822 zoekresultaten voor “sara cell differentiation” in de Publieke website
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Bioorthogonal Antigens as Tool for Investigation of Antigen Processing and Presentation
In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…
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In vivo modelling of Ewing sarcoma in zebrafish
Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska
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Accelerating the Photocatalytic Water Splitting in Catalyst−Dye Complexes
As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.
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Morphogenesis and protein production in Aspergillus niger
Promotores: C.A.M.J.J. van den Hondel, V. Meyer, Co-promotor: A.F.J. Ram
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Functional fluorescent materials and migration dynamics of neural progenitor cells
In this thesis, time-lapse fluorescent microscopy plays a pivotal role in investigating functional materials within living cells as well as the migratory behaviour of neural progenitor cells.
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Chemokine signaling mechanisms underlying inflammation and infection control: insights from the zebrafish model
This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.
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Towards artificial photosynthesis: resolving supramolecular packing of artificial antennae chromophores through a hybrid approach
Promotor: H.J.M. de Groot
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Eregalerij 2024
In 2024 hebben medewerkers en studenten van de Universiteit Leiden veel mooie prijzen gewonnen en belangrijke onderzoekssubsidies binnengehaald.
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Learning cell identities and (post)-transcriptional regulation using single- cell data
Promotie
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TCRs as Precision Tools against B-cell and Plasma Cell Malignancies
Promotie
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Sylvia Le DévédecWiskunde en Natuurwetenschappen
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Development of novel anti-cancer strategies utilizing the zebrafish xenograft model
In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…
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Nieuwjaarsreceptie Faculty of Science
Congres/symposium
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Exploring and exploiting CD8+ T cell proliferation
Promotie
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Click to Release for Immunce Cell Activation
Promotie
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How costimulation directs regulatory T cell responses
Promotie
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Single-cell immune profiling of atherosclerosis
Promotie
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Immune cell networks in Inflammatory Bowel Disease
Promotie
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The aging B cell landscape in atherosclerosis
Promotie
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Red cell transfusion in critically ill patients
Promotie
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Investigations on the role of impaired lysosomes of macrophages in disease
The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.
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The diverse roles of integrin α3β1 in cancer: Lessons learned from skin and breast carcinogenesis
In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.
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The role of autophagy during carbon starvation in Aspergillus niger
Autopaghy is an intracellular degradation system which targets cytosolic components to lytic compartments for degradation and recycling of the building blocks of the cell.
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Towards the development of synthetic vaccines against tuberculosis
The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.
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Design and Synthesis of Inhibitors and Probes for Sulfoquinovosidases and Xylanases
This thesis focuses on the design and synthesis of activity-based probes and inhibitors targeting enzymes involved in the degradation of specific plant glycans.
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Development of an in vitro vascular network using zebrafish embryonic cells
One of the major limitations in culturing complex tissues or organs is the lack of vascularization in the cultured tissue. Development of a functional capillary bed could overcome this problem.
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Squaramide-based interpenetrated networks for load-bearing applications
This thesis explores squaramide-based supramolecular polymers and hydrogels, enhancing their mechanical strength for 3D cell culture.
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Transforming data into knowledge for intelligent decision-making in early drug discovery
Promotor: A.P.IJzerman Co-promotor: A. Bender
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Copper complexes for bioinspired electrocatalysis relevant to the reduction of oxygen
This thesis advance our understanding and the application of molecular catalysts relevant to the reduction of oxygen as well as reduction of nitrite.
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Bioorthogonal Antigens
The aim of this thesis is to explore the use of Bioorthogonal Antigens to study the cross-presentation pathway.
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Spin-label EPR Approaches to Protein Interactions
Promotor: Prof.dr. E.J.J. Groenen, Co-Promotor: M. Huber
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Applications for DNA-encapsulated silver clusters in physics, biology and medicine
We use DNA strands to stabilize few-atom silver clusters, which show unique optical and chemical properties. This thesis involves the study of these constructs for various applications.
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Adjuvanted nanoparticulate seasonal influenza vaccines
Promotor: W. Jiskoot, Co-promotor: A. Kros
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Night Spaces: Migration, Culture and Integration in Europe (NITE)
Hoe worden nachtruimtes verbeeld, geproduceerd, ervaren en verteld door migrantengemeenschappen in Europa? Dit onderzoeksproject onderzoekt deze vraag in acht Europese steden: Aarhus, Amsterdam, Berlijn, Cork, Galway, Lissabon, Londen en Rotterdam.
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Student & Staff Stories
Maandelijks interviewen we een student of medewerker van de Universiteit Leiden over hun werk of studie in relatie tot duurzaamheid.
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Medewerkers
Bekijk hier de medewerkers van LUBEC Jeugd. Wilt u contact opnemen met een medewerker? Neem dan contact op met het LUBEC secretariaat ( 071-527 4063 of lubec@fsw.leidenuniv.nl).
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Politiek spelen: mediaplatforms, werelden maken
Dit project onderzoekt hoe spel en politiek elkaar beïnvloeden in een postdigitale samenleving, en welke nieuwe mogelijkheden voor samenwerking, strategie en betekenisvolle verbindingen socialemediaplatforms bieden.
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PhD Positions Mainz
Within the Research Training Group 2304 “Byzantium and the Euro-Mediterranean Cultures of War. Exchange, Differentiation and Reception”, which is financed by the DFG (German Research Foundation), there are at the Johannes Gutenberg University of Mainz 2 positions for doctoral research associates (pay…
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Postdoc position (Mainz)
Within the Research Training Group “Byzantium and the Euro-Mediterranean Cultures of War. Exchange, Differentiation and Reception” at the Johannes Gutenberg University of Mainz 1 postdoctoral position is to be filled by 1 April 2023, for a period of up to 4,5 years. Deadline: 5 January 2023.
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Integration and disentanglement of single-cell and spatial transcriptomics with applications in Autosomal Polycistic Kidney Disease
Promotie
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Hoe uitzaaiende tumoren hun omgeving naar hun hand zetten
Tumoren gedragen zich als mini-orgaantjes, manipuleren hun omgeving en gebruiken lichaamseigen processen om te overleven en uit te zaaien. Door onderzoek van Erik Danen en zijn collega’s komen we steeds meer te weten over de complexe aard van tumorcellen. In het NRC vertellen de wetenschappers over…
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Diesfestival voor alumni
Het Leids Universiteits Fonds viert 450 jaar Universiteit Leiden en dat pakken we groots aan!
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Afrika
Aan het LUCL bekijken we bijna alle aspecten van een grote hoeveelheid Afrikaanse talen. Van fonologie tot antropologische taalkunde, van theoretische syntaxis tot straattaal: we onderzoeken het allemaal.
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Regiokennis van Zuid-Amerika
Leidse experts van Zuid-Amerika hebben specialismes zoals talen, culturen, antropologie, archeologie, geschiedenis, filosofie en genetica. Samen proberen zij de mysteries en het verborgen verleden van het Amerikaanse continent te ontdekken.
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Applications of multisource data-based dynamic modeling to cell-cell signaling and infectious disease spreading
Promotie
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Donor T-cell responses and interaction with graft versus host target tissue after allogeneic stem cell transplantation
Promotie
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Ahmed Mahfouz: 'Het mysterie van hersenziekten, cel voor cel uitgezocht'
Welke hersencel doet wát als bijvoorbeeld de ziekte van Parkinson ontstaat? Het duurt niet lang meer voordat die puzzel stukje voor stukje gelegd kan worden. Computationeel bioloog Ahmed Mahfouz combineert Leidse bio-kennis met Delftse algoritmen en komt steeds dichterbij de sleutel.
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Getting personal: Advancing personalized oncology through computational analysis of membrane proteins
Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.
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Toll-like receptor signaling in the innate immune system of zebrafish larvae
Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez
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Discovery and exploitation of the transcriptional regulatory system of pectinases in Aspergillus niger
Pectin is a plant cell wall polysaccharide made of mainly D-galacturonic acid (GA) subunits. The potency of the filamentous fungus Aspergillus niger to naturally secrete high amounts of pectinases to degrade pectin has been utilized for the industrial production of pectinases.