Op het gebied van kosmologie zoeken we naar wetenschappelijke antwoorden op de meest fundamentele vragen die men kan stellen. Waar komen we vandaan? Hoe begon het heelal? Hoe heeft het zich ontwikkeld en hoe zal het eruitzien in de toekomst?

This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.

Promotor: A. Achúcarro, Co-Promotor: J.W. van Holten

Lezing, Oort lecture

Promotor: Roeland M.H. Merks

LUMC Technology Focus Area (TFA) Data Analytics is een samenwerkingsverband van verschillende onderzoeksgroepen in het LUMC die nieuwe kwantitatieve en computationele methodologie ontwikkelen voor biomedisch en klinisch onderzoek.

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)

Cursus, Summer School

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

The Minor Computational Approaches to Disease, Signaling and Drug Targets (CADSDT) is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs.

In the current global context, there is a pressing need to address sustainable energy supplies to safeguard our Planet and its ecosystems. The choices made by human society have a significant impact on genetic evolution and climate.

Promotor: Prof.dr. J.N. Kok

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.

In this work we describe three methods to improve the performance of Quantum Field Theory calculations.

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

Most of current public-key cryptography is considered insecure against attacks from sufficiently powerful quantum computers. Post-quantum cryptography studies methods to secure information resistant against such attacks. One proposal is isogeny-based cryptography, which bases its security on computational…

Assessing the risks of engineered nanomaterials (ENMs) solely on the basis of experimental assays is time-consuming, resource intensive, and constrained by ethical considerations (such as the principles of the 3Rs of animal testing). The adoption of computational toxicology in this field is a high p…

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

In this thesis, we consider various (electro)chemical phenomena at surfaces and nanoparticles and their underlying atomistic processes, which we studied using first-principles methods such as density functional theory.

Improvements of weak gravitational lensing shape measurements are presented and some used for data analysis.

Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.

Promotor: A. Achúcarro, Co-Promotor: G.A. Palma

In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.

This thesis systematically studies the physicochemical properties of non-planar, propeller-shaped, polycyclic aromatic hydrocarbons. The synthesis of several so-called propellerenes is described on a gram scale, using optimized procedures aimed at using less hazardous reagents and reducing the amount…

The theoretical explanation of cosmic acceleration is nowadays one of the biggest puzzles in cosmology.

Promotor: Prof.dr. H.V.J. Linnartz

De Leidse masterstudent Arend Moerman heeft een tien gekregen voor zijn afstudeeronderzoek naar de simulatie van de chaotische interacties van drie zwarte gaten. Uit de simulaties blijkt dat lichtere zwarte gaten elkaar meestal wegslingeren, terwijl zwaardere vooral samensmelten. Het onderzoek, een…

Promotor: K. Kuijken, Co-Promotor: H. Hoekstra

Hoogleraar Fons Verbeek, verbonden aan de informatica- en biologie-instituten van de Universiteit Leiden, heeft de fascinatie om alles wat we niet direct kunnen zien, toch in beeld te brengen. Op SleutelstadFM vertelt hij dat door het omrekenen van 2 dimensionale (2D) beelden naar 3 dimensionale (3D)…

Promotor: J. Schaye

At the moment, over 350.000 chemicals are registered worldwide for production and use. Their application, however, may harm human health and the environment.

Nu het steeds beter lukt om de moleculaire gegevens van cellen en weefsels te ontsluiten, schept dat ook direct een nieuwe uitdaging. Want hoe vind je uit die enorme hoeveelheid data de juiste informatie voor onderzoek?

We explored the Universe using weak gravitational lensing, a phenomenon that occurs when light from distant galaxies is bent by the gravitational fields of closer cosmic objects, much like how a lens distorts light.

The thesis explores how interstellar chemistry evolves as a function of time and changing physical architectures during the formation of stars.

This thesis is about cosmological inflation and its relation to observations.

Het Leiden Institute of Advanced Computer Science feliciteert alumnus Pepijn van Heiningen en de met de Technische Hochschule Köln gedeelde promovenda Samineh Bagheri. Allebei wonnen ze afgelopen week op het SSCI 2016 congres over computational intelligence in Athene een award voor de hoge kwaliteit…

Promotor: A. Achúcarro Co-promotor: A. Boyarsky

The focus of the dissertation

At the largest scales, two ingredients dictate the distribution of matter in the Universe. The first is dark matter, acting as an invisible scaffolding held together by gravitational forces.

We study the interplay of topology and geometry with chirality for several passive and active systems, employing both analytical and numerical methods.

The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…

Of all the mass in our Universe, 80% is thought to consist of a hypothetical and invisible substance called dark matter (DM).

Galaxy intrinsic alignments induce a major astrophysical contamination to weak gravitational lensing measurements and need to be modelled and mitigated when extracting cosmological information from such measurements.

Promotor: S.J. Edixhoven, L.D.J. Taelman

The ultimate goal of cosmologists is to find a cosmological model able to explain the current observational data.