Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).

This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…

Current therapies for patients with atherosclerosis are targeted primarily on reducing blood cholesterol, but this fails to prevent a large number of cardiovascular events.95 In order to identify new therapeutic strategies for treating atherosclerosis, it is important to study the interactions between…

Promotores:Th.J.C. van Berkel, M. van Eck

On a structural level, the properties featured by a majority of mechanical metamaterials can be ascribed to the finite number of soft internal degrees-of freedom allowing for low-energy deformations.

In de design fase werk je aan het onderzoeken van een slimme oplossing voor het probleem en het schrijven van een businessplan.

Bestuursprocesrecht in constitutioneel-rechtsvergelijkend perspectief.

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

In 2021 heeft het NCSC de Universiteit Leiden gevraagd om een rapid review uit te voeren naar best practices en mogelijkheden voor vervolgonderzoek over de integratie van gedragswetenschappen in security by design methodologieën en projecten. Dit academische veld wordt security by behavioural design…

Welkom, en leuk dat je geïnteresseerd bent in Designing Your Life-onderwijs! Of je nu student bent of onderwijs ontwikkelt, deze website heeft alles wat je nodig hebt om met DYL aan de slag te gaan.

De auteurs zoeken en beoordelen systematisch relevante definities van Security by Design (SbD) in vergelijking met Privacy by Design (PbD).

In the first part of this thesis we study the geometry of folding patterns.

Bij onderwijsvernieuwing wordt vaak nascholing ingezet, maar die is niet altijd effectief. In haar proefschrift onderzocht Nienke Wieringa (ICLON) welke ondersteuning docenten nodig hebben bij onderwijsvernieuwing.

Promotor: A.P. IJzerman

To design the ideal water oxidation catalyst, understanding of the catalytic mechanism and decomposition pathways is essential.

Promotor: E. Bouwman, Co-promotor: S. Bonnet

Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)

Vallejo

Promotor: Prof.dr. T.H.W. Bäck

A modern ship design process is subject to a wide variety of constraints such as safety constraints, regulations, and physical constraints.

Onderzoeken en ontwerpen zijn twee vaardigheden die steeds belangrijker worden in de vakken O&O (onderzoeken en ontwerpen) en NLT (natuur, leven en technologie). Uit onderzoek van Tessa Vossen (ICLON en Faculteit Wiskunde en Natuurwetenschappen) blijkt dat docenten en leerlingen de relevantie van onderzoeken…

Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.

Multi-objective evolutionary computation aims to find high quality (Pareto optimal) solutions that represent the trade-off between multiple objectives.

Viral diseases constitute one of the major challenges in modern medicine. Membrane-targeting have broad-spectrum potential and could distinguish viral membranes from the host cell plasma membrane by the difference in membrane curvature.

This thesis describes the design, characterization and application of dextran based crosslinked network.

Electoral Systems and Turnout: Evidence From a Regression Discontinuity Design. In dit artikel, gepubliceerd op de website SAGE research methods, bespreken auteurs Jaroslaw Kantorowicz en Tobias M. Hlobil hoe een Regression Discontinuity Design uitgevoerd kan worden.

Promotores: J. Kok, M. Chaudron (Chalmers University)

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

Wat is een goede wetgeving inzake gegevensbescherming? Hoe kan een dergelijke wetgeving goed worden ontwikkeld? Is de Europese wetgeving hierover adequaat, en is deze toepasbaar in China?

Promoter: Ed F. Deprettere, Co-promoter: Todor P. Stefanov

CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…

Met dit project wordt van een evidence-based onderwijsmethodiek (toolkit) ontwikkeld voor docenten van alle vakgebieden in het hoger onderwijs voor het effectief omgaan met controversiële onderwerpen in de les.

How to contribute to a quantum leap of eco-industrial symbiosis in China?

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

In design optimization problems, engineers typically handcraft design representations based on personal expertise, which leaves a fingerprint of the user experience in the optimization data. Thus, learning this notion of experience as transferrable design features has potential to improve the performance…

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

This thesis describes the design, synthesis, and immunological evaluation of varying (neo)antigenic peptide conjugates containing either a TLR2 or a TLR7 agonist.

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

A convolutional neural network (CNN) is a biologically inspired algorithm, highly capable at processing images and videos.

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M.R.V. Chaudron, Co-Promotor: M.T.M. Emmerich

Promotores: Prof.dr. G. Miley & Prof.dr. J.M. van den Broek

Utilizing the polymeric platform of polypept(o)ides, this thesis describes synthesis and investigation of novel triblock copolymers to obtain carrier systems with multiple compartments for efficient siRNA delivery. Although the individual microstructure of nanoparticles differs depending on the polymeric…

This thesis addresses questions on effectively using variational quantum circuits for machine learning tasks.

Nicolaes Tulp (1593-1674) studeerde Geneeskunde in Leiden. Hij volgde college in het Academiegebouw en kreeg anatomieles in de voormalige Faliede Begijnkerk, nu een vleugel van het gebouw ‘de Oude UB’, waar lange tijd het anatomisch theater was gevestigd. Kort na zijn verhuizing naar Amsterdam portretteerde…

Whilst government’s ability to design ‘context-specific’ regional innovation policy is generally assumed to depend on the region’s decision-making power, the aim of this study is to investigate how regional government matters. In order to open up the black box of policy design, the study develops a…

Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…