Promotor: F.H.J. Redig, Co-Promotor: W.T.F. den Hollander

Promotor: P.D. Grünwald

This thesis discusses several questions regarding the double ramification cycle as a Chow class on the moduli space of stable n-pointed genus g curves using tools from so-called logarithmic geometry.

This dissertation consists of two parts, with the common theme

Promotor: R. Cramer

Promotor: K.J. Batenburg, Co-promotor: A.W. van der Vaart, B. de Smit

Promotor: S.J. Edixhoven, Co-promotor: R.S. de Jong

The research in this thesis is focused on tomographic reconstruction based on two imaging modalities in electron microscopy.

This dissertation presents new cryptographic protocols, which can be divided into two families.

Promotor: S.M. Verduyn Lunel, Co-promotores: M.F.E. de Jeu, B. de Pagter

De Universiteit Leiden heeft onderzoeksinstituten gevestigd in Leiden en Den Haag.

We study the interplay of topology and geometry with chirality for several passive and active systems, employing both analytical and numerical methods.

Gibbs measures, as used in Statistical Mechanics, have a definition that is remarkably similar to the definition ofg-measures, used in dynamical systems.

This thesis explores Breaking of Ensemble Equivalence (BEE) in random graph models by examining the spectral properties of adjacency matrices. The goal is to identify spectral characteristics that differentiate random graph ensembles, enhancing the understanding of complex network structures and beh…

One of the effects of climate change is the phenomenon of desertification, a process that occurs in semi-arid and arid areas and causes land degradation as well as vegetation loss. Due to the lack of resources, vegetation self-organizes to sustain itself by forming large-scale spatial patterns.

Combinatorial games are games for two competing players, moving in a turn-by-turn fashion, in which there is no chance nor hidden information⁠. Chess, checkers and the simpler tic tac toe are well-known examples of this class of games, as well as game of go⁠.

Arithmetic geometry concerns the number-theoretic properties of geometric objects defined by polynomials. Mathematicians are interested in the rational solutions to these geometric objects.

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

This thesis studies the geometry of representation varieties and character stacks. These are spaces parametrizing the representations of a finitely generated group, typically the fundamental group of a compact manifold, into an algebraic group G.

This monograph focuses on clustering of objects in high-dimensional data, given the restriction that the objects do not cluster on all the attributes, not even on a single subset of attributes, but often on different subsets of attributes in the data.

In this thesis, rational points on K3 surfaces are studied. In the first part of Chapter 1 the Brauer group and the the Brauer-Manin obstruction are introduced.

Na het afronden van de bacheloropleiding volgen verreweg de meeste studenten de masteropleiding.

If X is a locally compact Hausdorff space, then a representation of the complex C* algebra C_0(X) on a Hilbert space $H$ is given by a spectral measure that takes its values in the orthogonal projections on $H$.

Classical statistical methods, such as p-values, are difficult for researchers to apply correctly. They for example do not allow drawing conclusions from a study early, or for extending a study with extra research groups that want to make their data available later.

Artful Mathematics: The Heritage of M. C. Escher

Promotor: Prof.dr. H.W. Lenstra

Promotor: Prof.dr. A. Doelman, Co-promotor: V. Rottschäfer

Promotor: S.M. Verduyn Lunel, Co-promotor: O.W. van Gaans

In this thesis we study bistable reaction-diffusion equations on lattice domains.

This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.

Vast, often populated, areas in dryland ecosystems face the dangers of desertification.

Promotor: Bas Edixhoven, Promotor: Qing Liu

Science is typically a patchwork of research contributions without much coordination. Especially in clinical trials, the follow-up studies that we do fail to be the most promising.

The subject of this thesis, ‘Approach to Markov Operators on Spaces of Measures by Means of Equicontinuity’, combines an analytical and probabilistic approach to Markov operators.

This thesis investigates opinion dynamics on random graphs through the lens of the voter model, a classical interacting particle system used to describe how consensus emerges in networks.

De Nobelprijs voor Scheikunde 2017 is uitgereikt aan Jacques Dubochet, Richard Henderson en Joachim Frank, voor hun ontwikkeling van de cryo-elektronenmicroscopie. Met deze techniek kunnen biomoleculen in 3D in beeld gebracht worden, legt hoogleraar Ultrastructuurbiologie Ariane Briegel uit.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Biodiversity enables ecosystems to thrive through the synergy of functional differences among organisms. While human well-being strongly depends on biodiversity-driven ecosystem services, human actions are also at the root of current unprecedented biodiversity declines.

Overkleeft

Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

Promotores: W.J.G.M. Peijnenburg, G.R. de Snoo, Co-promotor: M.G. Vijver

Dit proefschrift beschrijft een collectie aan alternatieve strategieën voor het begrijpen, ontwerpen en toepassen van lipide nanosystemen, waarin de rol van de bio-nano interacties centraal staan. In het bijzonder wordt gekeken naar de interactie van RNA-lipide nanosystemen, bekend van de toepassing…

Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

This thesis focuses on the design and synthesis of activity-based probes and inhibitors targeting enzymes involved in the degradation of specific plant glycans.

This thesis explores squaramide-based supramolecular polymers and hydrogels, enhancing their mechanical strength for 3D cell culture.

The primary goal of this research is to deepen our understanding of substrate-enzyme interactions in Glycoside hydrolases. For this purpose, Bacillus circulans xylanase (BcX) has been selected as a well-established model to examine the Michaelis complex and glycosyl-enzyme adduct.

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.