Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

The aim of this thesis is to study cell-cell interactions and the development of an assay to explore and quantify the exchange of membrane compounds.

The transition to electric vehicles (EVs) reduces vehicle emissions to combat climate change. EVs raise concerns regarding the production of lithium-ion batteries and related emissions; while batteries can also provide energy storage services for the electricity system.

Thirty years ago, mutations in the BRCA1 gene were first linked to hereditary breast and ovarian cancer, establishing a genetic basis for cancer development.

Promotor: C.J. ten Cate, Co-promotor: H.W. Slabbekoorn

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

Onderzoeken hoe gegevens afkomstig van draagbare technologieën kunnen worden gebruikt om effectieve gedragsveranderingen te identificeren die hopelijk zullen leiden tot gezondheidsverbeteringen.

Op donderdag 15 december is Elisavet Alexiadou gepromoveerd op haar proefschrift: ‘The Right to Health. A Human Rights Perspective with a Case Study on Greece'. Promotor was hoogleraar gezondheidsrecht Aart Hendriks.

Athletes always strive for the top. How can data scientists assist them in improving their performance? During the seminar Data Science and Sports, the possibilities and challenges of collaboration between these two worlds were discussed.

This thesis seeks to investigate how cancer-associated mutations affect the pharmacological properties of selected GPCRs—primarily A2AAR and 5-HT2CR—through a combination of ligand binding assays, signaling readouts, kinetic profiling, and cellular functional assays.

Following the Big Bang, structure in the Universe started collapsing under the force of gravity. This resulted in the formation of the first stars, galaxies and clusters of galaxies.

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

Vanaf de koloniale tijd tot heden hebben grote aantallen Javanen hun woonplaats verlaten om zich in andere delen van Indonesië of veel verder weg te vestigen. Vaak was deze spreiding gedwongen, vaak met traumatische gevolgen.

Electoral Systems and Turnout: Evidence From a Regression Discontinuity Design. In dit artikel, gepubliceerd op de website SAGE research methods, bespreken auteurs Jaroslaw Kantorowicz en Tobias M. Hlobil hoe een Regression Discontinuity Design uitgevoerd kan worden.

This Thesis describes the synthesis of D-alanylated ribitol-based wall teichoic acids from S. aureus to probe their interaction with immune-binding partners.

This dissertation presents new cryptographic protocols, which can be divided into two families.

Promotor: H.J.A. Röttgering, Co-promotor: M. Haverkorn

This thesis presents insights from our study of various correlated electron systems with a scanning tunneling microscope (STM). In ordinary metals, electron-electron interactions exist, but get substantially screened due to the sheer number of electrons.

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…

Promotor: Prof.dr. J.N. Kok

Tuberculosis (TB) is associated with 1.5 million deaths annually. There is a need exists to optimize both current as well as novel antibiotic combination treatment strategies to improve the effectiveness and safety of treatments against TB.

This thesis aims to enhance our understanding of galaxies by testing theoretical models of galaxy formation against observations, particularly in the cases of extreme systems which have been found to have an excess of baryonic mass in their central regions, in the form of either supermassive black holes…

In dit artikel onderzoeken de onderzoekers hoe solidariteit begrepen kan worden, rekening houdend met de diversiteit van verhalen, ruimtes, praktijken, lichamen en tijdsperiodes in een stad.

Op 14 december 2016 verzorgde Steven L. Schwarcz, Stanley A. Star Professor of Law & Business aan Duke University School of Law de dertiende Hazelhoff Guest Lecture. Voorafgaand aan deze lezing organiseerde het Hazelhoff Centre for Financial Law een rondetafelgesprek met Professor Schwarcz en personen…

Promotor: Prof.dr. B.R. Katzy

Wessel Kraaij is per 1 maart 2016 benoemd als hoogleraar ‘Applied Data Analytics’. Kraaij gaat grote datasets analyseren met nieuwe methoden. Met data van partijen uit verschillende data-intensieve onderzoeksdomeinen wil hij de methoden ook toetsen in de praktijk.

This thesis provides an overview of the development of the Pair Configuration to Molecular Activity Coefficient (PAC-MAC) model.

Promotor: Prof.dr. M.T.M. Koper, Co-Promotor: F. Calle-Vallejo

This thesis covers various applications of topology in condensed matter physics and quantum information.

How can data analytics be used as a research method in the field of legal research? This question was addressed during the Research Lab Legal Data Science on 23 September, 2016.

This thesis revolves around the electronic spectroscopy of molecules in the laboratory and the search for the carriers of the diffuse interstellar bands (DIBs).

The physical origin of the dozens of stellar-mass binaries, the mergers of which have been detected by the LIGO-Virgo-KAGRA collaboration via gravitational waves, is still unknown.

On dinsdag 26 september heeft Jessica Hill haar proefschrift ‘On the road to adulthood. Delinquency and desistance in Dutch emerging adults’ verdedigd. Promotor is Professor Arjan Blokland.

Sport Data Center

Promotor: A.P.IJzerman Co-promotor: A. Bender

Op 21 november 2018 verdedigde Lieke Kools haar proefschrift 'Essays on wealth, health, and data collection'. Het promotieonderzoek is begeleid door promotoren prof. dr. K.P. Goudswaard en prof. dr. C.L.J. Caminada.

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Nederland wint al jaren de meeste medailles bij schaatsen op de Olympische Spelen. Hoe ze dat doen? Op gevoel. Bewegingswetenschapper Jeroen van der Eb van de Data Mining & Sports groep van het Leiden Institute of Advanced Computer Science (LIACS) wil dat schaatsers hun schaatsen afstellen op basis…

Op 20 februari 2019 vond een bijzondere bijeenkomst over data science plaats in de Tweede Kamer. De doelstelling van de bijeenkomst was om met overheidsorganisaties in dialoog te gaan over dataontwikkelingen binnen de overheid.

Hoewel veel beroepsbeoefenaren in de gezondheidszorg aangeven vaak gebruik te maken van placebo-effecten en de mechanismen ervan, is er weinig formele training over hoe om te gaan met placebo- en nocebo-effecten in de klinische praktijk. Dit project wil deze kloof tussen wetenschappelijke kennis over…

In bijna elk wetenschappelijk vakgebied wordt gebruik gemaakt van data science. Dat biedt vele nieuwe mogelijkheden, maar ook nieuwe dilemma’s. Daarom vindt op 5 maart het symposium ‘Fairness and Transparency, towards responsible data science’ plaats. Hoofdspreker Ricardo Baeza-Yates licht een tipje…

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

There is accumulating evidence for an increase in severe global drought events. In particular, Europe experienced several severe droughts in 2003, 2015, and 2018 (unprecedented in the past 2,110 years). Such droughts have caused serious and far-reaching impacts on terrestrial ecosystems.

Neurodegenerative diseases pose a large medical and societal challenge. The etiology of these diseases is still poorly understood, which makes drug discovery for these diseases difficult.

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken