In brain diseases such as Parkinson's and Alzheimer's, proteins clump together to form fibres. ‘Chaperone proteins’ unravel those fibres, but in the test tube biochemist Anne Wentink saw that this can also cause new problems. She is going to find out what happens inside cells to determine what a drug…

How do organs work in the body, and how can we create mini-organs to study diseases and test new medicines? That’s the idea behind organ-on-a-chip technology. During his PhD, Flavio Bonanini worked on developing the best possible mini-livers. ‘Make them as simple as possible, and as complex as neede…

Modified viruses can both kill cancer cells and activate the immune system. This is what an LUMC team discovered while researching a new prostate cancer therapy.

Three fundamental research projects at Leiden in physics, chemistry and medical science have received funding from the Dutch Research Council (NWO). They involve research on magnetic fields in the universe, the role of myeloid cells in cancer immunotherapy and the evolution of ancient proteins.

The winner of the 2022 Spring edition of the NWO Venture Challenge was announced during the Dutch Biotech Event. The innovative startup Iprotics has developed specific proteasome inhibitors that potentially treat multiple myeloma (MM) without the side-effects known from traditional proteasome inhibi…

Exchange: What and why?

Is it a coincidence that three chemists from the same department have each independently received a ZonMw grant? 'No,' the researchers agree in unison. 'The role of chemistry in medical biology is becoming increasingly important, and we’ve worked hard to make this happen.'

Researchers at Leiden University have created a unique model that mimics how disease develops after a dengue infection. This 'dengue-on-a-chip' model helps them study the virus more effectively. The timing is crucial, as climate change is causing dengue to spread worldwide.

Mini organs-on-chips allow us to study how diseases develop and how drugs work. Although the technology is not new, it is becoming increasingly advanced. PhD candidate Bart Kramer hopes it will eliminate animal testing in the future.

Aukje Beers combined theory and practice, as well as chemistry, biology, and computer models. In this way, she discovered two protein inhibitors during her master’s project that could contribute to the development of a new cancer drug. For her research, Beers received the Unilever Research Prize on…

What started as an idea during a social gathering led to an unexpected breakthrough in research on resistant bacteria. Biologists and chemists from Leiden developed a new substance that proves to be effective against bacteria resistant to antibiotics. They published their discovery in Nature Chemist…

Sometimes an idea seems so logical and elegant at first glance, that you later wonder why no one thought of it before. Two researchers from LACDR have teamed up to develop a completely synthetic alternative to antibodies—one that mimics their size, shape and function, but which is cheaper, more stable,…

Chemotherapy, but without hair loss or extreme fatigue. It may be possible if the toxic drug only becomes active where it is ‘switched on’ by light. Matthijs Hakkennes has helped bring that idea closer to reality and obtained his PhD cum laude. ‘I received many thank-you emails from China and Bangla…

Daniela Kraft's group has succeeded in creating a network of microparticles that is both strong and completely flexible. This may sound simple, yet they are the first in the world to succeed in doing so. A real breakthrough in soft matter physics.

The question of land property titles is a common source of conflict between indigenous communities and federal authorities all over the Americas. A new Panamanian law have led indigenous communities to reach out to archaeologist Dr Natalia Donner. A grant from the Centre for Indigenous American Studies…

One used 3D cell models to study colorectal cancer, while the other used machine learning for more efficient blood donation. For these achievements, Marieke Vinkenoog and Simon Christian Hansmann were awarded the Krijn Rietveld Memorial Innovation Award on Tuesday 2 September.

Gijs Zebregts had just graduated from International Studies when he was stricken with acute leukaemia. A stem cell donor brought relief. Now he is going to cycle from Florence to Rotterdam to raise money and awareness for the donor bank.

Nathaniel Martin, Professor of Biological chemistry, wondered what would happen if you take an antibiotic that has been known for 70 years and try to improve it with the latest tools of modern chemistry. Turns out it can become up to a hundred times more potent and prevent the growth of some drug-resistant…

Four researchers from Leiden University will receive funding from arthritis foundation ReumaNederland over the next five years. This should facilitate long-term research into arthritis.

A new treatment for atherosclerosis showed promising results in isolated cells but proved to be less effective in initial animal tests. Bachelor student Biopharmaceutical Sciences Willemijn van der Heijden aimed to understand why. She investigated whether the formation of a protein layer around the…

How do you know if a drug will actually work? The Leiden-based spin-off Omivera is developing a new technology that could provide clearer answers. The young company received a seed investment from the investment fund UNIIQ to support its development.

Leila Akkari was appointed Special Professor of Cancer-immune interactions at the Leiden Institute of Chemistry (LIC) on 15 December. Akkari is a researcher at the Netherlands Cancer Institute (NKI), where she studies the relationship between cancer cells and the immune system, with a particular focus…

Human cells are protecting their proteins from unfolding and aggregating. That's what biophysicist Alireza Mashaghi and his team discovered after seven years of in-depth research into the folding mechanisms of proteins. With an unprecedented approach, the team was able to study the folding of a single…

Why join the Honours College? Three honours students share why they chose to do something extra alongside their bachelor's degree.

Donororganen zijn er nooit genoeg. De organen die wel beschikbaar zijn, moeten vliegensvlug getransplanteerd worden. De geneeskunde zet daarom volop in op het langer goedhouden van organen. Marlon de Haan (24) onderzoekt hoe je nieren buiten het lichaam in leven kunt houden.

In donut-shaped buildings, particle accelerators take super-detailed X-ray images. Yet those images are not good enough to learn how to drive on hydrogen for example. Mathematics PhD student Allard Hendriksen has developed an algorithm that improves the images without having to learn from data from…

One discovered that arteriosclerosis resembles an autoimmune disease, while the other developed a system to aid in the search for new medications. For these achievements, Marie Depuydt and Jurren de Groot were awarded the Krijn Rietveld Memorial Innovation Award on the evening of Tuesday 4 June.

A flu virus could cause a pandemic. And then we would be poorly armed because flu viruses are starting to become resistant to flu medications like Tamiflu. Chemist Merijn Vriends successfully worked on an improved version of such medications. He will be awarded his doctorate on September 12th.

The fact that scientists are increasingly better able to access molecular cell and tissue data also brings with it a new challenge: how can scientists find the information they need for research among the vast amount of data available?

Smart drug carriers, uneven cosmic expansion, and solar energy storage in molecules. These are the topics of three newly awarded NWO-XS grants to researchers at the Faculty of Science.

An impressive 22 research projects by Leiden researchers have been awarded Veni funding from the Dutch Research Council (NWO).

Leiden researchers have found clues to why a rare pregnancy disorder is mild in some babies but life-threatening in others. Their discovery opens the door to a test that could identify severe cases during pregnancy. Fortunately, a treatment already exists.

Exceptional collaboration between physicians is needed to better understand and treat autoimmune diseases that cause inflammation in various organ systems.

What happens in the brains of people with psychiatric illnesses? With a €23.23 million gravity grant, scientists from different fields will search for biological causes over the next decade. ‘By joining forces, we hope to improve diagnosis and treatment for patients with these diseases.’

The AtheroNeth consortium received €6 million from the Dutch Heart Foundation to gain a better understanding of the differences in disease progression among patients with atherosclerosis. The ultimate goal is to enable personalised treatment.

Professor Amir Zadpoor is developing biomaterials, and engaging in 3D, 4D, and bioprinting. 'Collaboration and regular contact with clinicians serve as a sanity check for all our ideas.'

On 26 January, Rowie Stolk, Laura Hanrath and Marloes Noorloos spoke at the lecture ‘The Right to Demonstrate under Scrutiny’. This discussion session, part of the university lecture series Community. Conversation. Connection., was organised in response to difficult questions about the right to demo…

Swarms of drones, pedestrians or the cells in your body. Those are all examples of active matter: materials whose building blocks can move autonomously. That’s what Luca Giomi studies. Giomi has been appointed Professor of theoretical physics in the area of soft matter and biological physics at the…

Chemist Tobias Bauer discovered ways to improve drugs by encapsulating them. Packages with iron nanoparticles, for example, can stimulate immune cells. Bauer will receive his PhD on 9 June.

Understanding the proces of electrochemical reactions is essential to improve the technology for the energy transition. Fuel cell cars, for example use hydrogen produced from the electrolysis of water. Mariana Monteiro did fundamental research on the process and won two prizes with her thesis.

Education

Nausea, neurologic pain and hair loss: some of the severe side effects of chemotherapy. Not necessary, biochemist Liyan Zhang showed. Together with Leiden biologists and others, she achieved great results with a drug that is only active in combination with light. Zhang will defend her PhD on 4 July.

Already during their bachelor’s programme, students in Pharmaceutical Sciences are presented with challenging projects. One of these is the Bachelor Research Assignment (BOO in Dutch), which is often their first real experience with scientific research. This means a lot of responsibility and failures,…

A Dutch consortium has received €6.7 million to accelerate the development of nanomedicines together with patients. Researchers from Leiden University play a key role in the project.

internship, research project, fieldwork, summer school, conference, excursion, field trip, thesis

What are the costs involved in studying abroad and how can you finance your stay? Avoid unexpected expenses by researching financial matters thoroughly in advance.

Nienke Weijermars studied Public Administration at the Faculty of Governance and Global Affairs. While doing her bachelor’s, she enrolled in the minor in Journalism and New Media, followed by an internship at Dutch local newspaper Leidsch Dagblad: 'At Leidsch Dagblad, they really had time to teach me…