Elizabeth Stuart is one the most misrepresented – and underestimated – figures of the seventeenth century. Daughter of James VI & I, she was married to Frederick V, Elector Palatine in 1613 – they were crowned King and Queen of Bohemia in 1619, only to be deposed and exiled to the Dutch Republic in…

Shining a light on the nefarious netherworlds of espionage, this is the first book to concentrate on the actual techniques and technologies used by early modern spies —from ciphers to counterfeiting, invisible inks to assassination

The American Association of Pharmaceutical Scientists (AAPS) has been pleased to announce Dr. Elizabeth de Lange as a recipient of the 2013 AAPS Fellows Award at the 2013 AAPS Annual Meeting and Exposition in San Antonio.

Professor of Predictive Pharmacology Elizabeth de Lange has received an Honorary Doctorate from the Faculty of Pharmacy of Uppsala University. She will be honoured during the Uppsala Winter Conferment Ceremony on 31 January 2020.

Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

The aim of this research area is to be able to predict human drug response on the basis of mathematical models that are developed using preclinical experiments and prior knowledge.

The advanced insights obtained for the CNS PBPK model development are currently used to develop advanced mathematical models for drug distribution prediction in other body tissues protected by barriers, such as the gut. The gut PBPK model will be linked to drug effects for treatment of colon cancer.

This thesis focuses on enhancing predictions of central nervous system drug exposure using the LeiCNS-PK3.0, a physiologically based pharmacokinetic model.

In Migration and Membership Regimes editors Ulbe Bosma, Gijs Kessler and Leo Lucassen bring together ten essays in an analytical framework which looks beyond the Transatlantic migration of the nineteenth and twentieth centuries in a deliberate attempt to incorporate the experience of earlier periods…

Another research line is the development of a spatial CNS drug distribution model, by ultimately including the 3-dimensional anatomical organization of the CNS.

Meet the people of the Resilience Center

Arie van Steensel and Ariadne Schmidt (eds.)

Promotor: Prof.dr. M. Danhof, Co-promotor: E.C.M. de Lange

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

This new volume, published 19 November 2020, - within the series 'Intersections' -, explores the concept of magnificence as a social construction in seventeenth-century Europe. Although this period is often described as the ‘Age of Magnificence’, thus far no attempts have been made to investigate how…

A new research line is the development of liquid biopsy fingerprints to predict early Alzheimer’s disease (AD) stage in human in readily accessible body fluids in human (in collaboration with: Dr. Geert-Jan Groeneveld, CHDR; Prof. Elga de Vries, Free University Medical Center; and others).

Uniting an international consortium of scholars, the Skandapurāṇa Project comprises a team of researchers working in fields across the Humanities. We are creating a critical edition of a foundational work of purāṇic literature and, in doing so, tracing the dynamics of a textual tradition to better understand…

Although rarely considered by the pharmaceutical industry or clinicians, 24-hour rhythms in physiology are a factor of potential influence on the pharmacokinetics and pharmacodynamics of drugs.

A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

Prof. Elizabeth de Lange is concerned with the allocation of resources for the conduct of science towards the goal of best serving the public interest. Also, while she underscores that there is still the need for using animals in drug research, she is concerned about this use, and advocates the use…

This research cluster explores processes of cultural creation, reception and transformation within a wide range of societal contexts from the early Middle Ages until c. 1800.

How can the importance of the image in late medieval spirituality be understood in the context of the love mysticism inspired by the imagery of the Song of Songs?

The lack of success of new CNS drugs in clinical development is in part due to the complexity of the CNS, unexpected side effects, difficulties for drugs to penetrate the brain, but also by the lack of biomarkers.

The research project examines the site-specific event within the field of installation art and choreographic practices.

The Institute of Cultural Anthropology and Development Sociology is one of five research institutes of the Faculty of Social and Behavioural Sciences. The Institute is dedicated to high-quality, interdisciplinary education and research concerning culture and development.

A Leiden literary scholar, paintings of the Winter King and Queen and a string of pearls brought together by an exhibition in the Hague. Dr Nadine Akkerman: ‘The Winter Queen was a highly political person who used every means – including pearls - to showcase her royal lineage.’