The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

Promotor: Prof.dr. E. F. van Dishoeck

Promotor: D. Bouwmeester, Co-promotor: D. Kraft

Promotor: M.T.M. Koper, Co-promotor: J.B.F. Juurlink

Promotor: Prof.dr. J.P. Abrahams, Co-Promotor: N.S. Pannu

Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.

Heterogeneous catalysis is one of the fundamental processes of modern life, being common in industrial refinery and hydrogen vehicles, all the way to the living cell. The dissociation of H2 on Cu(111) is an important benchmark system for studying heterogeneous catalysis, with a large and varied amount…

Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.

Metals surfaces form a group of effective catalysts for the reaction of small molecules such as hydrogen (H2).

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

Promotor: E. F. van Dishoeck, Co-promotor: C. Walsh

Studievoorlichting

This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

Over the last three decades, the discovery of exoplanets has revealed the boundless variety of worlds beyond our own Solar System⁠. Majority of planetary systems contain short-period planets that are larger than Earth but smaller than Neptune⁠.

Kersverse hoogleraar Gerard van Westen werkt op het snijvlak van kunstmatige intelligentie en medicijnontwikkeling. Voor de nieuwe leerstoel Artificial Intelligence and Medicinal Chemistry zet hij computermodellen in om medicijnontwikkeling efficiënter te maken. ‘ Ons ultieme doel is een virtuele mens…

On 28 September, the Medieval Murder Maps website will be shared publicly for the first time. The makers have used fourteenth-century coroners' rolls to map the homicides in three medieval towns: London, York, and Oxford. These digital maps are interactive and come with podcasts of interesting cases,…

Promotie

De Staff Alliance for Equity (SAFE) is een bottom-upplatform dat openstaat voor medewerkers op alle niveaus, ongeacht hun contractuele status. De aanwezigheid en activiteiten van SAFE versterken onze toewijding aan de Gedragscode van de Faculteit Governance and Global Affairs, die ‘alle studenten en…

Duurzaamheid is een van de centrale aandachtspunten van de Universiteit Leiden en speelt een steeds grotere rol binnen het onderwijs en onderzoek van de Faculteit der Rechtsgeleerdheid. Binnen deze context levert de afdeling Sociaal Recht een belangrijke bijdrage aan het debat en onderzoek rondom Business…

Intelligente apparaten zullen ook ethische beslissingen gaan nemen. Mag een zelfrijdende auto voetgangers overrijden om de inzittenden te redden van een frontale botsing? Mag een onderhandelings-app stress in de stem van de tegenpartij detecteren? En wie bepaalt of dit mag, de gebruiker, de maker of…

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

Als gevolg van de grote technologische vooruitgang in de gezondheidszorg worden in toenemende mate gegevens verzameld tijdens de uitvoering van klinische onderzoeken.

In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.

Promotor: Prof.dr. M. Ubbink

Hydrogen peroxide (H2O2) is an important bulk chemical that is used in various industrial processes. More than 95% of the H2O2 used in industry is made via the anthraquinone process during which a large amount of energy is going to waste.

Promotor: A.P. IJzerman

Promotor: F.J. van Lunteren, E. Jorin

Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman

Multicopper oxidase, laccase, can efficiently reduce oxygen to water and are mostly used in the enzymatic biofuel cells.

Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.

Het Gorlaeus Gebouw wordt in drie fasen gerealiseerd. Het nieuwe gebouw is medio 2028 helemaal gereed.

Microbial rhodopsins are photosensitive pigments implemented in the growth and adaptation of a large population of microorganisms.

This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.

Before the large scale use of renewable energy sources can be implemented in our society, the storage of electrical energy needs to be tackled. Storage the energy as hydrogen via the reduction of protons is a good option.

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

Promotores: A.P. IJzerman, H.W.T. van Vlijmen

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Promotores: Prof.dr. H.J.M. de Groot, Prof.dr. J. Matysik (Universitaet Leipzig)