1,573 zoekresultaten voor “3d modelling” in de Publieke website
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Mirko ForastiereFaculteit der Wiskunde en Natuurwetenschappen
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Amie CorbinFaculteit der Wiskunde en Natuurwetenschappen
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The potential of multi-scale EE-MRIO to support sustainable development policies in Indonesia
Global Environmental Extensions Multi-Regional Input-Output (EE-MRIO) analysis is often used to analyze how changes in global and national demand for products lead to socioeconomic and environmental impacts at the national level.
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Liposome-based synthetic long peptide vaccines for cancer immunotherapy
Promotores: Wim Jiskoot; Ferry Ossendorp
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Opinion Dynamics on Random Graphs
This thesis investigates opinion dynamics on random graphs through the lens of the voter model, a classical interacting particle system used to describe how consensus emerges in networks.
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Pulling the strings on anti-cancer immunity
Promotores: J. Jonkers, K.E. de Visser
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Stress-induced protein dynamic and growth arrest in C. elegans during development
During post-embryonic development into adults, animals face an environment that fluctuates constantly. For example, in nutrient availability, temperature, and osmolarity (e.g., salt concentration).
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On transport properties of Majorana fermions in superconductors: free & interacting
Majorana fermions in superconductors are the subgap quasiparticle excitations that are their own antiparticles.
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Lipid mediated colloidal interactions
The lipid membrane is a basic structural component of all living cells. Embedded in this nanometer-thin barrier, membrane proteins shape the membrane and at the same time respond to the shape of the membrane.
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When data compression and statistics disagree: two frequentist challenges for the minimum description length principle
Promotor: P.D. Grünwald
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Structural Health Monitoring Meets Data Mining
Promotor: Prof.dr. J.N. Kok, Co-promotor: A.J. Knobbe
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Ruthenium-peptide conjugates for targeted phototherapy
As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.
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Concepts and applications for evidence-based dosing in morbidly obese patients before and after weight loss surgery
Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst
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Yu-Hsuan Huang -
Uniform infinite and Gibbs causal triangulations
Promotor: Richard D. Gill
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Individualization of Drug Clearance Predictions and Dose Regimens in Patients with Obesity Using Pharmacometric Approaches
This thesis aims to develop model-based approaches to optimize drug dosing in patients with overweight and (morbid) obesity.
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Project SkinPrint van Leidse masterstudenten wint de Digital Award van de Philips Innovation Award
Vier Leidse studenten die de masterspecialisatie Science Based Business volgen, bedachten een concept om met een 3D Bioprinter menselijke huid te produceren. Slachtoffers van brandwonden zouden dankzij Skinprint minder operaties nodig hebben en er minder littekens aan over houden.
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Monitoring Alzheimer's disease in transgenic mice with ultra high field magnetic resonance imaging
Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia
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Evolution and development of flowers, fruits and inflorescences of Phalaenopsis and other orchid species
The study of orchid flowers, fruits, and inflorescences is crucial due to the remarkable diversity of orchid species and their unique adaptations to pollinators and seed dispersers. However, our understanding of the evolution and development of these organs within the orchid family remains limited.
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RNA splicing in breast cancer progression
In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.
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Design and application of dextran based cross-linked networks
This thesis describes the design, characterization and application of dextran based crosslinked network.
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Quantitative Super-Resolution Microscopy
Promotor: T. Schmidt
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Fluorescence Correlation Spectroscopy on Electron Transfer Reaction: Probing Inter- and Intramolecular Redox Processes
Promotores: G.W. Canters, T.J. Aartsma
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Forever Young: How AHL15 delays developmental phase transitions to prevent ageing in plants
The AT-Hook Nuclear Localized 15 (AHL15) gene belongs to a plant-specific gene family of DNA-binding proteins. Overexpression of AHL15 in Arabidopsis thaliana delays developmental phase transitions whereas its loss of function causes a slight acceleration.
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Real-time tomographic reconstruction
With tomography it is possible to reconstruct the interior of an object without destroying.
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High throughput microscopy of mechanism-based reporters in druginduced liver injury
Promotor: B. van de Water
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Molecules during stellar formation and death
Promotor: Prof.dr. E. F. van Dishoeck
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Spectral imaging and tomographic reconstruction methods for industrial applications
Radiography is an important technique to inspect objects, with applications in airports and hospitals. X-ray imaging is also essential in industry, for instance in food safety checks for the presence of foreign objects.
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Novel detectors and algorithms for electron nano-crystallography
Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel
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Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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Invariant manifolds and applications for functional differential equations of mixed type
Promotor: S.M. Verduyn Lunel
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Challenges in survival analysis: sequential analysis, prediction and non- parametric estimation
Overlevingsanalyse is een onderzoeksgebied dat zich richt op het bestuderen van de tijd tot het optreden van een specifieke uitkomst.
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Franz WurmFaculteit der Sociale Wetenschappen
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Hai LinFaculteit der Wiskunde en Natuurwetenschappen
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Xiaoyang ZhongFaculteit der Wiskunde en Natuurwetenschappen
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Stefano MerciaiFaculteit der Wiskunde en Natuurwetenschappen
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Tycho JongenelenFaculteit der Wiskunde en Natuurwetenschappen
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Dual Complexes of Semistable Varieties
This thesis is comprised of three chapters covering the theme of studying semistable varieties by looking at their dual combinatorial objects.
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Emergence of Linguistic Universals in Neural Agents via Artificial Language Learning and Communication
Human language is constantly evolving with its linguistic structure being shaped by language users at both individual and population levels. Focusing on the interplay between processes of language acquisition and communicative need in shaping human languages, this thesis introduces a novel computational…
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Geert-Jan WillFaculteit der Sociale Wetenschappen
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Archeologen reconstrueren bouwlust oude Grieken
In Mykeens Griekenland verschenen vanaf 1600 v. Chr. zeer veel monumentale bouwwerken zoals grote graftombes. Waarom stopte die bouwlust 400 jaar later abrupt? Archeoloog Ann Brysbaert onderzoekt de mogelijke oorzaken dankzij haar ERC Consolidator Grant.
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Imag(in)e the human male gonad in 3D
Promotie
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The Use of 3D Skin Equivalents Mimicking Skin Cancers
Promotie
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Lipidomics study in liver metabolic diseases
The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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Role of integrin adhesions in cellular mechanotransduction
Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen
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Dynamic hydrogels as synthetic extracellular matrices for three- dimensional cell culture
Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.
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Photothermal circular dichroism studies of single nanoparticles
In this work, we investigate the minute circular dichroism effects of single nanoparticles.To this aim, we apply photothermal imaging with a polarization-modulated heating beam.
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Systematic investigations into the role of ceramide subclass composition on lipid organization and skin barrier
The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.
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Interactive scalable condensation of reverse engineered UML class diagrams for software comprehension
Promotores: Prof.dr. J.N. Kok, Prof.dr. M.R.V. Chaudron (Chalmers Univ., Sweden)