This thesis focuses on protoplanetary disks: flattened structures of gas and dust around young stars in which planets are expected to form and grow.

Benieuwd wat de bachelor opleiding Economie & Samenleving bij Universiteit Leiden jou te bieden heeft? In vogelvlucht laten we het je zien.

Ontdek de extra uitdaging binnen de MSc Democracy and Representation aan Universiteit Leiden: het Leiden Leadership Programme en Master Honours Classes & Challenges met extra EC’s.

Ben jij een professional die een master wil doen? En heb jij een relevante achtergrond, zoals een HBO master of WO opleiding en enige jaren werkervaring? Dan kun je ervoor kiezen om je kennis in Cyber Security te verbreden en te verdiepen.

Haal zoveel mogelijk uit je studie aan de Univeriteit Leiden door deel te nemen aan onze extracurriculaire activiteiten.

The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…

A modern ship design process is subject to a wide variety of constraints such as safety constraints, regulations, and physical constraints.

Ontdek de extra uitdagingen bij de MSc Political Theory: Legitimacy and Justice aan Universiteit Leiden — zoals de Honours Academy, leadershiptrainingen en extra onderzoeks- of verdiepingstrajecten.

In this work, I explore the creation of new methods that optimize simulations of the gravitational N-body problem. Specifically, I take advantage of the recent popularity of Machine Learning methods to find tools that can suit this problem.

Surface acoustic waves (SAWs) are mechanical waves that travel along the surface of a material and find many applications in modern technologies due to the ease of excitation on piezoelectric substrates via interdigital transducers (IDTs).

The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.

Catharanthus roseus (Madagascar periwinkle) produces valuable monoterpenoid indole alkaloids (MIAs) such as vincristine and vinblastine, crucial for cancer treatment.

Haal zoveel mogelijk uit je studie aan de Univeriteit Leiden door deel te nemen aan onze extracurriculaire activiteiten.

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

This thesis investigates opinion dynamics on random graphs through the lens of the voter model, a classical interacting particle system used to describe how consensus emerges in networks.

Neurodegenerative diseases pose a large medical and societal challenge. The etiology of these diseases is still poorly understood, which makes drug discovery for these diseases difficult.

This thesis advances our understanding of lipid uptake, a vital first step in lipid metabolism, by developing innovative click chemistry-based tools to study how immune cells internalize lipids.

Wil je graag wat extra’s doen naast je studie? Daar is bij de Universiteit Leiden alle ruimte voor.

Ontdek hoe je je MSc Nederlandse Politiek kunt verrijken via extra uitdagingen zoals de Leiden Leadership Programme, honours‑classes en een onderzoeksstage.

A dense region of a gaseous and dusty cloud collapses to form a protostar surrounded by a disk and an envelope. This thesis uses both observations and models to study physical and chemical conditions of these protostellar systems which are likely where planets start to form.

This thesis examines the link between simple molecules and the underlying structure and chemistry within protoplanetary disks - the birthplaces of planets.

Promotor: Prof.dr. V. Icke, Co-Promotor: T.I. Madura

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

This dissertation combines the use of defined microenvironments, high-resolution fluorescence microscopy, and time-resolved analysis, to study intracellular and cellular motility.

SDN (Software-Defined Networking) represents a revolutionary approach to network architecture that enables the dynamic and flexible management of network resources through software-based control. This dissertation introduces the idea of SDN and its southbound protocol OpenFlow, then presents the formal…

With the help of quantum mechanics, digital quantum hardware may be able to tackle some of the problems that are too difficult for ordinary computers. But despite these expectations and the ongoing effort of the research community, reliable quantum computers are not yet realized in a lab setting.

Humans perceive the real world through their sensory organs: vision, taste, hearing, smell, and touch. In terms of information, we consider these different modesalso referred to as different channels of information or modals.

Promotor: Prof.dr. M.L. van Hecke

Ontdek de extra uitdaging binnen de MSc International Politics aan Universiteit Leiden: honours‑tracks, leadership programma’s en interdisciplinaire seminars.

Ontdek de extra uitdaging binnen de MSc Nationalism, Ethnic Conflict and Development aan Universiteit Leiden: honours‑trajecten, interdisciplinaire seminars en leadership programma’s.

Wil je graag wat extra’s doen naast je studie? Daar is bij de Universiteit Leiden alle ruimte voor.

The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.

“Temminck’s Order” is the scientific biography of Coenraad Jacob Temminck (1778–1850), a Dutch naturalist and the first director of ’s Rijks Museum van Natuurlijke Historie in Leiden.

Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.

In het schoolvak scheikunde is de concept-context benadering ingevoerd. Hans Vogelzang onderzocht of de Scrum-methodologie kan helpen bij het vormgeven van lessen met deze benadering.

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

Modeling and analysis of cyber-physical systems are still challenging. One reason is that cyber-physical systems involve many different parts (cyber or physical), of different nature (discrete or continuous), and in constant interaction via sensing and actuating.

Songbirds as vocal learners learn their songs and song preference from social tutors⁠. Tutor choice for both song and preference learning are important to characterize for understanding individual learning performance and cultural transmission of song⁠.

Promotores: Prof.dr. H. van Veen & Prof.dr. W. de Boer (Wageningen University)

Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.

This thesis investigates how quantum, quantum-inspired, and hybrid quantum-classical computation can enhance key points of the automated machine learning (AutoML) pipeline under the constraints of noisy intermediate-scale quantum (NISQ) devices.

If X is a locally compact Hausdorff space, then a representation of the complex C* algebra C_0(X) on a Hilbert space $H$ is given by a spectral measure that takes its values in the orthogonal projections on $H$.

Despite the history of studies on methanol formation from CO2, the dominant elementary reaction steps that constitute the chemical mechanism for this catalyzed process are not determined.

The investigation into the bidirectional communication between the gut and its host is a rapidly growing area of research, attracting considerable attention for its potential to provide crucial insights into health and disease.

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

In this thesis I highlight the applications of Oxford Nanopore Technologies (ONT) sequencing. This technique is a relatively new approach in the sequencing field, where nanopores are embedded in a membrane, DNA molecules are pulled through nanopores and an electrical current serving as the sequencing…

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

Al eeuwenlang wordt in Nederland bij overlijden belasting geheven over de verkregen erfenissen. De heffing van deze erfbelasting staat niet alleen ter discussie vanwege de vermeende dubbele heffing en het beklemmende aanknopingspunt, maar ook vanwege de mogelijkheden om via slimme juridische constructies…

Promotor: Prof.dr. B.R. Katzy