A tantalizing concept that has emerged in our recent research is binding kinetics. An important parameter is residence time (RT), a direct reflection of how long a drug stays bound to its target. This parameter is of crucial importance, because drug action lasts only as long as the receptor-ligand complex…

Supervisor: Gerard van Westen

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman

Source: ChemMedChem (2015)

A next, general pharmacological problem to be tackled is how drug-target binding kinetics in vivo, affects target occupancy as an important indicator of the time-course of drug effects.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman

Supervisor: Gerard van Westen

Source: Mol Pharmacol, Volume 87, Issue 2, pp. 305-13 (2015)

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

In the emerging field of small-molecule RNA targeting, there is a growing demand for new high-throughput screening methods.

It is estimated that approximately 30% of all proteins require a metal to function. Investigating the relationship between metal-binding and peptide/protein folding allows us to uncover fundamental rules for creating metallo-peptides and proteins, which in turn leads to the creation of new structures,…

Detection of cerebral beta-amyloid (Abeta) by targeted contrast agents remains of great interest to aid the in vivo diagnosis of Alzheimer's disease (AD). Bis-styrylbenzenes have been previously reported as potential Abeta imaging agents.

For each living organism health is ensured by correct functioning of its cells. Cells therefore have elaborate methods for regulation of their proteins.

During the course of drug discovery translational steps are made.

Together with Pepijn Tuinier and Thijs Brocades Zaalberg, Sebastiaan Rietjens researched the role of trust in an international intelligence cooperation.

Leiden University is ending the experiment with the Binding Study Advice in the second year of the bachelor's programme (BSA 2) with immediate effect. Under the terms of BSA 2, students were required to obtain 90 credits within two years, including their first-year diploma.

Source: Br. J. Pharmacol., Volume 172, Issue 3, pp. 940-55 (2015)

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

De Universiteit Leiden vindt de aanpassing van het bindend studieadvies geen verstandig plan.

The Advisory Council on International Affairs (AIV) has issued an opinion on possibilities for reform within the European Union (EU) in the area of Common Foreign and Security Policy (CFSP), the EU budget, and protecting the rule of law.

Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

Intelligence scholars have been struggling to find the conditions under which international intelligence cooperation occurs. Most focus on transactional motives and guaranteed returns, the so called ‘Quid pro Quo’. At the same time, trust is often mentioned as one of the foremost conditions, yet it…

In this thesis I describe the results of Pulsed Interleaved Excitation and Fluorescence (Cross) Correlation Spectroscopy (PIE-F(C)CS) combined with single-pair Förster Resonance Energy Transfer (spFRET) used to study dynamics in single nucleosomes, which depends on subtle differences in the length of…

De asielplannen van minster Faber leveren de nodige commotie op binnen politiek Den Haag. Wilders wil geen enkele concessies doen en dreigt met verkiezingen. De Raad van State oordeelt nl. negatief op de wetsvoorstellen. Wim Voermans, zegt in Nieuwsuur dat ‘de plannen juridisch net binnen de lijntjes…

Α-synuclein, a protein associated with Parkinson’s disease, proves to bind with membranes in a surprisingly efficient way. It confirms scientists’ suspicion of the protein’s leading role in the transmission of neurotransmitters between nerve cells in the brain. Publication in PLoS ONE.

The United Nations Office for Disarmament Affairs (UNODA) has published the 2017 issue in their Civil Society and Disarmament series, titled Voluntary, Non-Binding Norms for Responsible State Behaviour in the Use of Information and Communications Technology: A Commentary. The series aims to provide…

Source: Org Biomol Chem, Volume 13, Issue 8, pp. 2407-22 (2015)

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: Dr. L.H. Heitman

On this page you will find all information about the Bachelor of Security Studies that you need as a first-year student.

Students in Leiden are entitled to good teaching and good supervision. For their part, there are some conditions they have to meet to ensure that they complete their studies within the time allotted.

This thesis seeks to investigate how cancer-associated mutations affect the pharmacological properties of selected GPCRs—primarily A2AAR and 5-HT2CR—through a combination of ligand binding assays, signaling readouts, kinetic profiling, and cellular functional assays.

Promotor: M. Ubbink, Co-promotor: G. Siegal

LUMC Technology Focus Area (TFA) Data Analytics is een samenwerkingsverband van verschillende onderzoeksgroepen in het LUMC die nieuwe kwantitatieve en computationele methodologie ontwikkelen voor biomedisch en klinisch onderzoek.

‘Huis van het Boek/Museum Meermanno in The Hague exhibits book bindings by leading Dutch Art-Nouveau artists from the period 1890-1910. The exhibition will be open from March 22 to June 23 2019. The title of the exhibition is De Bijzondere Band: Art Nouveau-boeken van Dijsselhof, Lion Cachet en Nieu…

Promotores: Prof.dr. C.A.M.J.J. van den Hondel, Prof.dr. V. Meyer (Technische Universität Berlin)

Promotor: J.P. Abrahams, Co-Promotor: N.S. Pannu

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

At Leiden University we believe it is important that you receive the right kind of support in your choice of study and while you study. This is why we use what we call the ‘Leiden study system’ to help you make a success of your study from start to finish.

A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

SMR can be used to measure the mass of adsorbed protein to nanoparticles with a high precision in the presence of free protein.

Promotor: M. Danhof, Co-promotores: J. Freijer, A. Yassen

Op deze pagina vind je antwoorden op veelgestelde vragen.

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

Biological cells, the basic building blocks of all life forms, are surrounded by a lipid membrane. More than half of the membrane is occupied by membrane proteins, which can regulate the cell functionality through specific arrangements.