Ferritin is a spherical metalloprotein, capable of storing and releasing iron in a controllable way. It is composed of a protein shell of about 12 nm and within its cavity, iron is stored in a mineral form.

Multicopper oxidase, laccase, can efficiently reduce oxygen to water and are mostly used in the enzymatic biofuel cells.

Promotor: Prof.dr. M. Ubbink

This thesis explores how electron paramagnetic resonance (EPR) spectroscopy can be used to investigate key biochemical processes.

Promotor: T.H. Oosterkamp

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

The aim of the research presented in this thesis was to develop new methods forchallenging systems in liquid-state NMR using paramagnetic effects generated by thetwo-armed probe CLaNP-5.

Promotor: Prof.dr. M. Ubbink

Promotor: Prof.dr. M. Ubbink

Hass

Alzheimer's disease (AD) is the most frequent neurodegenerative disorder and the primary cause of dementia. The neuropathological features of AD include the occurrence of senile plaques, neurofibrillary tangles, decreased synaptic density, and loss of neurons. An obstacle in the study and treatment…

In this thesis, we describe the latest advances in SQUID-detected Magnetic Resonance Force Microscopy (MRFM).

In this thesis, we show how MRFM can usefully contribute to the field of condensed-matter.

Promotor: Prof.dr. E.J.J. Groenen

The thesis describes the use of electron paramagnetic resonance (EPR) spectroscopy, in continuous wave and pulse modes, to address the interaction of α-Synuclein (αS) with membranes and the aggregation of αS.

Protein–protein complexes are formed via transient states called encounter complexes that greatly influence the formation of the stereospecific complex.

Over time Dutch and Indonesian composers, performers and music scholars have inspired each other and they continue to do so. The presence of the Dutch in the Netherlands East-Indies and Indonesia, but also the existence of large diasporic communities in the Netherlands have contributed to a mutual exchange…

A small number of EC points from your elective space can be obtained through project work instead of taking elective courses. This enables students to work on a project that they really want to do.

Elective courses enable students to gain deeper insight into scientific topics of their choice, and they prepare students for their individual graduation project. They can be elected from Leiden University, but also from other (inter)national universities.

Electives offer students the opportunity to further specialise and deepen in specific aspects of leadership.

The primary goal of this research is to deepen our understanding of substrate-enzyme interactions in Glycoside hydrolases. For this purpose, Bacillus circulans xylanase (BcX) has been selected as a well-established model to examine the Michaelis complex and glycosyl-enzyme adduct.

Leiden University values participation: the participation organs are the ears and eyes of the university. They identify issues of concern among staff and students and help advise and decide on the future of our organisation. Something for you? Then stand as a candidate! This year, elections will…

SMR can be used to measure the mass of adsorbed protein to nanoparticles with a high precision in the presence of free protein.

Nuclear Magnetic Resonance (NMR) Spectroscopy is a non-destructive analytical technique that is used to study the nature and characteristics of molecules with an atomic level precision. It has a wide range of applications especially in synthetic chemistry, biological and biochemical research groups…

Does your programme have an elective space of only 15EC? Then you can follow a modified programme of the American Studies minor, which we call 'Elective credits'.

Zebrafish is an excellent model organism for studying various human diseases. Due to opaqueness of the adult phase, in vivo studies are restricted to early embryonic stages. This raises the need for rapid sensitive and non-invasive in vivo imaging methods to follow developmental processes, not only…

Promotor: H.J.M. de Groot, Co-Promotor: A. Alia

As a student or staff member, you can stand as a candidate for two participatory bodies: the Faculty Council of Humanities and the University Council. In both cases, you represent the interests of students and staff members and contribute ideas to policy. Are you considering standing as a candidate…

With the University Council elections approaching, the Leiden University Green Office (LUGO), with the support of LU's Central Sustainability Team and the D&I Office, contacted all seven candidate parties to inform our community about their views on sustainability and diversity. We asked each party…

LUCDH offers 5 faculty-wide elective courses to improve your practical skills and thinking about digital tools and media. These courses are open and useful for all students of the Humanities.

LUCDH offers five elective courses to improve your practical skills and thinking about digital tools and media. These courses are open and useful for all students of the Humanities.

Research groups in the Biological & Soft Matter Programme unravel mechanisms in biological processes and develop novel bio-inspired soft materials.

In this article, Madeleine Hosli, Professor of International Relations at the Institute of Security and Global Affairs, and Jaroslaw Kantorowicz, Assistant Professor at the Institute of Security and Global affairs, discusses the relevance of structural variables in a time where European politics are…

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

This thesis consists of two subjects, that are both a consequence of radiation pressure.

Multi-channel sound and video installation of the on-going project: Decomposing Landscape (2014 -).

Prior to the 2020 presidential election, historians considered the disputed 1876 contest—which pitted Republican Rutherford B. Hayes against Democrat Samuel J. Tilden—the most controversial in American history.

Political scientist Tom Louwerse (Leiden University), analysing several recent opinion polls, expects that after the March 2017 elections in the Netherlands, a relatively large number of mid-sized parties will gain representation in the Dutch parliament. If the predictions are anything close to the…

This research cluster is a part of the Institute of Political Science’s research programme ‘Institutions, Decisions and Collective Behaviour’.

The parliamentary elections in the Netherlands, scheduled for March 2017, are likely to result in a fragmented parliament and a complicated coalition formation process, according to Dutch political scientist Hans Vollaard (Leiden University).

Dynamic nuclear polarization with paramagnetic agents can enhance nuclear magnetic resonance signals by orders of magnitude. The mechanism of enhancement depends a.o. on the magnetic resonance properties of the agents used. Electron spin relaxation times at NMR relevant magnetic field/microwave frequencies,…

China is a one-party regime, yet elections are held for the local congresses. PhD candidate Wang Zhongyuan investigated how the Communist Party uses this democratic instrument to strengthen the authoritarian regime. PhD defence 31 January.

In this article, Honorata Mazepus, assistant professor at the Institute of Security and Global Affairs, and Dimiter Toshkov, associate professor at the Institute of Public Administration, discuss whether the winner–loser gap extends beyond the political domain to subjective health and well-being as…

Master projects are available in

Today is the general election in the Netherlands – although the polling stations have actually been open for two days already because of the coronavirus restrictions. Leiden researchers and students are involved in all manner of ways, and are analysing the campaigns and possible results.

Special amplifying agents can make MRI scanners and NMR techniques hundreds of times more sensitive. Leiden physicists have now found a method to test their efficiency. More sensitive MRI scans could for example improve our understanding of cystic fibrosis or Parkinson’s disease. Publication in PCCP…

This book is an examination of why and how the elective principle, already established in Transylvanian and Polish political culture in the late medieval period, was transformed in the early elections of the 1570s.

A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.