How can new compounds relieve cancer patients of severe side effects?

Chemotherapy that does nothing until you irradiate it with light. Sylvestre Bonnet receives a Vici grant of 1.5 million euros for the development of this treatment. The Leiden chemist wants to build a new molecule to fight tumours that are at the time still difficult to treat.

Optimization, mechanisms of action and predictors of the outcome of light therapy in depression: A multicenter randomized trial

This study stresses the importance of investigating vitamin D deficiency in every community to better understand the deteriorating effect that sociocultural practices may have had on health.

Wolfgang Lüffler

The aim of this facility is to accelerate biomedical research by providing access to advanced light and electron microscopy and by sharing expertise about sample preparation, imaging modalities, data storage and image analysis.

Promotor: H.V.J. Linnartz

On the 23rd of January, Anastasiia Ionova successfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Anastasiia on this achievement.

Promotor: Prof.dr. T.J. Aartsma, Co-promotor: R.N. Frese

This thesis describes how different colours of light affect various aspects of the growth and development of Arabidopsis and tomato plants⁠.

How can lasers control the growth of new blood vessels?

Promotor: Prof.dr. V. Icke, Co-Promotor: T.I. Madura

Polycyclic aromatic hydrocarbons (PAHs) are the most abundant class of organic compounds in space. The PAH field evolves from the constant interaction between experimentalists, theorists, modellers and observers. While laboratory research and quantum chemical calculations together set up the molecular…

Metal-containing molecules combine geometrical features and a reactivity that are inherently different from that of organic molecules. My research focuses on light-activatable metal-based anticancer drugs and metal-functionalized liposomes. Light is a very selective way to activate photosensitive drugs…

Can light-activatable ruthenium compounds be used as a more selective anticancer treatment?

This project addresses the occurrence of political and ideological biased crimes in light of the recent migration influx in European countries.

The goal of the research presented in this thesis was to explore the chemical space of ruthenium(II) photocages, investigate their ability to host potent chemotherapy drugs, and to red shift the activation wavelength of the most promising PACT candidates to conduct biological studies.

Promotor: Koen Kuijken Co-promotor: Henk Hoekstra

Rossi

What are the effects of light pollution from cities and bridges and noise pollution from passing vessels and nearby road traffic on migratory fish passage and spawning in rivers?

What is the effect of light at night on plant phenology and physiology, and how does this affect plant interactions with other species?

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

Promotor: E. Bouwman, Co-promotor: S. Bonnet

The main question of this research project concerns the extent to which light verbs in West Germanic languages participate in processes of language change.

Research in the van Exter lab focuses on quantum aspects of light and light-matter interaction. One of our long-term goals is to develop a reliable quantum memory, based on a single emitter in an open micro cavity.

A single self-assembled semiconductor quantum dot in a high-finesse optical microcavity - the subject of this thesis - is an interesting quantum-mechanical system for future quantum applications. For instance, this system allows trapping of an extra electron and thus can serve as a spin quantum memory,…

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn, Co-promotor: Dr. M.J.M. Schaaf

Light obscuration (LO) is the current standard technique for subvisible particle analysis in the quality control of parenterally administered drugs, including therapeutic proteins.

Solar energy is used by photosynthetic organisms to drive energy required cellular processes. Is absorbed by two groups of pigments, located in the LHCs.

Promotores: Prof.dr. C.U. Keller, Prof.dr. H.C. Gerritsen

In astronomy, the interpration of observations and measurements plays a crucial role: we rely purely and fundamentally on the information that reaches us as observers. And 80% of all matter in the universe is undetectable directly.

Surface acoustic waves (SAWs) are mechanical waves that travel along the surface of a material and find many applications in modern technologies due to the ease of excitation on piezoelectric substrates via interdigital transducers (IDTs).

PURPOSE: In the present study we investigated the root-cause of an interference signal (100-200 nm) of sugar-containing solutions in dynamic light scattering (DLS) and nanoparticle tracking analysis (NTA) and its consequences for the analysis of particles in biopharmaceutical drug products.

This thesis studied in depth the energy use and CO2 emissions of the industrial sector in China.

Has the industrial sector in China effectively been decarbonizing in recent years, across different regions and subsectors, and is it plausible that it will reduce its CO2 emissions in conformity with national and internationally pledged emission goals?

Leiden PhD student Xuequan Zhou has designed a new promising molecule that efficiently kills cancer cells, but does not harm healthy tissue. The trick: the drug is only active when irradiated with light. Zhou’s new compound does this extra efficiently by cleverly self-organising into nanoparticles.…

Depictions of Rembrandt, Michelangelo and many other artists are given a new dimension in an exhibition in the hall of the Oude UB at Leiden University. The exhibition - 'Multiple Images' - opens officially on 15 February. Artist Rudi Struik has given the slides of Leiden art historian Henri van de…

Physicist Martin van Exter works with light at nanoscale, at the forefront of nanocomputer research. But as Director of Education he also has a vision for physics teaching. Inaugural lecture 18 November.

From simulations of galaxies to analyses of MRI scans: scientific research needs more and more computing power. Leiden University is planning to set up a completely new facility for high-performance computing. The green light was given officially on 20 June.

This article traces the evolution of interpretations of international law and international cyber norms on responsible state behaviour in cyberspace by reassessing five major – and allegedly state-led – cyber operations: Stuxnet 2010; Belgacom 2013-2014, the Ukrainian power grid 2015, the US presidential…

An international team led by Leiden astronomers has, after years of searching and defying the boundaries of a telescope, for the first time directly captured polarised light from an exoplanet. From this light they can deduct that a disk of dust and gas orbits the exoplanet. In this disk moons are possibly…

Farmers on the outskirts of Nairobi National Park protect their livestock using flashing lights on top of the animal enclosures. This system keeps lions away at night. Leiden research has shown that the method is both simple and effective. Publication in PLOS ONE.

Physicists have manipulated light with large artificial atoms, so-called quantum dots. Before, this has only been done so well with actual atoms. It is an important step towards light-based quantum technology. Publication on August 30th in Nature Communications.

Dark matter is one of the biggest mysteries of the Universe. Its properties cannot be explained with the known laws of physics and elementary particles.

Bredero (1585-1618) was known for his farces and comedies, but he also wrote one tragedy. According to Olga van Marion and Tim Vergeer, the play's main protagonists Rodd’rick and Alphonsus were not competing for the love of a lady, but were in love with one another.

An international team of astronomers has found an unexpected link between dark matter and visible stars in stellar systems. This discovery may even cause us to reconsider our understanding of gravity. They published on their discovery in 'Nature' on 1 October.

Many astronomers suspect that most of the matter in the universe is invisible. So how can you weigh dark matter if you can't actually see it? Professor Henk Hoekstra is looking for a solution. Inaugural lecture 25 June.

Plants are able to resist a pathogen’s attack by a dual innate immune system. The relationship between the two pathways was not clear, but it turns out that they mutually potentiate each other, as assistant professor Pingtao Ding (Institute of Biology Leiden) and colleagues (The Sainsbury Laboratory,…