Een lijst met wetenschappelijke publicaties samengesteld door het team van het TRIXY Expertisecentrum.

Een chemokuur die niets doet, totdat je hem met licht bestraalt. Voor de ontwikkeling daarvan ontving Sylvestre Bonnet een Vici-beurs van 1,5 miljoen euro. Hiermee 'bouwt' de Leidse chemicus een nieuw molecuul om tumoren te bestrijden die nu nog lastig te behandelen zijn.

Het Leids Studiesysteem biedt goede begeleiding bij je studiekeuze én tijdens je studie. Samen maken we van jouw studie een succes.

Promotor: G.P. van Wezel

DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.

This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…

The plant hormone auxin regulates plant growth and development through polar cell-to-cell transport-generated maxima and minima. PIN FORMED (PIN) auxin efflux carriers determine the direction of this auxin flow through their asymmetric placement on the plasma membrane (PM).

Leerlingen uit de bovenbouw van het vwo binden de strijd met elkaar aan op het Max Havelaar Toesprakentoernooi. Het doel: een topspeecher worden, je verdiepen in fairtrade én het werk van Multatuli beter leren kennen.

In the last decade, the redox interconversion between metal thiolate and disulfide compounds has been extensively investigated for copper, but not for other transition metal ions.

Promotores: Prof.dr. G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij

De universitaire Visie op Studentenwelzijn geeft richting aan de manier waarop de universiteit het welzijn van haar studenten de komende jaren wil bevorderen.

This thesis focuses on enhancing predictions of central nervous system drug exposure using the LeiCNS-PK3.0, a physiologically based pharmacokinetic model.

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

Despite the history of studies on methanol formation from CO2, the dominant elementary reaction steps that constitute the chemical mechanism for this catalyzed process are not determined.

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…

Promotor: M. Danhof Co-promotor: O.E. Della Pasqua

Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.

There is concern about the threat that nanoplastics (NPs) may pose to both wildlife and humans. This thesis explores the mechanisms of toxicity of polystyrene nanoparticles (PS-NPs) in chicken embryo.

The aim of the research presented in this thesis was to develop new methods forchallenging systems in liquid-state NMR using paramagnetic effects generated by thetwo-armed probe CLaNP-5.

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

The thesis describes the use of electron paramagnetic resonance (EPR) spectroscopy, in continuous wave and pulse modes, to address the interaction of α-Synuclein (αS) with membranes and the aggregation of αS.

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.

Promotie

Tessa van Schagen en Naomi Sedney weten hun studie Psychologie en topsport goed te combineren. Beide studenten lopen op de Olympische Spelen de estafette 4x100 meter. Van Schagen: 'Andere studenten vinden het ook wel leuk dat ik naar Rio ga.'

In dit interdisciplinaire onderzoeksprogramma werken onderzoekers uit vijf verschillende disciplines met elkaar samen. Zij stellen zich hieronder (in het Engels) aan u voor.

Promotor: G.A. Persoon, Co-promotor: H.H. de Iongh

This thesis presents the results of a study on the interfaces of insulating oxides with and without the insertion of a magnetic layer.

Atoms and molecules are the basic units of matter. If we keep dividing a bar of gold or a glass of water into smaller parts, at the end we are left with a single gold atom or a water molecule.

In een levendige schets van de recente geschiedenis van islam en moslims in Nederland laat Maurits Berger zien hoe dat zo is gekomen. Hij toont aan dat we die geschiedenis in eigen hand hebben, en kunnen wijzigen als we willen.

Decentralized plug and play systems for energy production are the future picture of our society. Artificial photosynthetic systems are used for this purpose.

This research delves into a region of space known as the interstellar medium (ISM), which is essentially the area between the stars filled with gas and dust.

This dissertation is an experimental study of laser-generated, atmospheric pressure, transient toroidal helium plasmas.

The theoretical explanation of cosmic acceleration is nowadays one of the biggest puzzles in cosmology.

The study of orchid flowers, fruits, and inflorescences is crucial due to the remarkable diversity of orchid species and their unique adaptations to pollinators and seed dispersers. However, our understanding of the evolution and development of these organs within the orchid family remains limited.

Promotores: Prof.dr. J.N. Kok, Prof.dr. M.R.V. Chaudron (Chalmers Univ., Sweden)

Promotor: Carel J. ten Cate, Co-Promotor: Hans W. Slabbekoorn

In times of hardships or crisis, local people know how to deal with it using their resourcefulness. Although efforts are sometimes made by the government to help them, they are fully aware that community support is at least equally important.

Heterogeneous catalysis is essential to many industrial applications. These catalysts are often comprised of supported nanoparticles, which contain various different surface sites.

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

Bacteria have the ability to alter their morphology in order to adapt to changing environments.

Mechanical metamaterials are carefully engineered materials whose properties are controlled by their structure, not by their composition, which allows using metamaterials to study and control physical effects in detail⁠.

The focus of the dissertation

Op 28 oktober 2021 verdedigde Hein van der Bruggen zijn proefschrift en behaalde daarmee de doctorstitel.

Promotor: Prof. dr. Arnold Tukker & Prof. dr. René Kemp (Maastricht University)

In this thesis, we present new laboratory data of interstellar dust analogues.

Global Environmental Extensions Multi-Regional Input-Output (EE-MRIO) analysis is often used to analyze how changes in global and national demand for products lead to socioeconomic and environmental impacts at the national level.

Promotor: S.M. Verduyn Lunel, Co-promotoren: M.F.E. de Jeu, S.D. Silvestrov