1,321 search results for “ancient dna” in the Public website
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ERC grant for Sebastian Pomplun to precisely influence gene expression
In order to stop a whole range of diseases or disorders at their source, you would have to be able to switch certain genes on or off. Sebastian Pomplun wants to develop substances that can do this very precisely. For example, he wants to disrupt cancer processes and make cells produce an important missing…
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DNA-Decorated soft nanostructures from the self-assembly of DNA amphiphiles
Lecture
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NWO ECHO grant for research on fickle RNA production
Genes are active sometimes, and other times they remain dormant for a while. Leiden physicist John van Noort receives an NWO ECHO grant to find out how this happens.
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Unspinning chromatin: molecular mechanisms of chromatin remodeling
How do you fit two meters of DNA in a tiny compartment and at the same time are able to access the right parts of it at the right times?
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Measuring water life
Human activity, such as pollution, may disturb the balance of living water systems, which has consequences for biodiversity, but also for other functions such as water purification. Leiden University maps living water systems using the most advanced technologies.
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Functional analysis of agrobacterium tumefaciens virulence protein VirD5
Supervisor: P.J.J. Hooykaas
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A Descriptive grammar of Sumerian
This grammar describes Sumerian, an ancient Near Eastern language which was spoken in what is now southern Iraq, on the basis of written sources dating from about 2500 to 2000 BC.
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John van Noort Lab - Chromatin Dynamics
Chromatin is an ubiquitous protein-DNA complex that forms the structural basis of DNA condensation in all eukaryotic organisms.
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Layers of dental tartar
Bacteria in the teeth tell us a lot about nutrition and disease in our ancestors. It also tells us more about the immune system. This provides clues for treating modern diseases and allergies. For a long time archaeologists were irritated by tartar on the teeth of excavated skulls. They thought that…
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Shaping proteins to understand chaperone-related diseases
Alireza Mashaghi and his research team have created a new framework to understand shapes of proteins and DNA. With this framework, many diseases can be understood better.
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Chromatin organisation & dynamics
The genomic DNA of every organism is organized and compacted in order to fit inside the cell. This is achieved by the joint action of numerous architectural proteins that aid in folding the genome. Genome folding is tightly interconnected with transcription, with genes in certain regions being silenced,…
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The writing on the rocks: Thamidic and Arabia's linguistic past
This project aims to open up the pre-Islamic linguistic history of Arabia through the systematic study of the Thamudic inscriptions within a digital humanities framework.
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Thy Name is Deer. Animal Names in Semitic Onomastics and Name- Giving Traditions: Evidence from Akkadian, Northwest Semitic, and Arabic
Hekmat Dirbas defended his thesis on 14 February 2017
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Mechanisms and consequences of horizontal gene transfer in cell wall-deficient cells of Kitasatospora viridifaciens
The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…
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Urbanism and municipal administration in Roman North Africa
This project uses archaeological, literary and epigraphic evidence to investigate urban development in Roman-period North Africa, compiling this in a GIS-linked database in order to analyse the development of urban settlement spatially over time.
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Greater focus on pre-Islamic heritage
War and terrorism overshadow interest in the pre-Islamic heritage of the Arabic peninsula. The new Leiden Centre for the Study of Ancient Arabia aims to make the general public more aware of the ancient history of this region.
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New open access, peer-reviewed journal: Arabian Epigraphic Notes
The Leiden Center for the Study of Ancient Arabia (LeiCenSAA) announces a new open access, peer-reviewed journal dedicated to the epigraphy of Arabia and its cultural and linguistic context: Arabian Epigraphic Notes
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The reconstruction of the codex Añute palimpsest using hyperspectral imaging data
A technique originally developed for satellite imaging can now be used to recover pictographic texts from underneath the surface of a five hundred year old Mexican manuscript.
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Participants
The CIGR comprises research groups from the Institute of Biology Leiden (IBL), the Leiden Institute of Chemistry (LIC), the Leiden Academic Centre for Drug Research (LACDR) and the Leiden Institue of Physics (LION).
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Cancer and heredity
Some people are predisposed to develop cancer. Mutations in genetic material that increase a person’s chances of developing cancer can already be present at birth. Researchers are closely examining these mutations to learn more about how cancer begins to develop.
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Molecular engineering of plant development using Agrobacterium-mediated protein translocation
Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa
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New generation of graphene biosensors based on smooth surfaces and sharp edges
The surface and the edges of graphene are expected to provide higher sensitivity and specificity in detecting and characterizing single molecules. However fundamental physical limits exist in reaching an ultimate precision in detecting the dynamics of chemical and biological systems. The research in…
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Urban Craftsmen and Traders in the Roman World
This volume, featuring sixteen contributions from leading Roman historians and archaeologists, sheds new light on approaches to the economic history of urban craftsmen and traders in the Roman world, with a particular emphasis on the imperial period.
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The Archaeology of Greater Nicoya
Two Decades of Research in Nicaragua and Costa Rica
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The Long Arab Conquest of Central Asia: Urban Change in Merv, Paikent, Balkh and Samarkand (651-821)
This PhD research aims to trace the impact of the Arab conquest, both immediate and long-term, on the material and social organization of Central Asia from 651 to 821 through an “urban change” perspective in four cities: Merv, Paikent, Balkh and Samarkand.
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Re-assessing the environmental impact of early Roman expansion
This project aims to explore the environmental impact of early Roman expansion (4th/3rd century BC) through a program of dating and ecological sampling of traces of field systems (centuriations).
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The development of the Proto-Indo-European syllabic liquids in Greek
Ancient Greek was spoken in a large number of different dialects. Although we do not find direct evidence for syllabic liquids in any of our sources, comparative evidence shows that these sounds must have been present in Proto-Greek, and that they were retained until comparatively recently in the prehistory…
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Introducing: Pieter Houten
Pieter Houten is a PhD student in the ERC granted research project 'An Empire of 2000 Cities: urban networks and economic integration in the Roman empire', directed by Luuk De Ligt and John Bintliff (Archaeology).
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First patient in the Netherlands successfully treated with stem cell gene therapy
Researchers from the Leiden University Medical Center (LUMC) have successfully used stem cell gene therapy to treat a baby with the severe congenital immune disorder SCID. An important milestone: it is the first time stem cell gene therapy of Dutch origin has been administered to a patient, and also…
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Key publications
Key research articles and book chapters of the Chromatin group.
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High fidelity DNA replication and repair
PhD defence
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Efficient targeting of the Trichoderma genome for industrial protein engineering
The research is aimed at development of an efficient gene targeting method that allows controlled integration of DNA at a preselected site in the Trichoderma genome.
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Alessandro Aleo
Faculteit Archeologie
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Yuye Que
Faculty of Humanities
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Luuk de Ligt
Faculty of Humanities
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Nico Staring
Faculty of Humanities
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Ruurd Halbertsma
Faculty of Humanities
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Valentina Azzarà
Faculteit Archeologie
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Gerard Versluis
Faculteit Rechtsgeleerdheid
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Annelou van Gijn
Faculteit Archeologie
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Michael Kerschner
Faculteit Archeologie
- Laboratory for Ceramics Studies
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Fighting tumours with light
Chemotherapy that does nothing until you irradiate it with light. Sylvestre Bonnet receives a Vici grant of 1.5 million euros for the development of this treatment. The Leiden chemist wants to build a new molecule to fight tumours that are at the time still difficult to treat.
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The researchers
Professor of Ecotoxicology Martina Vijver and lecturer Maarten Schrama are the founders and managers of the Living Lab. As well as these two researchers, a number of other ecologists and biologists are involved in the research at the Lab.
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Quantifying nucleosome dynamicsand protein binding with PIE-FCCS and spFRET
In this thesis I describe the results of Pulsed Interleaved Excitation and Fluorescence (Cross) Correlation Spectroscopy (PIE-F(C)CS) combined with single-pair Förster Resonance Energy Transfer (spFRET) used to study dynamics in single nucleosomes, which depends on subtle differences in the length of…
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Our approach
Our group operates at the cross-roads of different disciplines: molecular and cellular microbiology, biochemistry, structural biology and biophysics. The group harbors expertise in a multitude of molecular and cellular approaches including:
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Responding to environmental cues: the adaptive qualities of chromatin compaction proteins
Promotor: M. Ubbink, Co-Promotor: R. T. Dame
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Helmut Schiessel Group - Theoretical Physics of Life Processes
The group Theoretical Physics of Life Processes, led by Helmut Schiessel, focuses on the physics of chromatin, the DNA-protein complex that fills the nuclei of eukaryotic cells.
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Self-assembly of Colloidal Particles
The miniaturization of machines towards the micron and nanoscale requires the development of joint-like elements that enable and constrain motion. We developed a facile method to create colloidal joints, that is, anisotropic colloidal particles functionalized with surface mobile DNA linkers that control…
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Centre for Microbial Cell Biology
The CMCB brings together microbial cell biology expertise in Leiden. It aims at optimal resonance between the groups and maximal exploitation of the available infrastructure and to develop innovative cross-boundary technology platforms.