1,600 zoekresultaten voor “computational modelling” in de Publieke website
-
Liposome-based synthetic long peptide vaccines for cancer immunotherapy
Promotores: Wim Jiskoot; Ferry Ossendorp
-
Pulling the strings on anti-cancer immunity
Promotores: J. Jonkers, K.E. de Visser
-
Netwerkanalyse onthult onvermoede maatschappelijke patronen
Dankzij data science kunnen we grote hoeveelheden van gerelateerde informatie in kaart brengen en doorzoeken. Dit levert allerlei nieuwe inzichten op, bijvoorbeeld in wereldwijde complexe financiële structuren of sociaal-maatschappelijke problemen als eenzaamheid.
-
Uniform infinite and Gibbs causal triangulations
Promotor: Richard D. Gill
-
Lipid mediated colloidal interactions
The lipid membrane is a basic structural component of all living cells. Embedded in this nanometer-thin barrier, membrane proteins shape the membrane and at the same time respond to the shape of the membrane.
-
Structural Health Monitoring Meets Data Mining
Promotor: Prof.dr. J.N. Kok, Co-promotor: A.J. Knobbe
-
When data compression and statistics disagree: two frequentist challenges for the minimum description length principle
Promotor: P.D. Grünwald
-
Ruthenium-peptide conjugates for targeted phototherapy
As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.
-
Laboratoria Digital Archaeology
De onderzoeksgroep Digital Archaeology beheert twee computerlaboratoria voor verschillende doeleinden: een onderwijslab en een onderzoekslab.
-
Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
-
Monitoring Alzheimer's disease in transgenic mice with ultra high field magnetic resonance imaging
Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia
-
Vakbeschrijvingen
De basis van de studie is voor alle Bestuurskundestudenten hetzelfde, een deel van de vakken verschilt per specialisatie. Bij Digitalisering, Data en Governance slaan deze vakken een brug tussen de digitale en bestuurskundige wereld. Hieronder vind je de beschrijvingen van de DDG - vakken in het eerste,…
-
Cancer chess: molecular insights into PARP inhibitor resistance
The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…
-
Invariant manifolds and applications for functional differential equations of mixed type
Promotor: S.M. Verduyn Lunel
-
Franco Donati
Wiskunde en Natuurwetenschappen
-
Concepts and applications for evidence-based dosing in morbidly obese patients before and after weight loss surgery
Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst
-
Dual Complexes of Semistable Varieties
This thesis is comprised of three chapters covering the theme of studying semistable varieties by looking at their dual combinatorial objects.
-
Onze mensen
Dit zijn de mensen die binnen de Universiteit Leiden actief zijn op het gebied van kunstmatige intelligentie.
-
Studieprogramma
De studie leert je om mee te denken over de beleidsmatige aanpak van belangrijke kwesties binnen onze samenleving. Het gaat vaak om complexe vraagstukken, waar je zelf de weg in moet vinden. Het studieprogramma maakt je daar stapsgewijs klaar voor.
-
Metabolomics assisted with stable-isotope labeling: exploring neuronal metabolism related to Parkinson’s disease
The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.
-
Nanomaterial safety for microbially-colonized hosts: Microbiota-mediated physisorption interactions and particle-specific toxicity
The external tissues of plants and animals are colonized by microbial communities termed microbiota. When organisms are exposed to environmental pollutants, these substances will therefore encounter microbiota at the exposure interface.
-
Filter-based reconstruction methods for tomography
Promotor: K.J. Batenburg
-
Large scale visual search
Promotor: J.N. Kok, Co-promotor: M.S. Lew
-
Dark ice chemistry in interstellar clouds
This thesis is largely an experimental study on the formation of solid-state simple and complex organic molecules in the H2O-rich and CO-rich ice phases of dense interstellar clouds and dark cores.
-
Two-Prover Bit-Commitments: Classical, Quantum and Non-Signaling
This thesis considers multi-prover commitment schemes whose security is based on restrictions on the communication between the provers.
-
Clavis Aurea? Structure-enabled approaches of identifying and optimizing GPCR ligands
Promotores: A.P. IJzerman, H.W.T. van Vlijmen
-
Inhibitors and activity-based probes for β-D-glucuronidases, heparanases and β-L-arabinofuranosidases
Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.
-
The hunt for frozen organic molecules in space
Complex Organic Molecules (COMs) have been detected in objects across different stages of stellar evolution.
-
Vervolgopleidingen
Wil je een volledige academische opleiding? Dan ga je na je bachelor door met een masteropleiding. Met een masterdiploma op zak heb je meer kans op een baan op academisch niveau. Na afronding krijg je de titel Master of Arts (MA).
-
Towards automated identification of metabolites using mass spectral trees
Promotor: Prof.dr. T. Hankemeier, Co-promotor: Theo Reijmers
-
Regulation of actomyosin contraction as a driving force of invasive lobular breast cancer
In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).
-
The endocannabinoid system in zebrafish larvae
In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.
-
Amie Corbin
Wiskunde en Natuurwetenschappen
-
Dirk-Jan Kok
Wiskunde en Natuurwetenschappen
-
Weilin Huang
Wiskunde en Natuurwetenschappen
-
Mathilde Verdam
Faculteit der Sociale Wetenschappen
-
Nicolas Navarre
Wiskunde en Natuurwetenschappen
-
Anne Uilhoorn
Wiskunde en Natuurwetenschappen
-
Carina Harpprecht
Wiskunde en Natuurwetenschappen
-
Myrthe Veenman
Faculteit der Sociale Wetenschappen
-
Franz Wurm
Faculteit der Sociale Wetenschappen
-
Jinhui Zhou
Wiskunde en Natuurwetenschappen
-
Geert-Jan Will
Faculteit der Sociale Wetenschappen
-
Akrati Saxena
Wiskunde en Natuurwetenschappen
-
Felix Frohnert
Wiskunde en Natuurwetenschappen
-
Nils Thonemann
Wiskunde en Natuurwetenschappen
-
Studying the Benefits of Using UML on Software Maintenance: an Evidence-Based Approach.
Including modelling as part of software development appears to have various benefits.
-
Data Science
Het merendeel van de wetenschappers, van archeologen tot zoölogen, verzamelt enorme hoeveelheden gegevens. Hun databanken bevatten grote hoeveelheden informatie die voor de mens moeilijk te filteren zijn. Met een stevige basis in de statistiek en de computerwetenschappen kunnen we algoritmes ontwikkelen…
-
Into the Darkness: Forging a Stable Path Through the Gravitational Landscape
In this thesis we study the landscape of gravitational models which modify GR by introducing an additional scalar degree of freedom (d.o.f.) to source Cosmic Acceleration.
-
Data-driven donation strategies: understanding and predicting blood donor deferral
The research in this dissertation aims to optimise blood donation processes in the framework of the Dutch national blood bank Sanquin. The primary health risk for blood donors is iron deficiency, which is evaluated based on donors' hemoglobin and ferritin levels.