1,559 zoekresultaten voor “complex netwerk” in de Publieke website
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Towards automated identification of metabolites using mass spectral trees
Promotor: Prof.dr. T. Hankemeier, Co-promotor: Theo Reijmers
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Understanding teacher agency in universities: why and how lecturers shape and navigate university teaching practices
In het proefschrift van Max Kusters (promovendus bij het ICLON) werd ‘teacher agency’ onderzocht: het vermogen van universitaire docenten om hun onderwijspraktijk en werkomstandigheden actief en doelgericht te beïnvloeden.
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Pulling the strings on anti-cancer immunity
Promotores: J. Jonkers, K.E. de Visser
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Women Writing Mexico (WWM)
Women Writing Mexico (WWM) is a network of women and men concerned with the human rights crisis in Mexico and more specifically, with the impact of structural forms of poverty, everyday violence, and discrimination based on gender, race, social class, and ethnicity, that particularly have an impact…
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Photocleavable activity-based acid glucosylceramidase probes
Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…
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Over het project
De nieuwbouw voor de Faculteit der Wiskunde en Natuurwetenschappen is een belangrijke mijlpaal voor de Universiteit Leiden en de faculteit in het bijzonder. In drie fasen wordt een nieuw gebouw gerealiseerd. De eerste fase van het nieuwe gebouw is in 2016 in gebruik genomen en beslaat 45.000m2. Het…
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Destroy, Create, Transform and Sublimate. Laboratory Dissociation Studies on Polycyclic Aromatic Hydrocarbons and Analogues
The aromatic infrared bands (AIBs) seen throughout the interstellar medium (ISM) are generally thought to be carried by polycyclic aromatic hydrocarbons (PAHs) and their nitrogen analogues (PANHs).
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Unravelling cell fate decisions through single cell methods and mathematical models
Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.
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Applying data mining in telecommunications
This thesis applies data mining in commercial settings in the telecommunications industry.
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Triblock polypept(o)ides for siRNA delivery: unique polymeric designs for versatile carrier systems
Utilizing the polymeric platform of polypept(o)ides, this thesis describes synthesis and investigation of novel triblock copolymers to obtain carrier systems with multiple compartments for efficient siRNA delivery. Although the individual microstructure of nanoparticles differs depending on the polymeric…
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Protein arginine methyltransferases as modulators of lipid metabolism and inflammation and the relevance for atherosclerosis
Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…
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Coiled-coils on lipid membranes: a new perspective on membrane fusion
Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros
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Beyond random and forbidden interactions : how optimizing energy gain results in morphological matching among subalpine Asteraceae and their
Plants and their pollinators form complex interaction networks. Within these networks, species differ widely in the number of species they interact with.
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Roderick Scherptong
Implementatie van interprofessioneel leren
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VERBODEN TOEGANG! – Het recht op onderwijs voor meisjes, met een focus op Pakistan
Welke uitdagingen bestaan er voor meisjes in het uitoefenen van hun recht op onderwijs en in het bijzonder het krijgen van toegang tot onderwijs?
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Extra uitdaging
Bekijk de extra uitdagingen binnen de MSc International Organisation (Leiden). Ontdek het Honours-programma, Leiden Leadership Programme en academische challenges.
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Key innate immune components controlling intracellular infection
Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer
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De strijd van gelijkheid en vrijheid
Moeten alle mensen gelijk worden behandeld? En alle opvattingen? Een bevestigend antwoord op deze vragen ligt voor de hand.
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Transformation and sublimation of interstellar ices: insights from laboratory experiments and astronomical observations
Stars and planets form within cold, dense clouds of gas and dust drifting through interstellar space. Although dust makes up only a small fraction of this material, it plays a key role in shaping the chemical evolution of these environments.
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Extracurriculair
Haal zoveel mogelijk uit je studie aan de Univeriteit Leiden door deel te nemen aan onze extracurriculaire activiteiten.
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Anisotropy, multivalency and flexibility-induced effects in colloidal systems
We have studied the impact of particle shape anisotropy, multivalent interactions and flexibility on systems of micron-sized colloidal particles.
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High-throughput profiling of small molecules using mass spectrometry
Promotor: Prof.dr. T. Hankemeier
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A semisynthetic peptide-metalloporphyrin responsive matrix for artificial photosynthesis
This thesis is concerned with the constitution of chiral responsive matrix assemblies that may undergo light-driven conformational changes and self-select vibrations to develop vibronic states for driving semi-classical coherent transfer with nearly 100% yield in a lossless NCAP process.
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Terugkeerders uit Jihadistische strijdgebieden
In dit vierde rapport worden ontwikkelingen besproken ten aanzien van het beleid met betrekking tot personen die terugkeren uit jihadistische strijdgebieden, zogeheten ‘terugkeerders’, voor de periode januari 2017 tot medio december 2018.
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Potential interference of fungal endophytes in Vanilla planifolia on vanilla flavor compounds biosynthesis
Natural vanilla flavor is one of the most important in the world. However, the cost of this flavor is expensive. Production of this flavor by alternative methods, could reduce the cost.
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Algorithms for the description of molecular sequences
Promotor: J.N. Kok, P.E. Slagboom Co-promotor: J.F.J. Laros
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Exploitation of host chemokine signalling by pathogenic mycobacteria
Promotores: A.H. Meijer, H.P. Spaink
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On the degree of Kummer extensions for commutative algebraic groups
Let A be a commutative algebraic group over a field K, and let G be a finitely generated subgroup of the K-rational points of A. The purpose of this thesis is to study the degrees of the Kummer extensions relative to A,K and G.
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Computational speedups and learning separations in quantum machine learning
This thesis investigates the contribution of quantum computers to machine learning, a field called Quantum Machine Learning. Quantum Machine Learning promises innovative perspectives and methods for solving complex problems in machine learning, leveraging the unique capabilities of quantum computers…
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The electrochemical reduction of dioxygen and hydrogen peroxide by molecular copper catalysts
The electrochemical oxygen reduction reaction (ORR) is an essential half-reaction for the utilization of hydrogen as a sustainable fuel, via the conversion of hydrogen to electrons and protons facilitated by the ORR. In the most common fuel cells, the ORR is requires high loadings of non-abundant platinum…
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LUMC HoofdgebouwAlbinusdreef 2, Leiden
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Exploring chemical space in covalent and competitive glycosidase inhibitor design
Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency
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The urge to collect
Where does the urge to collect come from? What are the explicit or underlying reasons for gathering large amount of objects?
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Surface-structure dependence of water-related adsorbates on platinum
Promotor: M.T.M. Koper, Co-promotor: J.B.F. Juurlink
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Replacing the needle and syringe for vaccine administration
Promotores: Prof.dr. G.F.A Kersten, Prof dr. J.A. Bouwstra
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Multi-dimensional feature and data mining
In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.
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Good governance and the rule of law
Op welke manier ontwikkelt de ‘rule of law’ zich in Westerse samenlevingen in het licht van de opkomst en verspreiding van diverse digitale technologieën en hoe kan de rule of law invloed hebben op het gebruik en de verspreiding van deze technologieën.
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More is alive: emergent multi-scale order & collective flows in tissues
The overarching goal of this thesis is to set the foundations, but also make the first essential steps towards establishing a comprehensive, mesoscopic, hydrodynamic theory of epithelial tissues. The stage is set by an exhaustive study of topological defects in passive p-atic liquid crystals, singularities…
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What's in the diet? DNA-based analysis for qualitative and quantitative assessment of animal diet
Animal diet studies are critical for understanding ecological processes such as trophic interactions, energy flow, and nutrient cycling. By examining what animals consume, ecologists gain insights into species specialization, predator-prey relationships, and ecosystem management.
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Opportunity and Problem in Context (OPiC). A framework for environmental management in developing countries
Promotor: W.T. de Groot
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Grenzeloze InterEsse
Leren gaat het makkelijkst vanuit interesse. Maar die interesse is vaak meervoudig, en waaiert diverse kanten uit. Hoe richt je het onderwijs daarop in?
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Extracurriculair
Haal zoveel mogelijk uit je studie aan de Univeriteit Leiden door deel te nemen aan onze extracurriculaire activiteiten.
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Synthetic carbohydrate ligands for immune receptors
One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.
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Volatile compounds from Actinobacteria as mediators of microbial interactions
Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.
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Het miljard deeltjes probleem
Promotor: Prof.dr. S. Portegies Zwart
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When galaxy clusters collide: the impact of merger shocks on cluster gas and galaxy evolution
Promotor: Prof.dr. H.J.A. Rottgering
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Reactivity of cobalt(II)-dichalcogenide complexes: correlation between redox conversion and ligand-field strength
The redox-conversion reaction of metal-disulfide and metal-thiolate complexes are important, as they may shed light on electron-transfer reactions that often occur in Nature.
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Evolutionary diversification and historical biogeography of Orchidaceae in Central America with emphasis on Costa Rica and Panama
In this thesis, I targeted the orchid genus Lepanthes, one of the six genera of angiosperms that surpasses 1,000 species in the Neotropics, as a study model to investigate the evolutionary processes that promoted species diversifications.
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Interactions from lipid membrane deformations
Biological cells, the basic building blocks of all life forms, are surrounded by a lipid membrane. More than half of the membrane is occupied by membrane proteins, which can regulate the cell functionality through specific arrangements.
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Microphysiological liver systems for in vitro modeling and industry implementation
This thesis tackles the difficulty of predicting the liver’s clinical response to novel therapies, a challenge arising from interspecies differences and limitations of existing in vitro models.