Cathodic corrosion is a relatively unknown phenomenon that can severely etch metallic electrodes at cathodic (negative) potentials.

This thesis describes the use of a combined approach of computational and experimental techniques to gain novel insights to understand the glycosylation reaction and its reactive intermediates.

Cathodic corrosion for producing nanoparticles was (re)discovered when trying to control the electrochemical etching of a scanning tunneling microscopy (STM) tip.

For effective cancer immunotherapy by vaccination, co-delivery of tumour antigens and adjuvants to dendritic cells and subsequent activation of antigen-specific cytotoxic T cells (CTLs) is crucial. In this study, a synthetic long peptide (SLP) harbouring the model CTL epitope SIINFEKL was encapsulated…

An indian stepwell on a nanoscale. That is what postdoc Nakkiran Arulmozhi calls the pattern he saw when he corroded a special kind of platinum crystal. The unique images show the destructiveness of the process, but also show how predictable it is.

In this book liposomes are explored as delivery system for allergen-specific immunotherapy. Both cationic and anionic formulations are prepared with Bet v 1, one of the allergens in birch pollen.

This work describes several studies into the electroreduction of carbon dioxide (CO2RR), both regarding mechanistical aspects and catalyst stability considerations. Mechanistic insights into carbon-carbon bond formation on a silver catalyst are described in Ch 2, were we find an acetaldehyde-like surface…

Promotores: Wim Jiskoot; Ferry Ossendorp

Promotor: Prof.dr. W. Jiskoot, Co-promotor: A. Kros

In this thesis, we consider various (electro)chemical phenomena at surfaces and nanoparticles and their underlying atomistic processes, which we studied using first-principles methods such as density functional theory.

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

Tuberculosis is a major global health problem caused by the Mycobacterium tuberculosis complex, claiming more than a million lives annually.

We aim to understand ion homeostasis in the model eukaryote S. cerevisiae.

The goal of this thesis is to understand how interfacial parameters, such as the addition of organic additives, bulk pH or metal cations of the electrolyte, affect the relevant electrocatalytic reactions, i.e. electrochemical CO2 reduction reaction or hydrogen evolution reaction.

The potential of liposomal cancer vaccines

The focus throughout this thesis will be on gathering fundamental studies of the detailed structure and composition of the electrode/electrolyte interface effect on the rate and mechanism of key electrocatalytic reactions.

Tin electrodeposition applications have rapidly evolved in the past 25 years.

Leiden University has developed a radically different method for large scale production of diverse nanoparticles and their alloys.

The role of the interfacial environment during electrochemical reactions has been increasingly valued, especially for those reactions involving protons or hydroxyl ions.

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

Key publications of the Biologics Formulation group

Electrocatalysis allows for storing electricity or converting it into chemical bonds, producing chemical building blocks and fuels using renewable resources.

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

The aromatic infrared bands (AIBs) seen throughout the interstellar medium (ISM) are generally thought to be carried by polycyclic aromatic hydrocarbons (PAHs) and their nitrogen analogues (PANHs).

Lipid nanoparticles (LNPs) have enabled the success of mRNA vaccines but remain limited in broader therapeutic use by challenges in delivery efficiency, targeting, and mechanistic understanding.

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

On 18 April, Alexandre Tavadian defended the thesis 'The International Civil Service: Redefining Its Independence'. The doctoral research was supervised by Niels Blokker and Brian McGarry.

Lecture

Promotor: E. Bouwman, Co-promotor: S. Bonnet

The aim of the project is the development of polypept(o)ide-based delivery systems to use siRNA as systemic applicated therapeutic agent against e.g. solid tumors

The central theme of Rik Mom’s research group is to identify what the electrode-electrolyte interface looks like when electrocatalysis is taking place. Using specialized forms of Raman and X-ray spectroscopy, we study the chemical state and bonding environment of the electrode surface and near-surface…

Metabolomicshas emerged as an important discipline to study molecular and cellular processes in living cells and organisms with the ultimate aim to obtain an answer to a given biological/clinical question.

The Dick Stufkens Prize 2019 for the best PhD thesis of the Holland Research School of Molecular Chemistry (HRSMC) will be awarded to Thom Hersbach. In his thesis, Hersbach presents a thorough analysis of cathodic corrosion. His comprehensive research, on which he graduated with the distinction cum…

Majuka Tanabe defended her thesis on 17 June 2015

Thomas Hansen is the recipient of the 2020 KNCV-Backer Prize for best organic chemistry thesis in the Netherlands.

The aim of ANCIENT CHARM was to develop neutron-imaging techniques and the associated equipment, and help establish neutron imaging as a mainstream archaeological analytical technique. In particular, one of the goals was a new imaging technique which called neutron resonant capture imaging combined…

If you could convert CO2 into building blocks for other molecules with the help of electricity, you could make the chemical industry considerably more sustainable. Leiden chemists have unravelled a fundamental part of this process and applied this knowledge in a real device, as they write in Nature…

Both Leon Jacobse and Thom Hersbach from Marc Koper's research group obtained their PhDs cum laude. They both investigated changes on the surface of a platinum electrode. Jacobse studied this at a positive voltage, Hersbach at a negative voltage. Platinum has the potential to convert renewable energy…

Past objects offer a wealth of information about life in earlier times. Loe Jacobs is an expert in making earthenware objects, using the same methods and means used in earlier times.

The Secular Outlook describes what moral and political secularism means. It paints the image of a world view in which state and religion are kept well separated.

Although the world has made tremendous progress in health, education, sanitation and hygiene, global public health challenges still exist. Disparities in health exist between and within nations as evidenced by inequalities in disease burden, mortality, nutrition and environmental well-being. How does…

Marie Curie once said: I have no dress except the one I wear every day. If you are going to be kind enough to give me one, please let it be practical and dark so that I can put it on afterwards to go to the laboratory.

How can rare and expensive materials be used more efficiently to produce cleaner and cheaper fuel? Under the guidance of Marc Koper, Professor of Catalysis and Surface Chemistry, international teams of scientists have published 3 articles in Nature Communications.

The "Van Marum Colloquia" are a collaborative lecture series between the LION and LIC institutes, focusing on fundamental and applied surface science.

Leiden researchers have carried out successful tests using a new method of packaging a cancer vaccine in nano-particles. The new vaccine has induced a strong immune reaction in mice. The researchers believe that this method can make an important contribution to the treatment of cancer. Their findings…

Lecture

Disinformation has become a popular subject of study and debate. A plethora of publications and policies have emerged, aiming to analyse and curb the negative consequences of unwanted communication.

Lecture

Below thesis archives will be moved shortly (work in progress) to the Leiden Repository. Once this is done, theses submitted by MI students (from 2008 onwards) can be accessed via the Repository and will be removed from this site.