The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

This thesis explores Breaking of Ensemble Equivalence (BEE) in random graph models by examining the spectral properties of adjacency matrices. The goal is to identify spectral characteristics that differentiate random graph ensembles, enhancing the understanding of complex network structures and beh…

Organic amendments applied to agricultural fields can partially offset our carbon emissions to the atmosphere and improve the resilience of agriculture to the effects of climate change. Driving these benefits, however, are complex and poorly understood interactions between organic amendment properties,…

Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.

Cathodic corrosion is a relatively unknown phenomenon that can severely etch metallic electrodes at cathodic (negative) potentials.

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

Promotores: H.A. Udo De Haes, P.M. Brakefield

The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.

Promotor: Prof.dr. J.M. van Ruitenbeek, Prof.dr. R.M. Tromp

Promotor: Prof.dr. J. Kuiper

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

This thesis is concerned with the constitution of chiral responsive matrix assemblies that may undergo light-driven conformational changes and self-select vibrations to develop vibronic states for driving semi-classical coherent transfer with nearly 100% yield in a lossless NCAP process.

In the early universe, the dynamics of the Higgs field can give rise to many interesting phenomena.

Promotores: S.F. Portegies Zwart, E. M. Rossi

Plants and soils from natural ecosystems harbor great diversity of soil microorganisms, which could potentially contribute to the sustainability of horticulture. The knowledge about using wild plant species and soil from natural ecosystem to improve the crop health will advance the application of ecological…

Promotor: Prof.dr. W.Th.F. den Hollander, Co-promotor: R. Fernandez.

Constraint multi-objective optimization with a limited budget for function evaluations is challenging. This thesis tackles this problem by proposing new optimization algorithms. These algorithms are applied on holistic ship design problems. This helps naval architects balance objectives like cost, efficiency,…

Regeneration is the ability of an organism to restore damaged or lost tissue with a functional replacement, and without scarring. Many lizards can regenerate their tails.

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

Promotores: W. Th. F. den Hollander, M.O. Heydenreich

Low-carbon (LE) technologies have a significant potential to reduce the total carbon emissions in China.

This dissertation presents the results of the importance of creativity for ICT-students of Dutch universities of applied sciences (in Dutch: hogescholen), and the functioning of training courses that aim to promote creative abilities is highlighted.

Promotor: Prof.dr. M. de Jong

Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

In my research, I used a comparative wood anatomical approach to address wood evolution of the (largely) tropical flowering plant families Apocynaceae and Sapotaceae.

Promotor: Prof.dr. R. Verpoorte, Co-Promotores: N.R. Mustafa, A.E. Schulte

This thesis explores Breaking of Ensemble Equivalence (BEE) in random graph models by examining the spectral properties of adjacency matrices. The goal is to identify spectral characteristics that differentiate random graph ensembles, enhancing the understanding of complex network structures and beh…

The key characteristic of active matter is the motion of an emergent collection (such as a flock of birds), which is driven by the consumption of energy by its active components (i.e. individual birds).

The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.

In this thesis, rational points on K3 surfaces are studied. In the first part of Chapter 1 the Brauer group and the the Brauer-Manin obstruction are introduced.

Hospital pharmacies face significant challenges: the demand for sterile drug reconstitutions is increasing, while specialized personnel remain scarce. Automation offers a potential solution, but its practical implementation in hospitals is still unclear.

Promotor: H.J. van den Herik, B.R. Katzy, Co-promotor: K. Sailer

The applications of studying the early development of insects range from agriculture to material science.

De onderzoeksgroep Governance of Crises bestudeert fenomenen, dynamieken en actoren die te maken hebben met crisisgovernance. Het Crisis Research Center (CRC) van de Universiteit Leiden maakt deel uit van deze onderzoeksgroep.

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

Promotores: T.H. Oosterkamp, N. de Jonge

Promotor: B.van de Water, Co-promotor: L.S.Price

Promotor: Prof.dr. K.H. Kuijken, Co-Promotor: H.Hoekstra

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

This thesis focuses on developing wafer-scale two-dimensional (2D) materials by combining synthesis, transfer, characterization, and device integration of graphene, hexagonal boron nitride (h-BN), and BN-doped amorphous carbon.

Honoursonderwijs biedt studenten een extra uitdaging. In de onderwijsproeftuin volgen zij hun nieuwsgierigheid, treden ze buiten de gebaande paden en bereiden ze zich voor op de toekomst.

In this course, you will develop an understanding of evolutionary processes and their formative power. You will see how evolution has shaped biodiversity, and continuously influences our daily life.