën die vandaag de dag alomtegenwoordig zijn in ons leven. Nu, tijdens de tweede quantumrevolutie, kan Europa opnieuw…

De organisatie voor Economische Samenwerking en Ontwikkeling (OESO) heeft in samenwerking met het Inter-American Center of Tax Administrations (CIAT) op 27 november 2023 een wereldwijde online Tax Morale Workshop georganiseerd, waar Esther Huiskers-Stoop van de Universiteit Leiden en Diego Quiñones…

Somatische symptomen, zoals pijn, jeuk en vermoeidheid, blijken in twee richtingen samen te hangen met psychische symptomen. Hoewel acute somatische symptomen bepaalde adaptieve eigenschappen hebben, kunnen chronische symptomen in plaats daarvan leiden tot verstoring van dagelijkse activiteiten en vermindering…

De programmagroep verzorgt onderwijs op het gebied van diagnostiek, behandeling/preventie/interventie, neuropsychologisch onderzoek, gedragsobservaties, klinische vaardigheden, gesprekstechnieken, ondersteuning van leerkrachten en ouders, kennis over verstandelijke beperkingen en ontwikkelingsstoornissen…

This dissertation is an experimental study of laser-generated, atmospheric pressure, transient toroidal helium plasmas.

Even though more than 4000 extra-solar planets are known today, only a small fraction of these has been captured in an image. To better understand the planet formation mechanisms in solar-like environments we started the Young Suns Exoplanet Survey (YSES).

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

The study of orchid flowers, fruits, and inflorescences is crucial due to the remarkable diversity of orchid species and their unique adaptations to pollinators and seed dispersers. However, our understanding of the evolution and development of these organs within the orchid family remains limited.

Promotores: Prof.dr. B.R. Katzy, Prof.dr. K. Sailer (Munich University)

The electrochemical oxygen reduction reaction (ORR) is an essential half-reaction for the utilization of hydrogen as a sustainable fuel, via the conversion of hydrogen to electrons and protons facilitated by the ORR. In the most common fuel cells, the ORR is requires high loadings of non-abundant platinum…

The focus throughout this thesis will be on gathering fundamental studies of the detailed structure and composition of the electrode/electrolyte interface effect on the rate and mechanism of key electrocatalytic reactions.

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

The research aims to explore the evolutionary adaptability of enzymes and the impact of temperature on protein evolution pathways, using M. tuberculosis β-lactamase BlaC as the object of study. Enzymes inherently embody a delicate balance between activity and stability, and the acquisition of new enzymatic…

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

In a typical glycosylation reaction, a donor is activated to form a (variety of) electrophilic species which can react with a nucleophilic acceptor, following a reaction mechanism having both SN1 and SN2 character.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

Promotor: Roeland M.H. Merks

The research presented in this thesis makes use of small molecules (as H2 , D2 and O2 ) on well-defined single crystal surfaces (flat Pt(111), flat Cu(211) and curved Pt(111)) to elucidate the role of surface structure and degrees of freedom in the reactant in specific surface reactions.

Novel entities may pose risks to humans and the environment. The small particle size and relatively large surface area of micro- and nanoparticles (MNPs) make them capable of adsorbing other novel entities, leading to the formation of aggregated contamination.

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

Solar energy harnessed by plants and algae has great potential to be converted into biofuels for future generations.

Promotor: G.J. Kramer Co-Promotor: E.G.M. Kleijn

Promotor: V. Vitelli, Co-promotor: J. Paulose

Reducing greenhouse gas emissions is one of the most pressing challenges that humanity faces in the coming decades.

Ben jij nieuwsgierig naar hoe wetenschap en technologie bijdragen aan een duurzame en innovatieve toekomst? Bij de Universiteit Leiden onderzoek je de wereld van data, natuurwetten en levende systemen. Van wiskunde tot kunstmatige intelligentie, van klimaatvraagstukken tot hightech innovaties: je leert…

Computers worden steeds krachtiger en krijgen steeds ingewikkelder taken. Het Leiden Institute of Advanced Computer Science (LIACS) doet baanbrekend wetenschappelijk onderzoek en past nieuwe vindingen toe in actuele maatschappelijke vraagstukken.

Ben jij nieuwsgierig naar hoe wetenschap en technologie bijdragen aan een duurzame en innovatieve toekomst? Bij de Universiteit Leiden onderzoek je de wereld van data, natuurwetten en levende systemen. Van wiskunde tot kunstmatige intelligentie, van klimaatvraagstukken tot hightech innovaties: je leert…

Op deze pagina vind je een overzicht van prijzen en subsidies die in 2023 zijn toegekend aan onze medewerkers en studenten, en de bijzondere benoemingen aan de Universiteit Leiden en andere instellingen.

Transcutaneous vagus nerve stimulation (tVNS) was tested in chronic worriers. tVNS may reduce spontaneously occurring negative thought intrusions. After a worry induction, there was no longer an effect of tVNS. tVNS did not affect physiological responding to worrying.

The interest of this thesis lies in spin transport in normal metals and superconducting half-metallic junctions.

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

This thesis focuses on the development of sample-preparation methods for small amounts of samples and applying the developed methods to muscle tissues to investigate the mechanisms involved in sarcopenia.

Promotor: G.J.B. van Ommen

This course explores international arbitration as one of the most common methods of international dispute settlement. You will gain an in-depth understanding of international arbitration through the analysis of its role as a mechanism of dispute settlement, its institutions, the fields of law it is…

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

Welke rol spelen de leiderschapsstijl en de visie op leraren en leerlingen van schoolleiders in het bevorderen van een positief werkklimaat voor leraren en een positief leerklimaat voor leerlingen op scholen met een hoge schoolweging?

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.