263 search results for “elizabeth shared” in the Public website
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Elizabeth BuimerSocial & Behavioural Sciences
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Elizabeth BettlesFaculty of Humanities
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Elizabeth Stuart, Queen of Hearts
Elizabeth Stuart is one the most misrepresented – and underestimated – figures of the seventeenth century. Daughter of James VI & I, she was married to Frederick V, Elector Palatine in 1613 – they were crowned King and Queen of Bohemia in 1619, only to be deposed and exiled to the Dutch Republic in…
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Elizabeth den BoerFaculty of Humanities
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Elizabeth Rodriguez EstradaFaculty of Archaeology
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Emily Elizabeth GdulaSocial & Behavioural Sciences
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Elizabeth den HartogFaculty of Humanities
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Elizabeth (Liesbeth) de LangeFaculty of Science
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Spycraft: Tricks and Tools of the Dangerous Trade from Elizabeth I to the Restoration
Shining a light on the nefarious netherworlds of espionage, this is the first book to concentrate on the actual techniques and technologies used by early modern spies —from ciphers to counterfeiting, invisible inks to assassination
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Dr. Elizabeth de Lange awarded as AAPS Fellow
The American Association of Pharmaceutical Scientists (AAPS) has been pleased to announce Dr. Elizabeth de Lange as a recipient of the 2013 AAPS Fellows Award at the 2013 AAPS Annual Meeting and Exposition in San Antonio.
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Pharmacologist Elizabeth de Lange receives Honorary Doctorate in Pharmacy from Uppsala University
Professor of Predictive Pharmacology Elizabeth de Lange has received an Honorary Doctorate from the Faculty of Pharmacy of Uppsala University. She will be honoured during the Uppsala Winter Conferment Ceremony on 31 January 2020.
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Jinhui ZhouFaculty of Science
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The LeiCNS-PK3.0 model development and applications: healthy-to-diseased CNS pharmacokinetic translation
Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…
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Predictive pharmacology
The aim of this research area is to be able to predict human drug response on the basis of mathematical models that are developed using preclinical experiments and prior knowledge.
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Mechanistic modelling of drug target binding kinetics as determinant of the time course of drug action in vivo
Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.
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Prediction of human gut (colon cancer) target site concentrations and PKPD relationships
The advanced insights obtained for the CNS PBPK model development are currently used to develop advanced mathematical models for drug distribution prediction in other body tissues protected by barriers, such as the gut. The gut PBPK model will be linked to drug effects for treatment of colon cancer.
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Advancing the LeiCNS-PK3.0 model for prediction of CNS Pharmacokinetics Nonlinear BBB Transport, Inter-species Scaling, and Machine Learning
This thesis focuses on enhancing predictions of central nervous system drug exposure using the LeiCNS-PK3.0, a physiologically based pharmacokinetic model.
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Migration and Membership Regimes in Global and Historical Perspective | Studies in Global Migration History, Volume: 13/2
In Migration and Membership Regimes editors Ulbe Bosma, Gijs Kessler and Leo Lucassen bring together ten essays in an analytical framework which looks beyond the Transatlantic migration of the nineteenth and twentieth centuries in a deliberate attempt to incorporate the experience of earlier periods…
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Spatial (3-D) CNS drug distribution in vivo
Another research line is the development of a spatial CNS drug distribution model, by ultimately including the 3-dimensional anatomical organization of the CNS.
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Anne StiggelboutFaculteit Geneeskunde
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Magnificence in the Seventeenth Century: Performing Splendour in Catholic and Protestant Contexts
This new volume, published 19 November 2020, - within the series 'Intersections' -, explores the concept of magnificence as a social construction in seventeenth-century Europe. Although this period is often described as the ‘Age of Magnificence’, thus far no attempts have been made to investigate how…
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Prediction of brain target site concentrations on the basis of CSF PK: impact of mechanisms of blood-to-brain transport and within brain distribution
Promotor: Prof.dr. M. Danhof, Co-promotor: E.C.M. de Lange
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Systems pharmacokinetic models to the prediction of local CNS drug concentrations in human
Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.
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Predicting early Alzheimer's disease stage in human
A new research line is the development of liquid biopsy fingerprints to predict early Alzheimer’s disease (AD) stage in human in readily accessible body fluids in human (in collaboration with: Dr. Geert-Jan Groeneveld, CHDR; Prof. Elga de Vries, Free University Medical Center; and others).
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24-hour rhythms in drug exposure and effect
Although rarely considered by the pharmaceutical industry or clinicians, 24-hour rhythms in physiology are a factor of potential influence on the pharmacokinetics and pharmacodynamics of drugs.
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Prediction of spatial-temporal brain drug distribution with a novel mathematical model
A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.
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Predictive Pharmacology
Prof. Elizabeth de Lange is concerned with the allocation of resources for the conduct of science towards the goal of best serving the public interest. Also, while she underscores that there is still the need for using animals in drug research, she is concerned about this use, and advocates the use…
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Medieval and Early Modern Studies (c. 600-1800)
This research cluster explores processes of cultural creation, reception and transformation within a wide range of societal contexts from the early Middle Ages until c. 1800.
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The mystical kiss of the mouth. The role of images and imagery in medieval spirituality (1100-1500)
How can the importance of the image in late medieval spirituality be understood in the context of the love mysticism inspired by the imagery of the Song of Songs?
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The Skandapurāṇa Project
Uniting an international consortium of scholars, the Skandapurāṇa Project comprises a team of researchers working in fields across the Humanities. We are creating a critical edition of a foundational work of purāṇic literature and, in doing so, tracing the dynamics of a textual tradition to better understand…
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Pharmacometabolomics; prediction of system-wide multi-biomarker drug response
The lack of success of new CNS drugs in clinical development is in part due to the complexity of the CNS, unexpected side effects, difficulties for drugs to penetrate the brain, but also by the lack of biomarkers.
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Joyce Devilee-van LeeuwenAdministrative Shared Service Centre
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Karin van der HorstAdministrative Shared Service Centre
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Pieter TaamAdministrative Shared Service Centre
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Ellen de Roo-van der VisAdministrative Shared Service Centre
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Marjolein Smits-RörschAdministrative Shared Service Centre
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Willem KrassenburgAdministrative Shared Service Centre
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Corrina KlinkAdministrative Shared Service Centre
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Maurice BeckAdministrative Shared Service Centre
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Hans KuipersAdministrative Shared Service Centre
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Roos VlaskampAdministrative Shared Service Centre
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Arjan van RijnAdministrative Shared Service Centre
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Paddy Splinter-van KleefAdministrative Shared Service Centre
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Kitty BlomAdministrative Shared Service Centre
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Karin van KlaverenAdministrative Shared Service Centre
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Territoriality and choreography in site-situated performance
The research project examines the site-specific event within the field of installation art and choreographic practices.
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Organisation
The Institute of Cultural Anthropology and Development Sociology is one of five research institutes of the Faculty of Social and Behavioural Sciences. The Institute is dedicated to high-quality, interdisciplinary education and research concerning culture and development.
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