Wiskunde en Natuurwetenschappen, Leiden Institute of Advanced Computer Science (LIACS)

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OB associations are loose groups of young, massive stars. They constitute the last stage of the massive starformation process, and the context in which new stars are formed.

At the moment, over 350.000 chemicals are registered worldwide for production and use. Their application, however, may harm human health and the environment.

Op 19 mei 2020 verdedigde Xuechan Ma haar proefschrift 'Moving towards Coexistence and Cooperation: The Spratly Islands and International Law'. Het promotieonderzoek is begeleid door promotor prof.dr. N.J. Schrijver.

Alumni-activiteit, Lezing

Ferritin is a spherical metalloprotein, capable of storing and releasing iron in a controllable way. It is composed of a protein shell of about 12 nm and within its cavity, iron is stored in a mineral form.

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

The thesis describes experimental steps towards reduction of friction on the macroscopic scale by scenarios of thermo- and superlubricity well-known on the nanoscale.

In this thesis we use Josephson and noise scanning tunneling microscopy for the study of conventional, unconventional (iron-based) and disordered superconductors. On the one hand, Josephson scanning tunneling microscopy allows us to directly visualize the superfluid density with high spatial resolut…

Promotor: E. Gittenberger, Co-promotores: B.W. Hoeksema; L.P. van Ofwegen

Huub de Groot

What is the best way to combine the environmental and economic data and how can we create an operational system to do so, thereby supporting the delivery of data to the Data centres on Products and Resources?

Creating information portals for support of European environmental policy.

Why do black holes emit thermal radiation? And how does a closed quantum system thermalize?

Deze opleiding is gericht op de ontwikkeling van computermodellen die de werking van medicijnen voorspellen, het individualiseren van bestaande behandeltherapieën en het ontwikkelen van innovatieve, analytische tools voor het personaliseren van de gezondheidszorg.

In deze opleiding ontwikkel je je onderzoek skills en verbreed je je kennis over de meest moderne en geavanceerde technieken die je nodig hebt als onderzoeker op het gebied van target finding en het ontwerp en de synthese van nieuwe geneesmiddelen.

Volgens het onderzoek van de auteurs wordt verwacht dat nauwkeurigheid verbetert in minder complexe programma's, maar afneemt bij toenemende complexiteit.

Natural resources often stretch across borders that separate modern nation states. This can create conflict and limit opportunities for regulated consumption of their goods and services, but also provide opportunities for joint multinational efforts that exceed single country capabilities.

Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

Wiskunde en Natuurwetenschappen, Instituut Biologie Leiden (IBL), Leiden Academic Centre for Drug Research (LACDR)

In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.

Cardiovascular disease is the leading cause of death worldwide.

The interest of this thesis lies in spin transport in normal metals and superconducting half-metallic junctions.

Latent variable modeling of students' solution strategies and performance

Promotor: Prof.dr. E. F. van Dishoeck

Multiple stars, that is two or more stars composing a gravitationally bound system, are common in the universe.

Promotor: C.J. ten Cate

The applications of studying the early development of insects range from agriculture to material science.

Het Institute of Security and Global Affairs (ISGA) opereert binnen de internationaal georiënteerde wetenschappelijke richting security studies en houdt zich bezig met multidisciplinair onderzoek en onderwijs.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Diverse types of exoplanets such as gas giants on close-in orbits (hot Jupiters) and young massive giants on wide orbits (super Jupiters), with no analogs in the Solar System, pose challenges but also opportunities to our understanding of planet formation and evolution.

Het doel van deze faciliteit is om het biomedisch onderzoek te versnellen door toegang te bieden tot geavanceerde licht- en elektronenmicroscopie en door het delen van expertise over monstervoorbereiding, beeldvormingsmodaliteiten, gegevensopslag en beeldanalyse.

Deelproject van

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

In-use stocks of products can be considered as intermediaries between human needs and the physical world.

Organic molecules in interstellar space are important as they influence the structure of galaxies and star formations. Studying catalytic processes in space allows us to understand how molecular species are formed and chemically evolved in the interstellar medium and solar system objects.

Deze masterspecialisatie leert je veelvoorkomende leerproblemen herkennen en behandelen.

In de onderzoeksmaster Hebrew and Aramaic Studies (research) van de Universiteit Leiden is gericht op het bestuderen van de Hebreeuwse en Aramese taal en cultuur in de ruimste zin.

In this thesis we study bistable reaction-diffusion equations on lattice domains.

This dissertation is about Bayesian learning from data. How can humans and computers learn from data?

Promotor: Prof.dr. T. Schmidt

We study the interplay of topology and geometry with chirality for several passive and active systems, employing both analytical and numerical methods.

This thesis is an experimental study of the UV irradiation of the interstellar ice analogues, relevant for the different stages of the star and planet formation sequence.

Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

Promotores: Prof.dr. G.A. van der Marel, M. van Heel

How should jurisdictions, both on the national and on the supra-national level, handle the interaction between public and private law where it regards the regulation of financial markets?