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On 17 November 2021, Cyril-Igor Grigorieff defended the thesis 'The Regime for International Air Carrier Liability'. The doctoral research was supervised by Prof. P. Mendes de Leon and Prof. V. Correia (University Paris Saclay).

Utilizing the polymeric platform of polypept(o)ides, this thesis describes synthesis and investigation of novel triblock copolymers to obtain carrier systems with multiple compartments for efficient siRNA delivery. Although the individual microstructure of nanoparticles differs depending on the polymeric…

Is aggression always bad? PhD research by psychologist Simone Dobbelaar shows that it is not. In fact, children who occasionally fiercely defend themselves and stand up for their peers often feel better mentally.

NNMT wordt beschouwd als een nieuw potentieel farmacologisch doelwit in de behandeling van een verscheidenheid van kankers, stofwisselingsziekten en andere pathologieën. Het toenemend aantal publicaties waarin de rol van NNMT bij ziekten wordt opgehelderd, heeft op zijn beurt de ontwikkeling van krachtige…

This thesis revolves around the electronic spectroscopy of molecules in the laboratory and the search for the carriers of the diffuse interstellar bands (DIBs).

Promotor: Prof.dr. P. Hooykaas, Co-promotor: Dr. R. Offringa

Ontwikkeling van resistentie tegen antibiotica kan optreden als patiënten onnodig of te lang met antibiotica behandeld worden. Diagnostiek waarmee snel een bacteriële infectie vastgesteld kan worden, of de response op antibiotica bepaald kan worden, zijn daarom belangrijk om therapie te optimaliseren…

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

Beenakker

Can light-activatable ruthenium compounds be used as a more selective anticancer treatment?

The plant hormone auxin regulates plant growth and development through polar cell-to-cell transport-generated maxima and minima. PIN FORMED (PIN) auxin efflux carriers determine the direction of this auxin flow through their asymmetric placement on the plasma membrane (PM).

The elementary excitations of magnets are called spin waves, and their corresponding quasi-particles are known as magnons. The rapidly growing field of Magnonics aims at using them as information carriers in a new generation of electronic devices, (almost) free of electric currents.

Members of our research team give different types of presentations and lectures.

Een onderzoek naar de formulering, structuur, rechtshistorische aard en sociale en religieuze achtergronden van Laat-Egyptische (demotische) tempeleden, aangevuld met 70 ongepubliceerde teksten.

In the search for sustainable energy solutions, the idea of artificial photosynthesis has been proposed as an approach with which to use water and sunlight to produce hydrogen.

The Leiden Leadership Centre conducts research into the development of effective public leadership within and between organisations. On the basis of our research and development agenda ‘Furthering Public Leadership’, we focus on public leadership in a public context, on its societal impact, and on leadership…

Promotor: G.A. van der Marel, Co-Promotor: J.D.C. Codée

Marietje Beemsterboer defended her thesis on 12 June 2018 (in Dutch)

The central theme of Rik Mom’s research group is to identify what the electrode-electrolyte interface looks like when electrocatalysis is taking place. Using specialized forms of Raman and X-ray spectroscopy, we study the chemical state and bonding environment of the electrode surface and near-surface…

Examining if large scale application of new energy pathways can be constrained by materials and emissions.

In this thesis we use Josephson and noise scanning tunneling microscopy for the study of conventional, unconventional (iron-based) and disordered superconductors. On the one hand, Josephson scanning tunneling microscopy allows us to directly visualize the superfluid density with high spatial resolut…

A research project by Developmental Psychology professor Carolien Rieffe and researchers of the Leiden Institute of Advanced Computer Science has been voted Smartest Project of the Netherlands 2016.

Lecture

HZ Kenniscentrum Zeeuwse Samenleving doet op vraag van regionale overheden en maatschappelijke organisaties onderzoek naar actuele en maatschappelijke thema’s in de provincie Zeeland. De uitkomsten van onderzoeken en analyses worden gebruikt voor kennisopbouw en als basis voor beleidsopbouw en -ontwikkeling.…

Een nieuw boek in de reeks Elementaire deeltjes

Mathematical and computational analysis of the dynamics of polar transport of the plant hormone auxin.

Lecture, Journalism Studies Seminars

1. What is the exact role of PIN proteins in PAT? 2. How is PIN polarity established, and how is it modulated by AGC kinase-mediated phosphorylation? 3. What is the role of the AGC kinase, as modulators of PAT, in translating environmental signals, such as gravity, light or mechanical stress, to plant…

On 16 December 2021, Lisanne van Houten defended the thesis 'Flexing the Slot Regime'. The doctoral research was supervised by Prof. P. Mendes de Leon and Prof. L. Pierallini (Luiss University Of Rome).

The main focus of this thesis is the behaviour of two-dimensional materials, namely (anti)-ferromagnetic materials in the first two chapters, which show topological phases, and energetic square ice in the third and fourth chapter.

Currently, several successful vaccines are available. However, for pathogens with a highly variable genetic composition, and for which serum IgG antibodies are not a useful correlate of protection, effective vaccines are yet to be developed.

Control of infectious diseases poses continuous challenges for human health.

This thesis describes the design, characterization and application of dextran based crosslinked network.

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

Polycyclic aromatic hydrocarbons (PAHs) are the most abundant class of organic compounds in space. The PAH field evolves from the constant interaction between experimentalists, theorists, modellers and observers. While laboratory research and quantum chemical calculations together set up the molecular…

Social and Behavioural Sciences, LUBEC

In welke mate hebben domaniale structuren de machtsvorming en nederzettingsontwikkeling in en van het gewest Holland bepaald?

With the rise of information and communication technologies, large amounts of data are being generated and stored in databases. In order to get a better grip on these large amounts of data, serious efforts are being made to discover patterns and relations in the data with the help of new techniques.…

The SAPPAO project aims to optimise the accuracy and reliability of predicting scheduled flight times. The full name of the project is 'A Systems Approach towards Data Mining and Prediction in Airlines Operations'.

This thesis presents the results of a study on the interfaces of insulating oxides with and without the insertion of a magnetic layer.

The loss of T-cell homeostasis and tolerance towards self-antigens is the underlying cause of autoimmune and inflammatory diseases like atherosclerosis, rheumatoid arthritis or type I diabetes. Traditionally, the treatment of these diseases consisted on systemic immune suppression, which can entail…

The plant hormone auxin plays a central role in the growth and development of plants. Auxin acts in a concentration dependent manner and polar cell-to-cell transport of this hormone determines its distribution in the tissues of plants. This polar auxin transport is mediated by several families of auxin…

Promotor: E. Bouwman, Co-promotor: S. Bonnet

With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.

Science, Leiden Institute of Physics (LION), Leiden Observatory

The chemical industry must continue to innovate for a more sustainable, healthier society. The reseachers from the Leiden Institute of Chemistry (LIC) contribute by applying their knowledge to themes such as sustainability, energy and health.

The polypept(o)ide hybrid material attracted more and more attention over the past decade by combining the multifunctional characteristics of polypeptides with the shielding characteristics of polypeptoid-pSar possessing similar properties as a shielding material as polvethylene glycol(PEG). Polysarcosine…

The Delivery of Biotherapeutics research group is led by Prof. Matthias Barz and focusses on the synthesis and characterization of polypept(o)ids and their application in nanomedicine to improve existing therapies or enable novel diagnostic or therapeutic approaches.