Target selectivity is an important aspect of any drug molecule, and certainly a parameter to be optimized. That is not trivial for a number of reasons. First of all hundreds of drug targets (receptors, enzymes, ion channels) exist, and no single lab in the world has assays for all of them.

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Exchange selecting courses and projects

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Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

This thesis describes the importance of being able to control the selectivity of potential drug candidates.

Diacylglycerol lipases (DAGLα and DAGLβ) are responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the brain and peripheral tissues. Selective DAGLβ inhibitors have been proposed as a potential treatment for inflammatory diseases with reduced potential for central…

Transition metals play an essential role in biological systems, where approximately one-third of all proteins depend on a metal cofactor to perform their function.

The glycosylation reaction is a pivotal reaction in creating new and complex oligosaccharides.

Sustainable energy from wind and solar is most readily available near the sea.

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

How can the legal and socio-legal research skills of Indonesian jurists be increased in order to promote legal certainty and to strengthen the capacity of the judicial training in the country?

A Selection of the Poems of Sir Constantijn Huygens (1596-1687) was published in July 2015, edited and translated by Adriaan van der Weel and Peter Davidson.

The thesis describes the development, synthesis and biological evaluation of several proteasome inhibitor designs. Mainly, this work focusses on designing proteasome inhibitors that selectively inhibit the immunoproteasome, while leaving the constitutive proteasome mostly, if not completely, untouch…

This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.

This thesis focused on the exploration of monolayer graphene as a membrane in direct methanol fuel cell (DMFC) applications, with improvements achieved through plasma exposure or damage- free chemical functionalization.

Quantum hardware comes with a different computing paradigm and new ways to tackle applications. Much effort has to be put into understanding how to leverage this technology to give real-world advantages in areas of interest for industries such as combinatorial optimization or machine learning.

Hydrogen peroxide (H2O2) generation via electrochemical oxygen reduction is a sustainable production method for this bulk chemical. However, the selectivity of molecular catalysts for electrochemical H2O2 generation has hardly been investigated in a systematic manner, and it is unknown if their stability…

Source: Org Biomol Chem, Volume 13, Issue 8, pp. 2407-22 (2015)

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

This dissertation focuses on the overt marking of φ features encoded on perfective active auxiliaries in a group of Southern Italian dialects.

Both Europe and Latin America face challenges globally and at home. Conflicts over land and resources have been resurgent in recent years.

EUniWell –the European University for Well-Being in which Leiden University and six other universities collaborate – is among the consortia selected for funding in the ‘European Universities Initiative’. The alliance will receive funding of 5 million euros from the European Commission.

Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…

In September 2023 Social Justice Research, a journal from Springer Nature, published a ‘Special Issue on Veteran Reflections’. Eight ‘veterans’ analysed the current status of justice research and suggested new directions and refinements. Herman Steensma, guest member of the section Social, Economic…

Design and synthesis of two 3-substituted swainsonine derivatives with the aim to improve the potency and selectivity towards Golgi alpha-mannosidase II.

Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

The path to rational drug and dose selection

How do parliamentarians secure their political future? Are their activities in the legislature connected to their place on the candidate list from one election to the next? Political scientists Tom Louwerse and Cynthia van Vonno examine the Dutch case. Their main finding is that speaking in the plenary…

Yi Kyubo (1168–1241) was the foremost writer and poet of the Koryŏ dynasty (918–1392). Not Everything Unfolds as Anticipated is a miscellany of work from his Tongguk Yi Sangguk chip, a collection containing more than two thousand texts and considered the earliest substantial oeuvre of a Koryŏ writer…

On 14 and 15 March, students can register as candidates for a place in the University Council (UR) or one of the faculty councils. But what do these participation bodies do? UR member Femke van der Meulen takes us through the agenda for the next meeting.

The explosive radiation and diversification of the advanced snakes (superfamily Colubroidea) was associated with changes in all aspects of the shared venom system. Morphological changes included the partitioning of the mixed ancestral glands into two discrete glands devoted for production of venom ormucous…

The OHBM Program Committee selected LUCL's Olga Kepinska to receive a Merit Abstract Award for the 2016 OHBM Annual Meeting in Geneva, Switzerland.