The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

Promotors: Prof.dr. P.J. Punt, Prof.dr. C.A.M.J.J. van den Hondel

Complex Organic Molecules (COMs) have been detected in objects across different stages of stellar evolution.

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

Promotor: Prof.dr. E. Bouwman, Co-Promotor: S. Bonnet

Are you planning to conduct clinical research in the Netherlands? In this online course, you are introduced to legislation and procedures on clinical research in the Netherlands. It will help you prepare and submit your research file efficiently. The first three themes ‘The Dutch Review System’ , ‘The…

In this thesis chemical and physical processes in the ice mantles on interstellar dust grains are studied.

Promotores: W.J.G.M. Peijnenburg, G.R. de Snoo, Co-promotor: M.G. Vijver

Dissochaeta Blume (Melastomataceae, tribe Dissochaeteae) is well-known as a scrambling plant genus found in Southeast Asia, where it is an inhabitant of the tropical rainforests or evergreen forests.

This dissertation aims to advance understanding of amoeboid single cell migration under the influence of changing physicochemical environmental properties. The particular focus is on the relatively unknown influence of differing physical properties in the extracellular environment, such as the migratory…

Nanodiscs are small, disc-shaped structures designed to mimic biological cell membranes, composed of a lipid bilayer stabilized by scaffold proteins. Membrane proteins play crucial roles in essential processes such as nutrient and waste transport, molecular recognition, and cell signalling, making them…

Galaxies in the local Universe fall into two main categories of spirals and ellipticals. In this Thesis, we explore the structural evolution of galaxies into this bimodal distribution.

In this work, I explore the creation of new methods that optimize simulations of the gravitational N-body problem. Specifically, I take advantage of the recent popularity of Machine Learning methods to find tools that can suit this problem.

The radio sky harbours both galactic and extragalactic sources of arcminute- to degree-scale emission of various physical origins. To discover extragalactic diffuse emission in the Cosmic Web beyond galaxy clusters, one must image low–surface brightness structures amidst a sea of brighter compact fore-…

Explore "Surgical anatomy of the leg in relation to nerve injuries" at Boerhaave Nascholing. Read more here.

Decarbonizing the building stock is critical for realizing the climate-neutral target for the Netherlands.

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

Op 1 juni 2022 verdedigde Tom Herrenberg het proefschrift 'Prosecutorial Discretion in International Criminal Justice'. Het promotieonderzoek is begeleid door prof.dr. P.B. Cliteur en prof.dr. B.R. Rijpkema.

The parabolic Anderson model (PAM), which is the Cauchy problem for the heat equation with random potential. The PAM is a mathematical model that describes how mass (i.e. matter or energy) flows in a medium in the presence of a field of sources and sinks.

In eight chapters, the thesis of Rafaël Vos covers the effect of temperature and pressure on the electrochemical CO2 reduction.

Radio jets are important to the evoultion of galaxies. However, it is still not fully understood how a radio jet can be triggered.

Promotor: V. Vitelli, Co-promotor: J. Paulose

Promotor: Prof.dr. A. Doelman, Co-promotor: V. Rottschäfer

To address the fundamental questions of how life on Earth emerged and how common life may be in the Universe, it is crucial to know the chemical composition of the planet-forming material.

Promotores: H.A. Udo de Haes, H.H.T. Prins, Co-promotor: H.H. de Iongh

Regeneration is the ability of an organism to restore damaged or lost tissue with a functional replacement, and without scarring. Many lizards can regenerate their tails.

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

Intensive care-afdelingen overal ter wereld kunnen hun doseringen voor morfine bij baby’s en peuters gaan aanpassen. Met een nieuwe methode ontdekte farmacologe Elke Krekels dat gebruikelijke doseringen bij pasgeborenen te hoog zijn, en bij peuters juist te laag. Promotie 10 oktober.

Op 3 september 2019 verdedigde Ilektra Antonaki haar proefschrift 'Privatisations and golden shares: Bridging the gap between the State and the market in the area of free movement of capital in the EU'. Het promotieonderzoek is begeleid door promotor prof.dr. S.C.G. Van den Bogaert.

Promotor: M. Franx, Co-Promotor: I.F. Labbé

Voltammetry plays a crucial role in modern scientific research by offering valuable insights into the electrochemical properties of materials, with wide-ranging applications in fields such as materials science, energy storage, corrosion studies, and sensor development.

This thesis focus on the interaction between M dwarf stellar winds and Galactic cosmic rays and the possible effects on the habitability of exoplanets.

The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.

Promotor: Prof.dr.ir. E. Deprettere

One of the key quests in astronomy is to study the growth and evolution of galaxies across cosmic time. Radio observations provide a powerful means of studying the formation of stars and subsequent buildup of distant galaxies, in a way that is unbiased by the presence of dust.

Humans and songbirds learn their vocalizations early in life by exposure to the vocalizations of adult conspecifics. Often, better learning outcomes are achieved with live, social, tutors than with audio-only exposure to vocalizations.

Who are open-source intelligence activists and how reliable are their contributions to public understanding of Russia’s war in Ukraine?

Op 16 december 2019 verdedigde Jan-Harm de Villiers zijn proefschrift 'The Anthropomorphic Hegemony of Subjectivity: Critical Reflections on Law and the Question of the Animal'. Het promotieonderzoek is begeleid door promotor prof.dr. P. Cliteur.

In dit artikel presenteren Kellerman en Seddon een nieuw conceptueel kader waarin het concept van marktleesbaarheid centraal staat.

Op 15 februari 2022 verdedigde Morshed Mannan het proefschrift 'The Emergence of Democratic Firms in the Platform Economy: Drivers, Obstacles, and the Path Ahead'. Het promotieonderzoek is begeleid door prof.mr. I.S. Wuisman en prof.dr. J.A.A. Adriaanse.

The thesis focuses on synthesis strategies in oligosaccharide campaigns, and the influence of protecting groups.

Promotores: Prof.dr. J. Schaye & Prof.dr. C. Steidel (California Institute of Technology)

In unconventional high temperature superconductors, supercurrent vortices are known to spoil the Landau levels. In this thesis the emergence of Landau levels is studied in different types of superconductors: Weyl superconductors, and the Fu-Kane heterostructure.

Announcement of the publication of Vamping the Stage: Female Voices of Asian Modernities, the first book-length study of women, modernity, and popular music in Asia (University of Hawai'i Press, 2017).

Promotores: J. Jonkers, K.E. de Visser

All crested and marbled newts (the genus Triturus) suffer from an unusual genetic abnormality, called a balanced lethal system, that kills exactly half of their offspring. How can a trait so disadvantageous have survived millions of years of natural selection?

Let A be a commutative algebraic group over a field K, and let G be a finitely generated subgroup of the K-rational points of A. The purpose of this thesis is to study the degrees of the Kummer extensions relative to A,K and G.