Promotores: H. Schiessel, G.T. Barkema

Cardiovascular diseases (CVDs) are the leading global cause of mortality. Endothelial dysfunction, an early reversible stage of CVD development, is marked by decreased nitric oxide production linked to Ca2+ influx in endothelial cells.

Traditional hypothesis testing requires researchers to set a fixed sample size in advance. After collecting data, the test determines whether to reject the null hypothesis.

Single-Molecule Microscopy (SMM) techniques constitute a group of powerful imaging tools that enable researchers to study the dynamic behavior of individual molecules.

This thesis investigates the structural evolution and assembly of galaxies since the first few billions years after the big bang.

‘Legitimacy and Justice’ is een onderzoekscluster binnen het programma ‘Institutions, Decisions and Collective Behaviour’. De wetenschappers die hierin actief zijn houden zich bezig met de legitimiteit en rechtvaardigheid van politieke instituties. Zij kijken in het bijzonder naar de relaties tussen…

How are new drugs developed? This question is central to the Minor Modern Drug Discovery (MDD), which covers the entire trajectory from disease to drug molecule and vice versa. The various research groups involved offer a complementary and interdisciplinary perspective by connecting the diverse subjects…

Hot rocky exoplanets are planets that orbit so close to their host star that they possess a molten surface.

Het seminar op 30 november jl. over schijnconstructies en intra EU arbeidsmigranten trok veel belangstellenden en was een succes. Deze bijeenkomst werd georganiseerd vanuit het onderzoeksproject Solidarity under Strain (SOLID), onderdeel van de Research Focus Area 'Interaction between Legal Systems…

Promotor: G.J. Kramer Co-Promotor: E.G.M. Kleijn

Human language is constantly evolving with its linguistic structure being shaped by language users at both individual and population levels. Focusing on the interplay between processes of language acquisition and communicative need in shaping human languages, this thesis introduces a novel computational…

Twaalf Leidse onderzoekers ontvangen restgelden in het kader van ILS 2.0. Met dit onderzoeksgeld kunnen zij zich richten op het voorbereiden van subsidievoorstellen en het ontwikkelen van nieuwe onderzoekslijnen.

In our research protein translocation from Agrobacterium into yeast and plant cells is studied to obtain fundamental insights in the translocation process

Het profileringsgebied Interaction between Legal Systems is multidisciplinair en stimuleert innovatief onderzoek met een inhoudelijke focus op de interactie tussen rechtsstelsels. Voor de komende onderzoeksperiode 2016-2020 zijn uit alle inzendingen drie winnende projecten geselecteerd.

This study attempts to understand how indigenous community institutions pose an important role in sustainable community-based development, including the integration between local culture and development.

Promotor: W. T. F. den Hollander, F. H. J. Redig

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

Promotor: Prof.dr. J.N. Kok, Co-promotor: A.J. Knobbe

This dissertation investigates the energy and material related impacts of the transition towards a low-carbon heating system in the Netherlands, in the context of its 2050 climate and circular economy policy goals.

Stars like the sun are born in large molecular clouds existing from gas and dust. During the formation process, the chemical composition of the material can be altered drastically by the changing physical conditions.

This thesis explores how electron paramagnetic resonance (EPR) spectroscopy can be used to investigate key biochemical processes.

Time-series forecasting through modelling sequences of temporally dependent observations has many industrial and scientific applications. While machine learning models have been widely used to create time-series forecasting models, creating efficient and performant time-series forecasting models is…

Studying the impact of urbanisation on the respiratory health of past Dutch populations (1200-1850 CE).

Promotor: W. Jiskoot, Co-promotor: A. Kros

Dit was het programma van De Kennisboomgaard 2025:

We have examined sequences from the ligand-binding domain of the nicotinic acetyl choline receptor (nAChR) in 148 vertebrate species. We are in interested in this receptor because the α-neurotoxins of many venomous snakes binds to this receptor in its location at the neuromuscular junction in all ve…

The ultimate aim of this project is to improve cooperation between courts in different Member States.

Lezing

Op 21 september gaf Magdalena Jozwiak, onderzoeker bij eLaw - Centrum voor Recht en Digitale Technologie, een presentatie over het e-SIDES project tijdens een ILS Lunch Seminar.

In this thesis, we examine various systems through the lens of several numerical methods.

This thesis has described novel synthetic methods to produce a variety of (glyco)peptides and their application in the study of various immunological processes.

This thesis provides an overview of the development of the Pair Configuration to Molecular Activity Coefficient (PAC-MAC) model.

Dissochaeta Blume (Melastomataceae, tribe Dissochaeteae) is well-known as a scrambling plant genus found in Southeast Asia, where it is an inhabitant of the tropical rainforests or evergreen forests.

Promotor: G.R. de Snoo Co-promotor: C.J.M. Musters

In this thesis new methodologies are developed for the detection and systematic study of radio sources in the early universe. This allows us to gain a deeper understanding of the formation and evolution of galaxies, the activity of supermassive black holes, and the final phase transition of our universe:…

The primary goal of this research is to deepen our understanding of substrate-enzyme interactions in Glycoside hydrolases. For this purpose, Bacillus circulans xylanase (BcX) has been selected as a well-established model to examine the Michaelis complex and glycosyl-enzyme adduct.

Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: G.J. Herczeg

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

In this thesis, we address two problems concerning the tautological rings of the moduli space of curves.

Promotores: F.H.J. Redig, W.T.F. den Hollander

The global agri-food system plays a critical role in food security and environmental issues.

Promotores: G.A. Persoon, H.H. de Iongh

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

Artificial photosynthesis has recognised potential to produce green and sustainable fuels from earth-abundant resources such as water, carbon dioxide (CO2), and sunlight.

Op vrijdag 24 maart gaf prof: Amanda Perry-Kessaris (Kent Law School) een korte workshop over data visualisation voor de promovendi van de afdeling Economie. Tijdens deze workshop werden de promovendi uitgedaagd om door middel van LEGO hun onderzoek te visualiseren. Amanda Perry-Kessaris gaf daarna…

Op vrijdag 24 februari zal Prof. Judith Masson (Bristol University), Hoogleraar Rechtssociologie en Fellow bij the UK Academy of Social Science, een lezing geven binnen de Leiden Socio-Legal Series.

In het kader van ILS 2.0 zijn er restgelden beschikbaar voor het indienen van subsidievoorstellen en - direct daaraan gekoppeld en inherent daaraan - het ontwikkelen van nieuwe onderzoekslijnen. Per aanvraag geldt een maximumbudget van 40.000 euro. In totaal is 180.000 euro beschikbaar voor deze cal…

Quantummechanica voor iedereen