118 search results for “anti-cancer date some” in the Public website
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Development of novel anti-cancer strategies utilizing the zebrafish xenograft model
In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…
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Upconverting nanovesicles for the activation of ruthenium anti-cancer prodrugs with red light
Promotor: E. Bouwman, Co-promotor: S. Bonnet
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Pursuing new anti-cancer therapy as a team
Cancer is the leading cause of death in the Netherlands, and, with over 100 different types of cancer, it’s not a simple disease. Today, skin, breast, lung, prostate and colon cancer are the most diagnosed forms. Therefore, the discovery and development of new drugs has the ability to significantly…
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Pulling the strings on anti-cancer immunity
Promotores: J. Jonkers, K.E. de Visser
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Anthracycline biosynthesis in Streptomyces: engineering, resistance and antimicrobial activity
Actinobacteria are well known for the production of bioactive natural products, many of which have applications in the fields of human, animal and plant health. Subject of this thesis are the anthracyclines, glycosylated aromatic polyketides with potent anticancer activity.
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Light-activatable metallodrugs and metal-functionalized liposomes
Metal-containing molecules combine geometrical features and a reactivity that are inherently different from that of organic molecules. My research focuses on light-activatable metal-based anticancer drugs and metal-functionalized liposomes. Light is a very selective way to activate photosensitive drugs…
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A pharmacognostic study of Vernonia guineensis Benth. (Asteraceae): bioactivity, safety, and phytochemical analysis
Promotor: Prof.dr. R. Verpoorte, , Co-Promotor: Young Hae Choi
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Smart chemistry rids anti-cancer drugs of serious side effects
Researchers of the Leiden University Medical Centre (LUMC) and the Leiden Institute of Chemistry have made an important discovery about the commonly used anti-cancer drug doxorubicin. They have found a way to reduce its side effects without sacrificing the effectiveness of the medication. This is encouraging…
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Refining techniques for radiocarbon dating small archaeological bone samples
Direct radiocarbon dating of human remains is crucial for the accurate interpretation of prehistory. Yet given the scarcity of prehistoric human remains, direct dating is often too destructive for important fossils. The reduction of sample size necessary for dating bone is therefore of great interest…
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Imaging of alkyne-functionalized ruthenium complexes for photoactivated chemotherapy
In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.
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Ruthenium-peptide conjugates for targeted phototherapy
As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.
- Save the date: 450-talk
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In vivo modelling of Ewing sarcoma in zebrafish
Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar-Jagalska
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Natalia DonnerFaculty of Humanities
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Chemistry research for better chemotherapy Finalist PNAS paper award
Last year, chemists Dennis Wander and Hermen Overkleeft contributed to an important discovery about a widely used cancer drug. Their research has now been recognised as Finalist for the PNAS Cozzarelli Prize in the Biomedical Sciences class.
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Master student Maddalena Centanni awarded with Arenberg-Coimbra Group Prize
Former masterstudent Bio-Pharmaceutical Sciences Maddalena Centanni will be awarded the 2020 Arenberg Coimbra Prize for Erasmus Students. Centanni spent her six month Erasmus exchange at Uppsala Universiy in Sweden where she looked for ways to improve anti-cancer drug dosing.
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Functional analysis of Dof transcription factors controlling heading date and PPDK gene expression in rice
Promotor: P.J.J. Hooykaas, Co-Promotores: P.B.F. Ouwerkerk, M. Wang
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PhD Theses
A full overview of MCBIM PhD theses.
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Joanne MolFaculty of Archaeology
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Settlement Dynamics and High-Precision 14C Dating
For present purposes, it is important to distinguish between an early period of settlement, about 6800-6200 BC, and a late period, about 6200-5800 BC, at Tell Sabi Abyad.
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Specialised immune cells have potential for new cancer immunotherapies
Researchers from Leiden University Medical Center (LUMC) and Netherlands Cancer Institute (NKI) have discovered how specialised immune cells can detect and remove cancers that are ‘invisible’ to the conventional defence mechanisms of the immune system. Their work has been published in Nature. The findings…
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Optically stimulated luminescence dating of Palaeolithic cave sites and their environmental context in the western Mediterranean
The Western Mediterranean is a key region to understand human dispersal events within and out of the African continent as well as for the eventual replacement of Neanderthals by anatomically modern humans during the Pleistocene. Central to any conclusive interpretation of archaeological and palaeoclimatic…
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Fighting cancer with light (and a drug that self-assembles into nanoparticles)
Chemotherapy that does not harm the body, but effectively fights cancer cells: that is the goal of chemist Sylvestre Bonnet and his team. During his PhD research, chemist Xuequan Zhou brought that goal a little closer. He developed molecules that, upon injection in the bloodstream, self-assemble into…
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Computational modeling of pharmacokinetics and tumor dynamics to guide anti-cancer treatment
PhD defence
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Re‐dating the seven early Chinese Christian manuscripts : Christians in Dunhuang before 1200
Mr. J. Sun defended his thesis on 21 March 2018.
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Bioorthogonal deprotection strategy to study T-cell activation and cross- presentation
Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.
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Light and nanoparticles against cancer
Leiden PhD student Xuequan Zhou has designed a new promising molecule that efficiently kills cancer cells, but does not harm healthy tissue. The trick: the drug is only active when irradiated with light. Zhou’s new compound does this extra efficiently by cleverly self-organising into nanoparticles.…
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MCBIM Colloquium: Lightning Up Platinum Complexes for Tumor-Targeted Anticancer Therapy
Lecture
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Molecular and Nano-Engineering with Iron, Ruthenium and Carbon: Hybrid structures for Sensing
Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.
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Analysis of the angucycline biosynthetic gene cluster in Streptomyces sp. QL37 and implications for lugdunomycin production
Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.
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Ecology and genomics of Actinobacteria and their specialised metabolism
Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.
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Synthetic carbohydrate ligands for immune receptors
One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.
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Molecular characterization of copper-dependent enzymes involved in Streptomyces morphology
Promotor: G.P. van Wezel, Co-promotor: D. Claessen
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Exploring and exploiting the mechanism of mycelial pellet formation by Streptomyces
Promotor: G.P. van Wezel
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Bioactive Molecules in Animal Sciences
Animal Sciences’ contribution to the Bioactive Molecules research theme includes research on molecules from natural sources, such as plants, insects, and snake venom, with the aim to identify novel anti-cancer, anti-inflammatory, anti-microbial, and anti-diabetic agents.
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Getting personal: Advancing personalized oncology through computational analysis of membrane proteins
Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.
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Towards near-infrared light-activated combination chemotherapy
The goal of the research presented in this thesis was to explore the chemical space of ruthenium(II) photocages, investigate their ability to host potent chemotherapy drugs, and to red shift the activation wavelength of the most promising PACT candidates to conduct biological studies.
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Discovery of Reversible Monoacylglycerol Lipase Inhibitors
Monoacylglycerol lipase (MAGL) is the principal enzyme responsible for hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL inhibition provides several potential therapeutic opportunities, including anti-nociceptive, anti-inflammatory and anti-cancer activity.
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Harnessing the immunostimulatory properties of oncolytic reovirus for anticancer immunotherapy
PhD defence
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Bioorthogonal Antigens as Tool for Investigation of Antigen Processing and Presentation
In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…
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Dates 'Foundations 1' available
'Foundations 1' takes place on 1-3 March. Do you want to learn more about different types of sources and methods for source analysis in the Dominican convent in Huissen? Register now by sending an email to ozsmed@hum.leidenuniv.nl!
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DNA dating at Lowlands
Why do opposites attract? According to Karin van der Tuin, researcher at Leiden University Medical Center (LUMC), it could be because of your DNA. The more you differ from one another, the better. She will be testing her ideas at the Lowlands festival Lowlands, where she will subject visitors to DNA…
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Save the date: Centre for Digital Scholarship Summer Training Week 2026
Workshops, lectures
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Bioactive Molecules in Plant Sciences
Plant Sciences' contribution to the Bioactive Molecules research theme is to identify new plant bioactive molecules, and unravel their mechanisms of action in plant development or health, and the regulatory networks and (bio)synthetic pathways required for their production.
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Research
Research at the MCBIM group is comprised of the following research themes:
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Some case studies of random walks in dynamic random environments
Promotor: Promotor: W.Th.F. den Hollander, Co-promotor: V. Sidoravicius.
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On some classes of modules and their endomorphism rings
Promotores: Prof.dr. H Lenstra, Prof.dr. A Facchini (Padova University)
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New dates for our Dutch language course
The next round of courses will take place from Monday, 26 September 2022 until Wednesday, 30 November 2022. In the upcoming course round, level 1, level 2, level 3 and level 4 will be offered. Classes will take place on Mondays and Wednesdays only.
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Save the date: Mmmonk School 2024
Mmmonk en het Henri Pirenne Instituut voor Middeleeuwse Studies (UGent) organiseren eind 2024 de tweede editie van Mmmonk School: Lessen voor gevorderde beginners rond het middeleeuwse boek. Mmmonk School biedt een interdisciplinair praktijkgericht programma over middeleeuwse Vlaamse manuscripten. Experts…
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Text-mining real-world data to evaluate systemic anti-cancer therapy
PhD defence