1,938 search results for “computer aided drug design” in the Public website
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Deep learning for visual understanding
With the dramatic growth of the image data on the web, there is an increasing demand of the algorithms capable of understanding the visual information automatically.
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Josien de Klerk
Faculty Governance and Global Affairs
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Willemien den Ouden
Faculteit Rechtsgeleerdheid
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Salvador Santino Regilme
Faculty of Humanities
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Rijk van Dijk
Afrika-Studiecentrum
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New software for designing sustainable cities
By 2050, more than 70 per cent of the world’s population will live in cities. A group of International researchers has developed software that shows city planners where to invest in nature to improve people’s lives and save billions of dollars.
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Brand-new professor Gerard van Westen wants to cross boundaries
Brand-new professor Gerard van Westen works at the intersection of artificial intelligence and drug development. For the new chair in Artificial Intelligence and Medicinal Chemistry, he uses computer models to make drug development more efficient. Our ultimate goal is a virtual human which allows you…
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Computer science research in Leiden of major relevance to society
An international committee has assessed computer science research at all Dutch universities in the period 2009-2014. For its computer science research, Leiden was awarded the ‘highest’ mark (1) for relevance to society.
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Smart chemistry rids anti-cancer drugs of serious side effects
Researchers of the Leiden University Medical Centre (LUMC) and the Leiden Institute of Chemistry have made an important discovery about the commonly used anti-cancer drug doxorubicin. They have found a way to reduce its side effects without sacrificing the effectiveness of the medication. This is encouraging…
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Bartolomeus Häussling Löwgren
Science
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Peter Berrill
Science
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Roozbeh Siyadatzadeh
Science
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Julian Steinke
Faculteit der Sociale Wetenschappen
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Dirk Visser
Faculteit Rechtsgeleerdheid
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Lina van Drunen
Faculteit der Sociale Wetenschappen
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Interfacing the past
Computer applications and quantitative methods in archaeology CAA95.
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FishForPharma: Training network on zebrafish infection models for pharmaceutical screens
How can zebrafish models be used to gain a better understanding of host-pathogen interaction mechanisms and to screen new drugs for infectious disease treatment?
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New IBL-professor in "Computational Biology": Vera van Noort
Vera van Noort has been appointed Professor in the field of Computational Biology within the Faculty of Science at the Institute of Biology from the 1st of February 2017. Van Noort’s expertise is in bioinformatics and her research focuses on the computational analysis of large-scale biological data…
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Life work award for computer scientist Grzegorz Rozenberg
Leiden prof. emeritus Grzegorz Rozenberg is honoured with the first life time award in formal languages, a research area of theoretical computer science. During a small ceremony at his house, he received a statue that was specially made for the occasion.
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Glucocorticoid modulation of the immune response
Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.
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Discovery of FLT3 inhibitors for the treatment of acute myeloid leukemia
The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.
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Skin researcher calls for multidisciplinary collaboration: ‘I want to pool expertise’
In dermatology, there should be a high level of multidisciplinary collaboration among institutes and specialists, Professor of Translational Dermatology, Robert Rissmann, will say in his inaugural lecture on 8 July. He is building an infrastructure that will put pre-clinical and clinical skin research…
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Upconverting nanovesicles for the activation of ruthenium anti-cancer prodrugs with red light
Promotor: E. Bouwman, Co-promotor: S. Bonnet
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Coen van Hasselt
Science
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Anthe Janssen
Science
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'Offer research and design processes in a varied manner'
Research and design are two activities that are becoming increasingly important in the Dutch subjects O&O (‘research and design’) and NLT ('nature, life and technology’). The dissertation of Tessa Vossen (ICLON and Faculty of Science) indicates that teachers and students understand the importance of…
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Article on Affective Computing by Andreas Häuselmann published in IDPL
Affective Computing (AC and sometimes called ‘Emotional AI’) provides opportunities to automatically process emotional data. However, is EU data protection law fit for purpose when it is applied to such AC approaches?
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Granted STW Project: Energy Efficient Computer-Brain Interaction
The STW project Energy Efficient Computer-Brain Interaction (principal investigator for LIACS: dr. T.P. Stefanov) has been granted. Funding for LIACS: 1 PhD student + travel/equipment budget, project duration: 4 years.
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Flat but not shallow. Towards flatter representations in deep semantic parsing for precise and feasible inferencing
Simulating human language understanding on the computer is a great challenge. A way to approach it is to represent natural language meanings in logic, and to use logical provers to determine what does and does not follow from a text. What logic is best to use and how natural language meanings are best…
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Call for participation: KABK Design / Research Club #2
You are warmly invited to join us for the second meeting of the KABK Design / Research Club, a forum for researchers from the KABK and Leiden University who are conducting research in, about, or through design-related disciplines.
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Alice Twemlow wins Simon Mari Pruys prize for design criticism
On Saturday November 16 Alice Twemlow was awarded the Simon Mari Pruys prize for design criticism for her essay ‘Conflicting Definitions of Key Terms’.
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Fault Lines Design/Research at KABK/Leiden University
Organized by the Lectorate Design Friday, December 14, 2018 KABK Auditorium 10:00-17:00
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Tailoring x-ray tomography techniques for cultural heritage research
Visualizing the internal structure is a crucial step in acquiring knowledge about the origin, state, and composition of cultural heritage artifacts. Among the most powerful techniques for exposing the interior of cultural heritage objects is computed tomography (CT), a technique that computationally…
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Quantitative systems pharmacology modeling of biotherapeutics in oncology
In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.
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PROPER: ‘Near-patient’ prostate cancer models for the assessment of disease prognosis and therapy
How to identify patients at risk of developing devastating, metastatic disease and facilitate the development of personalised treatment for prostate cancer patients?
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The Design of Principles and Guidelines for Out-of-Court Turnaround Professionals
In a project of INSOL Europe's Turnaround Wing, TRI Leiden is working on the design of Principles and Guidelines for Restructuring and Turnaround Professional. These Principles and Guidelines are designed for the out-of-court turnaround of a business in distress. This Report is the result of a study…
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Computational tools reveal secrets of 17th-century sealed letter
In a world first, an international team of researchers has read an unopened letter from Renaissance Europe – without breaking its seal or damaging it in any way. Nadine Akkerman, Reader in early modern English literature at Leiden University, is co-author of the article that appeared on 2 March in Nature…
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Design METIS instrument for the Extremely Large Telescope finalised
The design for the METIS instrument for the Extremely Large Telescope (ELT) is final. The European Southern Observatory (ESO) has given the green light for production of all parts of the instrument. It is the first ELT instrument, designed and to be built under Dutch leadership, to formally pass the…
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Building with algorithms: looking for the optimal design
How can computers help design optimal buildings? PhD student Koen van der Blom makes algorithms that take into account all kinds of different architectural requirements, in order to reach the best compromise. And that is quite difficult: 'Algorithms do not automatically understand that a building that…
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Fluorescence Polarization Activity-Based Protein Profiling on Retaining Glycosidases
Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.
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Systems pharmacology of the endocannabinoid system
In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).
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Jaap Reijling
Faculty Governance and Global Affairs
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The interplay between lipids and the immune system in atherosclerosis
Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.
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Exploring Images With Deep Learning for Classification, Retrieval and Synthesis
In 2018, the number of mobile phone users will reach about 4.9 billion. Assuming an average of 5 photos taken per day using the built-in cameras would result in about 9 trillion photos annually.
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Algorithm selection and configuration for Noisy Intermediate Scale Quantum methods for industrial applications
Quantum hardware comes with a different computing paradigm and new ways to tackle applications. Much effort has to be put into understanding how to leverage this technology to give real-world advantages in areas of interest for industries such as combinatorial optimization or machine learning.
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MARBLES - Marine Biodiversity as Sustainable Resource of Disease-Suppressive Microbes and Bioprotectants for Aquaculture and Crop Diseases
To explore the potential of marine microorganisms as producers of novel antimicrobial agents and as bioprotectants in aqua- and agriculture, using an integrative, ecology-based strategy for bioprospecting.
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Characterization and skin permeation of ketoprofen-loaded vesicular systems
PURPOSE: To determine the effect of elasticity on the skin permeation of ketoprofen from surfactant-based vesicular formulations and elastic liposomes.
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Sebastian Pomplun
Science
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Algebraic techniques for low communication secure protocols
Promotor: R. Cramer
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Adam Cohen receives Dr. Saal van Zwanenberg Honorary Prize
Professor of Clinical Pharmacology Adam Cohen from Leiden University received the prestigious Dr. Saal van Zwanenberg Honorary Prize on 12 November. The prize honours a scientist who has distinguished themselves in the field of research that has directly or indirectly led to the development of new medicines…