A combination of two potential drugs gives hope of a 'super blockage' of an over-active immune system, Leiden researchers report in Nature. The breakthrough came from the crystallisation of a membrane protein.

Can drug screening for tuberculosis treatment be made more efficient?

National Meat Free Week (Nationale Week Zonder Vlees, 7–13 March) is an initiative to reduce meat consumption. Assistant professor Paul Behrens is studying what impact a change in our food consumption would have on the world. What, according to him, are the main reasons to switch to a (mainly) plant-based…

General Assembly

IBL-researcher Phil Elks in the group of Annemarie Meijer won the Cell Observatory Publication of the Year 2013. He received the award for his paper in PLoS Pathogens, showing that activation of hypoxia signaling protects against mycobacterial infection.

Kitesurfing, colonising the Binnenhof and most important of all - meeting fellow students. More then 700 students of Leiden University in The Hague get to know the city and one another during the HOPweek.

When internist Christian Blank made his very first discovery, his field of immunotherapy was the underdog of cancer research. Now, over 20 years later, Blank has been appointed Professor By Special Appointment of Internal Medicine for his clinical research into immunotherapy and will give his inaugural…

With his essay 'Why science?', mathematics prodigy Lars Pos (18) won the Robbert Dijkgraaf Essay Prize. Within the theme 'The fascinating workings of science', the bachelor student wrote a plea for the societal value of fundamental scientific research. 'Because you don’t know beforehand where we can…

The mission in this division, headed by Laura Heitman, is to design and synthesize novel and better ligands for drug targets. Drug discovery is a lengthy but inspiring adventure. It is often an interplay between academic institutes and pharmaceutical industry, in which scientists at university develop…

Since 1 November 2022, Brechtje Paijmans is endowed professor of Conflict Resolution and Legal Protection in Education. Dutch trade journal Mr. interviewed her about her appointment.

The Novel chemical modalities research group is headed by Assistant Professor Sebastian Pomplun. Sebastian started at the division of Medicinal Chemistry within the LACDR in September 2021. His lab develops technologies for the discovery of novel chemical modalities that can address challenging drug…

Drug Discovery and Safety consists of 120 European Credit Transfer System (EC) points.

This year a record number of students - more than 3,500 - will be taking part in the EL CID introduction week. Who are they and why did they opt for Leiden University? 'I want to get the absolute most out of my student time.'

Using E. coli bacteria to convert a toxic compound in the soil on Mars into oxygen to make life on the planet possible. A team of thirteen Leiden students are taking part in the annual iGEM competition with an entry based on this idea. iGEM is an international competition for students where they use…

Former dean and physicist Frans Saris writes in his new book ‘Darwin’s combination lock’ how our culture enabled us to dominate nature and about the corresponding responsibilities. Together with Joris Berkhout he will talk about his book during the This Week’s Discoveries on 27 February.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman

On Friday March 12 2021.

The Datini Institute has launched a call for research papers for its 54th Study Week (14-18 May 2023). Deadline for submission: 10 April 2022.

Not all students who are thinking of doing a master’s programme at Leiden University can come to the Master’s Open Day. Hence the first Webinar Week, from 2 to 5 December. ‘Online video is the way to reach today’s generation of prospective master’s students.’

Warm Sweater Day, February 7th & Week of Sustainability, February 10th-14th

Promotor: M. Ubbink, Co-promotor: G. Siegal

Knowledge is everywhere at Leiden University. It is also accessible for those who do not study or work at the University.

Vera Meester has won the annual Physics Image Award 2016, with her photo of 'smiling' colloids. The Volkskrant published the picture as Image of the Week.

For many a first-year, student life has well and truly begun. This also applies to students in The Hague, who were thrown in at the deep end during the HOP introduction week. We paid them a visit on a sunny afternoon at Landgoed Clingendael.

In the Master’s programme in Bio-Pharmaceutical Sciences of Leiden University you are trained for a scientific career in drug research and development.

It was Leiden University Academy Week from 11 to 15 March. With over 300 sign-ups and a programme with 14 different webinars and workshops on our courses for professions, this edition was once again a resounding success.

Lecture

At the Leiden Curious Minds Centre, our research focuses on the relationship of exploratory behaviour and discovery learning to curiosity and the way children regulate their behaviour and emotions. We want to improve our understanding of how children can and do become more and more the captain of their…

For the annual Week of Classics, Dr Marike van Aerde and her team made a documentary about their research project Routes of Exchange, Roots of Connectivity. In the film the team touches upon the interactions of Greeks and Romans with the wider ancient world, ranging from the African kingdom of Aksum…

This thesis discusses the discovery potential of Intensity Frontier experiments.

Lecture

Immediately connect with the needs of industry with your master’s degree. The new course Practical Aspects of Quality Management in Pharma and Biotech provides just that. The LACDR and LUMC set up the course together with the Biotech Training Facility, located at the Leiden Bio Science Park. The first…

Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

Promotor: A.P. IJzerman

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.

The European Lead Factory has been created with the ultimate goal to develop lead drug candidates to address neglected diseases including bacterial infections, psychiatric disorders and oncology.

Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

Astronomers have discovered seven Earth-like planets around a dwarf star in our galaxy. Three of these planets are located in the habitable zone of this star, and may contain liquid water. ‘The next step is to study the atmospheres for signs of life. In Leiden we are experts in that area,‘ says planetary…

Chronic pain, nausea or vomiting due to chemotherapy. If you suffer from such ailments, medicinal cannabis can be a godsend. Though a downside is that it can make patients high. Therefore, Leiden researchers from the Oncode Institute are investigating alternatives that do not make you high. In Nature…

Researchers at LED3 are working together with biopharmaceutical company Galapagos to develop software for use in early drug discovery (funded by NWO). This software is able to design molecules with several simultaneously optimized characteristics and will also take prediction reliability into consideration…

Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…

In CCLS several subgroups have formed, below you can find an overview of these groups with the names of the leading researchers and a short outline of the project.

In this research group, headed by Laura Heitman, novel receptor concepts in drug discovery are studied, aiming to increase the effectivity of medicines. Many drugs act via so-called G protein-coupled receptors (GPCRs) and therefore our research is mainly focused on understanding and improving drug-receptor…

The research within the Division of Cell Systems and Drug Safety, headed by Prof. Bob van de Water, is focused on novel therapeutic modalities and novel concepts in early drug discovery, in order to develop more effective and safer therapeutic strategies. We generate advanced cell and computational…