This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.

Nanodiscs are small, disc-shaped structures designed to mimic biological cell membranes, composed of a lipid bilayer stabilized by scaffold proteins. Membrane proteins play crucial roles in essential processes such as nutrient and waste transport, molecular recognition, and cell signalling, making them…

Promotores: A.P. IJzerman, H.W.T. van Vlijmen

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Klinieken die het aantal kinderen per zaaddonor overschreden, kunnen mogelijk vrijuit gaan door een nieuwe juridische interpretatie. Experts zijn verontwaardigd. Mirjam Sombroek-van Doorm, hoogleraar Recht en Gezondheid sprak hierover met de NOS: ‘De norm was niet zomaar een ideetje.’

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

Voor studenten kan studeren in Den Haag het verschil maken. Den Haag draagt met trots de titel ‘internationale stad van vrede en recht’. Den Haag biedt volop kansen en is een geweldige studentenstad.

S.S. Kolipaka’s thesis questions and investigates the survival prospects of reintroduced tigers and their offspring’s in the human dominated landscape of Panna tiger reserve in India.

Het Leids Universitair Centrum voor de studie van Islam en Samenleving (LUCIS) is een interfacultair kenniscentrum dat een multidisciplinaire en vergelijkende benadering van islam en moslimsamenlevingen bevordert.

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

Promotor: J.W. van Holten

The solar system was formed approximately 4.56 billion years ago. Despite the numerous theories that have been developed over the years, the formation and evolution of the solar system still remain unclear.

This thesis investigates how galaxies form and what diversifies the evolutionary histories of galaxies.

In recent decades, climate change has led to more frequent and severe drought events, causing serious consequences such as increased forest mortality and significant crop yield losses. Understanding how drought affects plants, especially economically important herbaceous species, is crucial for predicting…

Promotores: B. Erez, P. Stevenhagen, Co-Promotor: B. de Smit

Op 12 januari 2022 verdedigde Mirjam Franke het proefschrift 'Over de grens van de onrechtmatige daad'. Het promotieonderzoek is begeleid door prof.mr. A.G. Castermans en prof.mr. J.H. Crijns.

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

An important part of the SCS specialisation is the internship period. Students will get the opportunity to get to know the field and to apply what they have learned during the courses.

Promotor: G.R. de Snoo, Co-promotor: H.H. de Iongh, C.J.M. Musters

Promotor: M. Franx, Co-Promotor: I.F. Labbé

Promotor: M.A.G.J. Orrit

Promotores: J. Kok, M. Chaudron (Chalmers University)

Promotor: Prof.dr. J.W.M. Frenken

Promotor: Prof.dr. E. Bouwman, Co-Promotor: S. Bonnet

The endophytic microbiota is a community of various microorganisms that reside in plant tissue. These microbes are known to promote plant health and resilience, and their members do not simply exist side by side.

Studievoorlichting

Studying the impact of urbanisation on the respiratory health of past Dutch populations (1200-1850 CE).

This thesis focuses on the study of transient and variable radio sources in the universe.

De voorgestelde beleidsmaatregelen zijn het resultaat van een interactief proces tussen medewerkers, studenten, de D&I adviesgroepen, externe experts en het Expertisebureau D&I.

We show that Kirchhoff ’s law of conservation holds for non-commutative graph flows if and only if the graph is planar. We generalize the theory of (Euclidean) lattices to infinite dimension and consider the ring of algebraic integers as such a lattice.

Promotor: Prof.dr. C.U. Keller

Single-Molecule Microscopy (SMM) techniques constitute a group of powerful imaging tools that enable researchers to study the dynamic behavior of individual molecules.

Promotores: H.W. Lenstra, B. Erez, Co-promotor: L. Taelman

We describe certain birational modifications of nodal relative curves over a regular base of arbitrary dimension.

Met het onderzoek ‘Baby’s eerste hapjes’ willen wij meer te weten komen over de overgang naar vast voedsel bij baby’s. Zo zijn we benieuwd hoe de overgang naar vast voedsel bij kinderen verloopt, hoe het eetpatroon van kinderen zich na de overgang verder ontwikkelt en hoe ouders deze overgang en het…

Migration imposes special pressures on the meaning, experience and organization of lifecycle rituals. These pressures are felt most strongly by Muslim migrants to Western Europe. In this innovative study, Nathal M. Dessing examines the effects of migration on the life cycle rituals of Moroccan, Turkish…

This thesis consists of three chapters. Each chapter is on a different subject. However, all three chapters address issues that arise in counting arithmetically interesting objects.

Multicellular giant algae Chara species have been widely used in physiological studies for decades.

Khadija Kadrouch-Outmany defended her thesis on 16 Septem ber 2016.

Promotor: A. Doelman, Co-promotor: M.F.E. de Jeu