1,208 zoekresultaten voor “drug development” in de Publieke website
-
George Miley
Wiskunde en Natuurwetenschappen
-
Jennifer Anderson
Wiskunde en Natuurwetenschappen
-
Nieuwe hoogleraar gaat medicijnen ontwikkelen binnen academische wereld
Internist- klinisch farmacoloog Teun van Gelder is per 1 december 2019 benoemd tot Leidse hoogleraar Drug Discovery & Development. Hij zal zich bezighouden met het ontwikkelen van geneesmiddelen binnen de academische wereld, ook wel Academic Pharma genoemd.
-
Universiteit Leiden tekent strategische samenwerking met Asian Development Bank
De Universiteit Leiden gaat een strategische samenwerking aan met de regionale ontwikkelingsbank Asian Development Bank. Voorzitter van het College van Bestuur Annetje Ottow ondertekende op 27 april in Manilla de intentieverklaring voor deze unieke samenwerking.
-
Engineering of antigen-saving dissolving microneedles for intradermal vaccine delivery
The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.
-
Microneedle-mediated vaccine delivery
Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot
-
Glucocorticoid modulation of the immune response
Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.
-
Discovery of FLT3 inhibitors for the treatment of acute myeloid leukemia
The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.
-
Discovery of BUB1 kinase inhibitors for the treatment of cancer
The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.
-
Upconverting nanovesicles for the activation of ruthenium anti-cancer prodrugs with red light
Promotor: E. Bouwman, Co-promotor: S. Bonnet
-
Formative Assessments and Teacher Professional Learning
Hoe kan formatieve assessment worden ingezet om het leren van docenten te bevorderen? Dit boek bevat diverse onderzoeken naar professionaliseringsaanpakken en cursussen waarin formatieve assessment wordt aangewend met het oog op het leren van docenten.
-
Assistant Professor in Protein Design
Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)
-
Fluorescence Polarization Activity-Based Protein Profiling on Retaining Glycosidases
Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.
-
Derde jaarlijkse ‘Law and Development Research Network’-conferentie 19 t/m 21 september 2018
Van 19 t/m 21 september werd de derde jaarlijkse ‘Law and Development Research Network’-conferentie gehouden in het Museum Volkenkunde in Leiden.
-
Roxanne Kieltyka
Wiskunde en Natuurwetenschappen
-
Mario van der Stelt
Wiskunde en Natuurwetenschappen
-
Systems pharmacology of the endocannabinoid system
In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).
-
The good? The bad? The mutant! Characterization of cancer-related somatic mutations and identification of a selectivity hotspot in adenosine
G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.
-
Selective autophagy in host defense against mycobacterial infection
The effective treatment of tuberculosis (TB) remains a major challenge to global health.
-
Bioengineering and biophysics of viral hemorrhagic fever
Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…
-
Annetje Ottow in diverse media over de samenwerking met Asian Development Bank
De Universiteit Leiden gaat als eerste universiteit in Europa samenwerken met de Asian Development Bank (ADB). De Aziatische ontwikkelingsbank wil meer een 'klimaatbank' worden, Leiden gaat daarbij helpen met onderzoek en onderwijs.
-
Partners
Ons onderzoeksprogramma werkt samen met allerlei partners om ons doel, het zo snel mogelijk naar de kliniek brengen van wetenschappelijke ontdekkingen, te bereiken.
- Drugs & geschiedenis
- Drugs & medicijnen
- Drugs & biologie
-
Discovery of novel inhibitors to investigate diacylglycerol lipases and α/β hydrolase domain 16A
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
-
Stewart McDowall
Wiskunde en Natuurwetenschappen
-
Kees Musters
Wiskunde en Natuurwetenschappen
-
Novel pharmacometric techniques to quantify the pharmacodynamics of analgesics
The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.
-
Samenwerken voor efficiënte medicijnontwikkeling
De keten die patiënten voorziet van nieuwe medicijnen, bestaat uit diverse complexe schakels: van fundamentele wetenschap, tot klinische tests, tot productie. Deze hele keten is aanwezig in Leiden. De Universiteit Leiden, het Leids Universitair Medisch Centrum (LUMC) en de bedrijven op het Leiden Bio…
-
Surya Tjandra verdedigt zijn proefschrift ‘Labour Law and Development in Indonesia’ op 4 februari 2016
In zijn proefschrift beschrijft hij de ontwikkeling van het arbeidsrecht in Indonesië. De nadruk ligt op de modernisering van het arbeidsrecht in de periode na de val van het Soeharto-regime in 1998, de reformasi.
-
To explore the drug space smarter: Artificial intelligence in drug design for G protein-coupled receptors
Promotie
-
Corpora Non Agunt Nisi Fixata: Ligand Receptor Binding Kinetics in G Protein-Coupled Receptors
The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.
-
Preclinical validation of putative targets in cardiovascular and metabolic disease
Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.
- Drugs & kunst/literatuur
-
Shaping the pharmacokinetic landscape for renally cleared antibiotics in obesity
The prevalence of obesity (BMI >40 kg/m2) has increased rapidly over the recent years, not only in adults, but also in children and adolescents.
-
Small changes for long term impact: optimization of structure kinetic properties: a case of CCR2 antagonists
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman
-
Inhibitor Selectivity: Profiling and Prediction
Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.
-
In vitro and in vivo delivery of functionalized nanoparticles via coiled-coil interactions
Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn
-
Mesoporous silica nanoparticle-based protein delivery systems for biomedical applications
Promotor: A. Kros
-
Targeting the adenosinergic system
Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).
-
Studies on molecular basics of metabolic syndrome in zebrafish
The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.
-
Regulation of actomyosin contraction as a driving force of invasive lobular breast cancer
In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).
-
Diego Barbosa Arize Santos
Faculteit der Sociale Wetenschappen
-
Concepts and applications for evidence-based dosing in morbidly obese patients before and after weight loss surgery
Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst
-
Dosing considerations for preterm neonates: from pharmacometrics to clinical practice
Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.
-
Coiled-coil biomaterials for biological applications
This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.
-
2012
LIBC PUBLIEKSDAG 'DRUGS & THE BRAIN' (in Dutch)
-
Illuminating N-acylethanolamine biosynthesis with new chemical tools
In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.
-
In vivo modelling of Ewing sarcoma in zebrafish
Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska