This work describes several studies into the electroreduction of carbon dioxide (CO2RR), both regarding mechanistical aspects and catalyst stability considerations. Mechanistic insights into carbon-carbon bond formation on a silver catalyst are described in Ch 2, were we find an acetaldehyde-like surface…

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

Mycoheterotrophy is a particular mode of life in which plants obtain carbohydrates from their associated fungal partners, instead of by using photosynthesis.

Despite the history of studies on methanol formation from CO2, the dominant elementary reaction steps that constitute the chemical mechanism for this catalyzed process are not determined.

The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

Humanity stands at a pivotal juncture, facing the dual challenge of environmental sustainability and rapid population growth, projected to exceed 11 billion by century’s end.

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

Bicarbonate buffer is largely found in nature due to its ability to regulate pH variations around neutral values. As the pH changes, so does the speciation of the buffer.

The increasing resistance of pathogenic bacteria to antibiotics necessitates the discovery of new medicines.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

In this thesis, the role of plant-mediated soil legacy effects in shaping aboveground plant-insect interactions was investigated.

Inspired by natural photosynthesis, perovskite-based photoelectrochemical (PEC) systems are being developed for artificial photosynthesis, aiming to enhance solar-to-hydrogen conversion for green energy.

For centuries astronomers studied the Universe by collecting light. Nowadays, we are living in times of great technological advancements, which allow us to explore our Universe in a new way - though gravitational wave radiation.

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

Promotores: W. Th. F. den Hollander, M.O. Heydenreich

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

Self-assembly is an abundant process in nature and is vital to many processes in living organisms.

All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).

Electrocatalysis allows for storing electricity or converting it into chemical bonds, producing chemical building blocks and fuels using renewable resources.

G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.

Stars and planets form within cold, dense clouds of gas and dust drifting through interstellar space. Although dust makes up only a small fraction of this material, it plays a key role in shaping the chemical evolution of these environments.

Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk

Promotor: Prof.dr. M. Ubbink

This thesis is concerned with the constitution of chiral responsive matrix assemblies that may undergo light-driven conformational changes and self-select vibrations to develop vibronic states for driving semi-classical coherent transfer with nearly 100% yield in a lossless NCAP process.

The aim of the research presented in this thesis was to develop new methods forchallenging systems in liquid-state NMR using paramagnetic effects generated by thetwo-armed probe CLaNP-5.

Hydrodesulfurization (HDS) is an ubiquitous part of oil refining that ensures that fuels are cleaned of impurities and environment release of pollutants such as SOx and NOx gasses are minimized.

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

Promotor: Prof.dr. E. F. van Dishoeck

Promotor: D. Bouwmeester, Co-promotor: D. Kraft

Promotor: M.T.M. Koper, Co-promotor: J.B.F. Juurlink

Promotor: Prof.dr. J.P. Abrahams, Co-Promotor: N.S. Pannu

Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.

Heterogeneous catalysis is one of the fundamental processes of modern life, being common in industrial refinery and hydrogen vehicles, all the way to the living cell. The dissociation of H2 on Cu(111) is an important benchmark system for studying heterogeneous catalysis, with a large and varied amount…

Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.

Metals surfaces form a group of effective catalysts for the reaction of small molecules such as hydrogen (H2).

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

Studievoorlichting

Promotor: E. F. van Dishoeck, Co-promotor: C. Walsh

Studievoorlichting

This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

Burgemeesters hebben te maken met een samenleving die polariseert, een politiek die steeds en sneller wisselt en een gefragmenteerd bestuurlijk krachtenveld. Aan burgemeesters worden steeds meer verschillende en ook steeds vaker tegenstrijdige eisen gesteld. Wat betekent het om burgemeester te zijn…

Kersverse hoogleraar Gerard van Westen werkt op het snijvlak van kunstmatige intelligentie en medicijnontwikkeling. Voor de nieuwe leerstoel Artificial Intelligence and Medicinal Chemistry zet hij computermodellen in om medicijnontwikkeling efficiënter te maken. ‘ Ons ultieme doel is een virtuele mens…

Promotie

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

Als gevolg van de grote technologische vooruitgang in de gezondheidszorg worden in toenemende mate gegevens verzameld tijdens de uitvoering van klinische onderzoeken.