How do mycobacteria subvert the defenses of host immune cells?

What are the host immune defence mechanisms that control intracellular infections and how are these subverted by pathogens?

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

Promotores: A.H. Meijer, H.P. Spaink

Antimicrobial resistance is one of the biggest threats to human health worldwide in the coming decennia.

This thesis investigates innovative and classical strategies in glycoconjugate vaccine development to address the growing threat of multidrug-resistant bacterial infections.

Bacteria whirl around in the mouths of most people, forming dental plaques and sometimes causing nasty gum infections. Treponema denticola might be a dangerous pathogen, but not much is known about this bacterium. It was up to Ariane Briegel and her research group to change that.

The challenge is considerable, but so is the satisfaction when it succeeds: creating complex sugar molecules that play a role in biology.

Exploiting the Ecological Role of Natural Products as Novel Biocontrol Agents (LIPQUORUM): The central aim of LIPQUORUM is to unravel the intricate interkingdom signaling mechanisms between the Bacillus subtilis species complex and the devastating fungal pathogen Sporisorium scitamineum.

How are the epidermal lipid pathways involved in health and disease.

Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…

The bacterium Vibrio cholerae is a serious threat to our health because it is the causative agent of cholera. Worldwide, over a billion people per year are at risk of cholera infection. New strains of V. cholerae are resistant to the multiple drugs used to treat cholera, meaning that new types of drugs…

The Laboratory for Human Osteoarchaeoloy examines human remains and their burial context to address questions about the human past.

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: Dr. A. El Ghalbzouri

Vancomycin is a last-resort antibiotic for the treatment of many Gram-positive bacterial infections, while remaining inactive against Gram-negative strains.

Hermeneutics and the Humanities: Dialogues with Hans-Georg Gadamer / Hermeneutik und die Geisteswissenschaften: Im Dialog mit Hans-Georg Gadamer

Despite substantial progress in understanding tuberculosis (TB), the eradication of the TB epidemic is still far from reach.

Despite the field’s general agreement that pyrotechnology had a significant impact on the cultural evolution of humankind, our understanding of the origins and development of fire use and its role in humankind’s cultural evolution is very limited, blurred by strong disagreements over its chronology…

Melanie Fink, Postdoctoral Researcher at the Europa Institute of Leiden University, has published her book Frontex and Human Rights, Responsibility in 'Multi-Actor Situations' under the ECHR and EU Public Liability Law. This work is based on her doctoral dissertation, which she defended in December…

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…

Fungi germinating in the lungs of patients. Doesn’t sound too nice, does it? Luckily, humans can deal with this normally, and we are able to clear the infection before anything comes to harm. However, in people with health issues, Aspergillosis can cause a lot of damage, especially if the fungus becomes…

The currently available in vitro generated human skin equivalents resemble the human skin in many aspects. However, some essential barrier characteristics do not fully mimic the native barrier. Consequently, the human skin equivalents cannot be used for screening of drugs for skin penetration.

This article discusses the degree of independence that is required for national human rights institutions to function successfully.

On 1 October 2019 the Hazelhoff Centre for Financial law hosted its 19th guest lecture starring Paul Sharma, managing director at Alvarez & Marsal and co-head of the European Financial Industry Regulatory Advisory Services practices.

Leiden’s Faculty of Humanities is one of the broadest of its kind, offering courses in no fewer than 80 different languages and a very broad spectrum of academic disciplines.

The Faculty of Humanities

The Faculty of Humanities has 8 institutes:

In the Humans of Humanities series, we will do a portrait of one of our researchers, staff members or students, every other week.

As a Faculty of Humanities graduate you are part of a valuable network. Discover how you can remain in contact with other alumni and the University!

This thesis examines strategies to address the global threat of antimicrobial resistance (AMR). Antimicrobial resistance poses an increasing global health risk, highlighting the need for new treatments against Gram-negative pathogens.

Tackling human trafficking has been a priority on international, national and local policy agendas for some decades now. Yet a number of knowledge gaps stand in the way of how the issue is approached. Interdisciplinary research is essential if we want to expand our knowledge to benefit policy and pr…

The HARVEST project explores the dietary choices that our hominin ancestors and relatives made, by recovering information on what they consumed, and how factors like environmental variation, intrinsic biology, and development of food processing technologies could have influenced their decisions.

Environmental Humanities is one of the LUCAS research themes, bringing together members of the three LUCAS clusters.

The Human Origins group at Leiden University studies the archaeology of hunter-gatherers, from the earliest stone tools in East Africa, more than three million years old, to the origin of sedentary societies towards the end of the last ice age.

Humanities Campus Project is the name of the redevelopment of the Witte Singel-Doelen Complex, the location of the Faculty of Humanities and associated knowledge partners and institutes. Over a period of ten years the complex will undergo a gradual metamorphosis, while classes continue to be taught.…

At the Humanities Hub, researchers can immerse themselves in the world of Digital Humanities, while students get the opportunity to develop their digital and media skills within the field of the humanities. The lab spaces of LUCDH, the Faculty of Humanities, and Journalism and New Media provide modern…

This multidisciplinary minor addresses the fascinating question how we, modern humans, got to be the way we are. Who were our ancestors? How does our morphology, genetic makeup, brain and behaviour relate to that of other species? How does our evolutionary past affect our susceptibility to diseases?…

Leiden University is building on its future in Leiden. As a means to achieving this aim, the University will be investing in excess of 100 million euros over the coming years in constructing the new accommodation for the Faculty of Humanities at Witte Singel and Doelensteeg. The University aims with…

There is considerable need for improved skin models to develop safe and efficient drugs for skin delivery as well as for cosmetic and chemical product testing on the skin.

Human AI is where artificial intelligence and machine learning meet philosophy, cognitive science, and the creative arts. Examples of research questions in this domain are: 'Can an algorithm be creative by human standards?', 'Can creative processes, such as composing music or writing poetry, be modelled?',…

What are the patterns and processes of human mobility in the pre-colonial circum-Caribbean as revealed by burial populations and what are the underlying motives and socio-cultural principles on both micro- and macro-scales?

To what extent are, can, and should, human trafficking and human smuggling be(ing) seen as interlinked phenomena? What are the consequences of seeing the phenomena as either distinct or interlinked for the way in which migrants crossing intra-Schengen borders are treated.

This project studies the roles of prehistoric foragers in past ecosystems to establish the character of past “natural” landscapes and enhance the management of current ones.

AI has huge societal and economic potential and is widely used. But it also brings challenges: how do we combine human values with AI, how do we make AI more transparent and understandable, and what can AI and human cognition learn from each other, for example about language learning?

Study of human cultures using computational approaches

Beneficial plant-associated microbiota, particularly those inhabiting the rhizosphere, contribute substantially to plant health through pathogen suppression, stimulation of plant defence responses, and enhanced nutrient acquisition.